IGF2: an endocrine hormone to improve islet transplant survival

In the week following pancreatic islet transplantation, up to 50% of transplanted islets are lost due to apoptotic cell death triggered by hypoxic and pro-inflammatory cytokine-mediated cell stress. Thus, therapeutic approaches designed to protect islet cells from apoptosis could significantly impro...

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Veröffentlicht in:	Journal of endocrinology 2014-05, Vol.221 (2), p.R41-R48
Hauptverfasser:	Hughes, Amy, Rojas-Canales, Darling, Drogemuller, Chris, Voelcker, Nicolas H, Grey, Shane T, Coates, P T H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Cell Survival - drug effects Diabetes Mellitus, Type 1 - therapy Gene Transfer Techniques Genetic Therapy Graft Survival - drug effects Humans Inflammation Mediators - pharmacology Insulin-Like Growth Factor II - physiology Insulin-Like Growth Factor II - therapeutic use Islets of Langerhans - drug effects Islets of Langerhans - physiology Islets of Langerhans Transplantation Review
Online-Zugang:	Volltext
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