Tolerogenic dendritic cells modified by tacrolimus suppress CD4+ T-cell proliferation and inhibit collagen-induced arthritis in mice

Tolerogenic dendritic cells (tDCs) can be generated in vitro by a variety of methods, including genetic or pharmacological modification. DCs that were modified by the immunosuppressive drug tacrolimus were considered to be endowed with tolerogenic functions. DCs derived from human monocytes were ind...

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Veröffentlicht in:	International immunopharmacology 2014-07, Vol.21 (1), p.247-254
Hauptverfasser:	Ren, Yana, Yang, Yiming, Yang, Jie, Xie, Rufeng, Fan, Huahua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Experimental - immunology Arthritis, Experimental - therapy CD4-Positive T-Lymphocytes - immunology Cell Differentiation - drug effects Cell Proliferation Cell therapy Cells, Cultured Collagen-induced arthritis Cytokines - genetics Cytokines - metabolism Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - transplantation Disease Progression Gene Expression Regulation - drug effects Humans Immune Tolerance Immunosuppression Immunotherapy - methods Male Mice Mice, Inbred DBA Tacrolimus Tacrolimus - pharmacology Tolerogenic dendritic cells Tolerogenic function
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