A translational medicine appraisal of specialized andrology testing in unexplained male infertility
The diagnostic and prognostic validity of sperm function biomarkers is particularly relevant for males with unexplained infertility in which routine semen analysis fails to detect subcellular sperm dysfunctions. In this general review, we examine the role and significance of specialized andrology la...
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| Veröffentlicht in: | International urology and nephrology 2014-06, Vol.46 (6), p.1037-1052 |
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| container_title | International urology and nephrology |
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| creator | Esteves, Sandro C. Sharma, Rakesh K. Gosálvez, Jaime Agarwal, Ashok |
| description | The diagnostic and prognostic validity of sperm function biomarkers is particularly relevant for males with unexplained infertility in which routine semen analysis fails to detect subcellular sperm dysfunctions. In this general review, we examine the role and significance of specialized andrology laboratory tests from past to present and provide a glance toward the future. We concluded that the assessment of sperm DNA damage and oxidative stress provide a relatively independent measure of fertility that yields diagnostic and prognostic information complementary to, but distinct and more significant than, standard sperm parameters. Since none of the available methods for such testing have been fully translated, further research is necessary to evaluate their cost-effectiveness when applied in large scale to daily medical practice. Application of translational medicine concepts would also be useful to accelerate the clinical application of recent discoveries in the fields of genomics, proteomics and metabolomics. |
| doi_str_mv | 10.1007/s11255-014-0715-0 |
| format | Article |
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Application of translational medicine concepts would also be useful to accelerate the clinical application of recent discoveries in the fields of genomics, proteomics and metabolomics.</description><subject>Acrosome Reaction</subject><subject>DNA Damage</subject><subject>Humans</subject><subject>Infertility, Male - etiology</subject><subject>Infertility, Male - genetics</subject><subject>Infertility, Male - physiopathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Oxidative Stress</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Semen Analysis</subject><subject>Spermatozoa - physiology</subject><subject>Translational Medical Research</subject><subject>Urology</subject><subject>Urology – Review</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUtLxDAUhYMozvj4AW4k4MZN9d6madqliC8Q3Og6pGk6ZMikNWnB8debcVREcBESbr5zbnIPIScIFwggLiNiznkGWGQgMB12yBy5YFnOq2KXzIEBZljmbEYOYlwCQF0B7JNZXgiBhcjnRF_RMSgfnRpt75WjK9Nabb2hahiCsjGV-o7GwWirnH03LVW-Db3rF2s6mjhav6DW08mbt8GpJGzpSjmTap0Jo3V2XB-RvU65aI6_9kPycnvzfH2fPT7dPVxfPWa6EDhmpVF1w5gWDI3OWWnaqqs7xZFXuuVlLaqmEpqBKqGsuCiFTqtmbdfwrsG6YofkfOs7hP51Sm-TKxu1cU55009RImdY8wILltCzP-iyn0L6_ycFPK8FbijcUjr0MQbTySHYlQpriSA3CchtAjIlIDcJSEia0y_nqUmz_FF8jzwB-RaI6covTPjV-l_XDymSkUs</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Esteves, Sandro C.</creator><creator>Sharma, Rakesh K.</creator><creator>Gosálvez, Jaime</creator><creator>Agarwal, Ashok</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>A translational medicine appraisal of specialized andrology testing in unexplained male infertility</title><author>Esteves, Sandro C. ; 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| subjects | Acrosome Reaction DNA Damage Humans Infertility, Male - etiology Infertility, Male - genetics Infertility, Male - physiopathology Male Medicine Medicine & Public Health Nephrology Oxidative Stress Reactive Oxygen Species - metabolism Semen Analysis Spermatozoa - physiology Translational Medical Research Urology Urology – Review |
| title | A translational medicine appraisal of specialized andrology testing in unexplained male infertility |
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