Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study
The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Austra...
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| Veröffentlicht in: | Journal of Crohn's and colitis 2014-07, Vol.8 (7), p.598-606 |
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| creator | Gibson, Peter R. Vaizey, Carolynne Black, Christopher M. Nicholls, Rebecca Weston, Adèle R. Bampton, Peter Sparrow, Miles Lawrance, Ian C. Selby, Warwick S. Andrews, Jane M. Walsh, Alissa J. Hetzel, David J. Macrae, Finlay A. Moore, Gregory T. Weltman, Martin D. Leong, Rupert W. Fan, Tao |
| description | The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population.
A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life–8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires.
In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps |
| doi_str_mv | 10.1016/j.crohns.2013.11.017 |
| format | Article |
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A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life–8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires.
In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps<0.001). IBDQ correlated with both AQoL-8D (r=0.73; P<0.0001) and EQ-5D-5L (0.69; P<0.0001). Mean 3-month UC-related health care cost per patient was AUD $2914 (SD=$3447 [mean for patients in remission=$1970; mild disease=$3736; moderate/severe disease=$4162]). Patients in remission had the least work and activity impairment.
More severe UC disease was associated with poorer QoL. Substantial health care utilization, costs, and work productivity impairments were found in this sample of patients with UC. Moreover, greater disease activity was associated with greater health care costs and impairment in work productivity and daily activities.</description><identifier>ISSN: 1873-9946</identifier><identifier>EISSN: 1876-4479</identifier><identifier>DOI: 10.1016/j.crohns.2013.11.017</identifier><identifier>PMID: 24345767</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Australia ; Colitis, Ulcerative - economics ; Colitis, Ulcerative - therapy ; Cross-Sectional Studies ; Disease severity ; Drug Costs ; Efficiency ; Female ; Health Care Costs ; Health care utilization ; Health Services - economics ; Health Services - utilization ; Hospitalization - economics ; Humans ; Male ; Middle Aged ; Quality of Life ; Retrospective Studies ; Severity of Illness Index ; Surveys and Questionnaires ; Ulcerative colitis ; Utility ; Work Capacity Evaluation ; Young Adult</subject><ispartof>Journal of Crohn's and colitis, 2014-07, Vol.8 (7), p.598-606</ispartof><rights>2013 European Crohn's and Colitis Organisation</rights><rights>Copyright © 2013 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-5d6128cffdcc8097a589c1a7f12dd1130a4f17bf800d5e47c87062ce08e028e63</citedby><cites>FETCH-LOGICAL-c428t-5d6128cffdcc8097a589c1a7f12dd1130a4f17bf800d5e47c87062ce08e028e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24345767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gibson, Peter R.</creatorcontrib><creatorcontrib>Vaizey, Carolynne</creatorcontrib><creatorcontrib>Black, Christopher M.</creatorcontrib><creatorcontrib>Nicholls, Rebecca</creatorcontrib><creatorcontrib>Weston, Adèle R.</creatorcontrib><creatorcontrib>Bampton, Peter</creatorcontrib><creatorcontrib>Sparrow, Miles</creatorcontrib><creatorcontrib>Lawrance, Ian C.</creatorcontrib><creatorcontrib>Selby, Warwick S.</creatorcontrib><creatorcontrib>Andrews, Jane M.</creatorcontrib><creatorcontrib>Walsh, Alissa J.</creatorcontrib><creatorcontrib>Hetzel, David J.</creatorcontrib><creatorcontrib>Macrae, Finlay A.</creatorcontrib><creatorcontrib>Moore, Gregory T.</creatorcontrib><creatorcontrib>Weltman, Martin D.</creatorcontrib><creatorcontrib>Leong, Rupert W.</creatorcontrib><creatorcontrib>Fan, Tao</creatorcontrib><title>Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study</title><title>Journal of Crohn's and colitis</title><addtitle>J Crohns Colitis</addtitle><description>The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population.
A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life–8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires.
In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps<0.001). IBDQ correlated with both AQoL-8D (r=0.73; P<0.0001) and EQ-5D-5L (0.69; P<0.0001). Mean 3-month UC-related health care cost per patient was AUD $2914 (SD=$3447 [mean for patients in remission=$1970; mild disease=$3736; moderate/severe disease=$4162]). Patients in remission had the least work and activity impairment.
More severe UC disease was associated with poorer QoL. Substantial health care utilization, costs, and work productivity impairments were found in this sample of patients with UC. Moreover, greater disease activity was associated with greater health care costs and impairment in work productivity and daily activities.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Australia</subject><subject>Colitis, Ulcerative - economics</subject><subject>Colitis, Ulcerative - therapy</subject><subject>Cross-Sectional Studies</subject><subject>Disease severity</subject><subject>Drug Costs</subject><subject>Efficiency</subject><subject>Female</subject><subject>Health Care Costs</subject><subject>Health care utilization</subject><subject>Health Services - economics</subject><subject>Health Services - utilization</subject><subject>Hospitalization - economics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Quality of Life</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Surveys and Questionnaires</subject><subject>Ulcerative colitis</subject><subject>Utility</subject><subject>Work Capacity Evaluation</subject><subject>Young Adult</subject><issn>1873-9946</issn><issn>1876-4479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcGO0zAQjRCIXQp_gJCPHEiwEyd2OCBVK1iQVkJCcLZce6y6cpOuxykqX8bn4SS7HDnNzNN7bzx-RfGa0YpR1r0_VCaO-wGrmrKmYqyiTDwprpkUXcm56J8ufVP2Pe-uiheIB0rbvhXyeXFV84a3ohPXxZ_vEHTy44B7fyI7SL8ABmI9gkYgCGeIPl2IHiy5n3SY-9GR4B0smEYExCMMaYb3oEPaE6MjkCn54H8v1gvTjJiIGyOZgoGY8TNkLBt6JH4g2wlTzP76A9mSfBhiiWBmtQ7vyLhDiGe9jgTTZC8vi2dOB4RXD3VT_Pz86cfNl_Lu2-3Xm-1daXgtU9najtXSOGeNkbQXupW9YVo4VlvLWEM1d0zsnKTUtsCFkYJ2tQEqgdYSumZTvF19T3G8nwCTOno0EIIeYJxQsbZhfcvnEDYFX6nL-yM4dYr-qONFMarmzNRBrZmpma4YUzmzLHvzsGHaHcH-Ez2GlAkfVwLkO88eokLjYTBgfcx_pOzo_7_hL0Hkrzk</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Gibson, Peter R.</creator><creator>Vaizey, Carolynne</creator><creator>Black, Christopher M.</creator><creator>Nicholls, Rebecca</creator><creator>Weston, Adèle R.</creator><creator>Bampton, Peter</creator><creator>Sparrow, Miles</creator><creator>Lawrance, Ian C.</creator><creator>Selby, Warwick S.</creator><creator>Andrews, Jane M.</creator><creator>Walsh, Alissa J.</creator><creator>Hetzel, David J.</creator><creator>Macrae, Finlay A.</creator><creator>Moore, Gregory T.</creator><creator>Weltman, Martin D.</creator><creator>Leong, Rupert W.</creator><creator>Fan, Tao</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study</title><author>Gibson, Peter R. ; Vaizey, Carolynne ; Black, Christopher M. ; Nicholls, Rebecca ; Weston, Adèle R. ; Bampton, Peter ; Sparrow, Miles ; Lawrance, Ian C. ; Selby, Warwick S. ; Andrews, Jane M. ; Walsh, Alissa J. ; Hetzel, David J. ; Macrae, Finlay A. ; Moore, Gregory T. ; Weltman, Martin D. ; Leong, Rupert W. ; Fan, Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-5d6128cffdcc8097a589c1a7f12dd1130a4f17bf800d5e47c87062ce08e028e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Australia</topic><topic>Colitis, Ulcerative - economics</topic><topic>Colitis, Ulcerative - therapy</topic><topic>Cross-Sectional Studies</topic><topic>Disease severity</topic><topic>Drug Costs</topic><topic>Efficiency</topic><topic>Female</topic><topic>Health Care Costs</topic><topic>Health care utilization</topic><topic>Health Services - economics</topic><topic>Health Services - utilization</topic><topic>Hospitalization - economics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Quality of Life</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Surveys and Questionnaires</topic><topic>Ulcerative colitis</topic><topic>Utility</topic><topic>Work Capacity Evaluation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gibson, Peter R.</creatorcontrib><creatorcontrib>Vaizey, Carolynne</creatorcontrib><creatorcontrib>Black, Christopher M.</creatorcontrib><creatorcontrib>Nicholls, Rebecca</creatorcontrib><creatorcontrib>Weston, Adèle R.</creatorcontrib><creatorcontrib>Bampton, Peter</creatorcontrib><creatorcontrib>Sparrow, Miles</creatorcontrib><creatorcontrib>Lawrance, Ian C.</creatorcontrib><creatorcontrib>Selby, Warwick S.</creatorcontrib><creatorcontrib>Andrews, Jane M.</creatorcontrib><creatorcontrib>Walsh, Alissa J.</creatorcontrib><creatorcontrib>Hetzel, David J.</creatorcontrib><creatorcontrib>Macrae, Finlay A.</creatorcontrib><creatorcontrib>Moore, Gregory T.</creatorcontrib><creatorcontrib>Weltman, Martin D.</creatorcontrib><creatorcontrib>Leong, Rupert W.</creatorcontrib><creatorcontrib>Fan, Tao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Crohn's and colitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gibson, Peter R.</au><au>Vaizey, Carolynne</au><au>Black, Christopher M.</au><au>Nicholls, Rebecca</au><au>Weston, Adèle R.</au><au>Bampton, Peter</au><au>Sparrow, Miles</au><au>Lawrance, Ian C.</au><au>Selby, Warwick S.</au><au>Andrews, Jane M.</au><au>Walsh, Alissa J.</au><au>Hetzel, David J.</au><au>Macrae, Finlay A.</au><au>Moore, Gregory T.</au><au>Weltman, Martin D.</au><au>Leong, Rupert W.</au><au>Fan, Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study</atitle><jtitle>Journal of Crohn's and colitis</jtitle><addtitle>J Crohns Colitis</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>8</volume><issue>7</issue><spage>598</spage><epage>606</epage><pages>598-606</pages><issn>1873-9946</issn><eissn>1876-4479</eissn><abstract>The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population.
A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life–8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires.
In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps<0.001). IBDQ correlated with both AQoL-8D (r=0.73; P<0.0001) and EQ-5D-5L (0.69; P<0.0001). Mean 3-month UC-related health care cost per patient was AUD $2914 (SD=$3447 [mean for patients in remission=$1970; mild disease=$3736; moderate/severe disease=$4162]). Patients in remission had the least work and activity impairment.
More severe UC disease was associated with poorer QoL. Substantial health care utilization, costs, and work productivity impairments were found in this sample of patients with UC. Moreover, greater disease activity was associated with greater health care costs and impairment in work productivity and daily activities.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>24345767</pmid><doi>10.1016/j.crohns.2013.11.017</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of Crohn's and colitis, 2014-07, Vol.8 (7), p.598-606 |
| issn | 1873-9946 1876-4479 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adolescent Adult Aged Aged, 80 and over Australia Colitis, Ulcerative - economics Colitis, Ulcerative - therapy Cross-Sectional Studies Disease severity Drug Costs Efficiency Female Health Care Costs Health care utilization Health Services - economics Health Services - utilization Hospitalization - economics Humans Male Middle Aged Quality of Life Retrospective Studies Severity of Illness Index Surveys and Questionnaires Ulcerative colitis Utility Work Capacity Evaluation Young Adult |
| title | Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study |
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