Detection of liver injury in IBD using transient elastography
Up to 5% of inflammatory bowel disease (IBD) patients are thought to have clinically significant liver disease due to multifactorial causes, however, this figure may be an underestimate due to reliance on abnormal liver tests (LTs) and/or liver biopsies. Our aim was to evaluate the prevalence of cli...
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| Veröffentlicht in: | Journal of Crohn's and colitis 2014-07, Vol.8 (7), p.671-677 |
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| container_title | Journal of Crohn's and colitis |
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| creator | Thin, L.W.Y. Lawrance, I.C. Spilsbury, K. Kava, J. Olynyk, J.K. |
| description | Up to 5% of inflammatory bowel disease (IBD) patients are thought to have clinically significant liver disease due to multifactorial causes, however, this figure may be an underestimate due to reliance on abnormal liver tests (LTs) and/or liver biopsies.
Our aim was to evaluate the prevalence of clinically significant liver disease in IBD patients as defined by an increased liver stiffness measurement (LS) ≥8kPa using transient elastography (TE).
110 IBD patients, and 55 non-IBD control subjects, had their LS recorded using FibroScan® (EchoSense, Paris, France) by a single blinded operator trained in TE.
71 Crohn's disease and 39 ulcerative colitis subjects were included. All demographic variables were similar between the IBD and control groups apart from a significantly higher proportion of IBD patients who smoked (17.3% vs 3.6%, P=0.013). Seven IBD patients (6.4%) had an LS over 8kPa and 3 had persistently elevated LS 6months later. One patient had compensated cirrhosis. No significant differences in overall LS were observed between the IBD and control groups. Increased BMI and age, however, were independently associated with a higher LS in the IBD but not in the control group (P |
| doi_str_mv | 10.1016/j.crohns.2013.12.006 |
| format | Article |
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Our aim was to evaluate the prevalence of clinically significant liver disease in IBD patients as defined by an increased liver stiffness measurement (LS) ≥8kPa using transient elastography (TE).
110 IBD patients, and 55 non-IBD control subjects, had their LS recorded using FibroScan® (EchoSense, Paris, France) by a single blinded operator trained in TE.
71 Crohn's disease and 39 ulcerative colitis subjects were included. All demographic variables were similar between the IBD and control groups apart from a significantly higher proportion of IBD patients who smoked (17.3% vs 3.6%, P=0.013). Seven IBD patients (6.4%) had an LS over 8kPa and 3 had persistently elevated LS 6months later. One patient had compensated cirrhosis. No significant differences in overall LS were observed between the IBD and control groups. Increased BMI and age, however, were independently associated with a higher LS in the IBD but not in the control group (P<0.001 and 0.010 respectively).
Using TE, the prevalence of clinically significant liver disease in IBD patients is low. The association of increased BMI and age with increased LS in IBD suggests fatty liver disease being the prevailing aetiology in these patients.</description><identifier>ISSN: 1873-9946</identifier><identifier>EISSN: 1876-4479</identifier><identifier>DOI: 10.1016/j.crohns.2013.12.006</identifier><identifier>PMID: 24529605</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adult ; Age Factors ; Body Mass Index ; Colitis, Ulcerative - complications ; Colitis, Ulcerative - drug therapy ; Crohn Disease - complications ; Crohn Disease - drug therapy ; Cross-Sectional Studies ; Elasticity Imaging Techniques ; Female ; Humans ; IBD ; Liver Diseases - complications ; Liver Diseases - diagnostic imaging ; Liver Diseases - epidemiology ; Liver stiffness ; Male ; Middle Aged ; NAFLD ; Prevalence ; Prospective Studies ; Transient elastography ; Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><ispartof>Journal of Crohn's and colitis, 2014-07, Vol.8 (7), p.671-677</ispartof><rights>2014 European Crohn's and Colitis Organisation</rights><rights>Copyright © 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-3629c44b29e8ae91349cb056ad912a60746d01d12d00e66a387e959c9608b193</citedby><cites>FETCH-LOGICAL-c408t-3629c44b29e8ae91349cb056ad912a60746d01d12d00e66a387e959c9608b193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24529605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thin, L.W.Y.</creatorcontrib><creatorcontrib>Lawrance, I.C.</creatorcontrib><creatorcontrib>Spilsbury, K.</creatorcontrib><creatorcontrib>Kava, J.</creatorcontrib><creatorcontrib>Olynyk, J.K.</creatorcontrib><title>Detection of liver injury in IBD using transient elastography</title><title>Journal of Crohn's and colitis</title><addtitle>J Crohns Colitis</addtitle><description>Up to 5% of inflammatory bowel disease (IBD) patients are thought to have clinically significant liver disease due to multifactorial causes, however, this figure may be an underestimate due to reliance on abnormal liver tests (LTs) and/or liver biopsies.
Our aim was to evaluate the prevalence of clinically significant liver disease in IBD patients as defined by an increased liver stiffness measurement (LS) ≥8kPa using transient elastography (TE).
110 IBD patients, and 55 non-IBD control subjects, had their LS recorded using FibroScan® (EchoSense, Paris, France) by a single blinded operator trained in TE.
71 Crohn's disease and 39 ulcerative colitis subjects were included. All demographic variables were similar between the IBD and control groups apart from a significantly higher proportion of IBD patients who smoked (17.3% vs 3.6%, P=0.013). Seven IBD patients (6.4%) had an LS over 8kPa and 3 had persistently elevated LS 6months later. One patient had compensated cirrhosis. No significant differences in overall LS were observed between the IBD and control groups. Increased BMI and age, however, were independently associated with a higher LS in the IBD but not in the control group (P<0.001 and 0.010 respectively).
Using TE, the prevalence of clinically significant liver disease in IBD patients is low. The association of increased BMI and age with increased LS in IBD suggests fatty liver disease being the prevailing aetiology in these patients.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Body Mass Index</subject><subject>Colitis, Ulcerative - complications</subject><subject>Colitis, Ulcerative - drug therapy</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - drug therapy</subject><subject>Cross-Sectional Studies</subject><subject>Elasticity Imaging Techniques</subject><subject>Female</subject><subject>Humans</subject><subject>IBD</subject><subject>Liver Diseases - complications</subject><subject>Liver Diseases - diagnostic imaging</subject><subject>Liver Diseases - epidemiology</subject><subject>Liver stiffness</subject><subject>Male</subject><subject>Middle Aged</subject><subject>NAFLD</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Transient elastography</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><issn>1873-9946</issn><issn>1876-4479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EoqXwBgjlyCXBdmwnPoAELT-VKnHp3XKcbesoTYqdVOrb45LCkdPsYWZn90PoluCEYCIeqsS4dtP4hGKSJoQmGIszNCZ5JmLGMnn-M6exlEyM0JX3FcZc8iy_RCPKOJUC8zF6nEEHprNtE7WrqLZ7cJFtqt4dgkTzl1nUe9uso87pxltoughq7bt27fRuc7hGFytde7g56QQt316X04948fk-nz4vYsNw3sWpoNIwVlAJuQZJUiZNgbnQpSRUC5wxUWJSElpiDELoNM9AcmnCiXlBZDpB98PanWu_evCd2lpvoK51A23vFeEpkTyVLAtWNlgDHO8drNTO2a12B0WwOnJTlRq4qSM3RagK3ELs7tTQF1so_0K_oILhaTBAeHNvwSlvAg4DpXWBnypb-3_DN6q2fxI</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Thin, L.W.Y.</creator><creator>Lawrance, I.C.</creator><creator>Spilsbury, K.</creator><creator>Kava, J.</creator><creator>Olynyk, J.K.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Detection of liver injury in IBD using transient elastography</title><author>Thin, L.W.Y. ; Lawrance, I.C. ; Spilsbury, K. ; Kava, J. ; Olynyk, J.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-3629c44b29e8ae91349cb056ad912a60746d01d12d00e66a387e959c9608b193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Body Mass Index</topic><topic>Colitis, Ulcerative - complications</topic><topic>Colitis, Ulcerative - drug therapy</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - drug therapy</topic><topic>Cross-Sectional Studies</topic><topic>Elasticity Imaging Techniques</topic><topic>Female</topic><topic>Humans</topic><topic>IBD</topic><topic>Liver Diseases - complications</topic><topic>Liver Diseases - diagnostic imaging</topic><topic>Liver Diseases - epidemiology</topic><topic>Liver stiffness</topic><topic>Male</topic><topic>Middle Aged</topic><topic>NAFLD</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Transient elastography</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thin, L.W.Y.</creatorcontrib><creatorcontrib>Lawrance, I.C.</creatorcontrib><creatorcontrib>Spilsbury, K.</creatorcontrib><creatorcontrib>Kava, J.</creatorcontrib><creatorcontrib>Olynyk, J.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Crohn's and colitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thin, L.W.Y.</au><au>Lawrance, I.C.</au><au>Spilsbury, K.</au><au>Kava, J.</au><au>Olynyk, J.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of liver injury in IBD using transient elastography</atitle><jtitle>Journal of Crohn's and colitis</jtitle><addtitle>J Crohns Colitis</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>8</volume><issue>7</issue><spage>671</spage><epage>677</epage><pages>671-677</pages><issn>1873-9946</issn><eissn>1876-4479</eissn><abstract>Up to 5% of inflammatory bowel disease (IBD) patients are thought to have clinically significant liver disease due to multifactorial causes, however, this figure may be an underestimate due to reliance on abnormal liver tests (LTs) and/or liver biopsies.
Our aim was to evaluate the prevalence of clinically significant liver disease in IBD patients as defined by an increased liver stiffness measurement (LS) ≥8kPa using transient elastography (TE).
110 IBD patients, and 55 non-IBD control subjects, had their LS recorded using FibroScan® (EchoSense, Paris, France) by a single blinded operator trained in TE.
71 Crohn's disease and 39 ulcerative colitis subjects were included. All demographic variables were similar between the IBD and control groups apart from a significantly higher proportion of IBD patients who smoked (17.3% vs 3.6%, P=0.013). Seven IBD patients (6.4%) had an LS over 8kPa and 3 had persistently elevated LS 6months later. One patient had compensated cirrhosis. No significant differences in overall LS were observed between the IBD and control groups. Increased BMI and age, however, were independently associated with a higher LS in the IBD but not in the control group (P<0.001 and 0.010 respectively).
Using TE, the prevalence of clinically significant liver disease in IBD patients is low. The association of increased BMI and age with increased LS in IBD suggests fatty liver disease being the prevailing aetiology in these patients.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>24529605</pmid><doi>10.1016/j.crohns.2013.12.006</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Crohn's and colitis, 2014-07, Vol.8 (7), p.671-677 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Age Factors Body Mass Index Colitis, Ulcerative - complications Colitis, Ulcerative - drug therapy Crohn Disease - complications Crohn Disease - drug therapy Cross-Sectional Studies Elasticity Imaging Techniques Female Humans IBD Liver Diseases - complications Liver Diseases - diagnostic imaging Liver Diseases - epidemiology Liver stiffness Male Middle Aged NAFLD Prevalence Prospective Studies Transient elastography Tumor Necrosis Factor-alpha - antagonists & inhibitors |
| title | Detection of liver injury in IBD using transient elastography |
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