New 2H-chromene-3-carboxamide derivatives: Design, synthesis and use as inhibitors of hMAO

A series new 2H-chromene-3-carboxamide derivatives 4a–4t were synthesized and evaluated as monoamine oxidase A and B (MAO-A and MAO-B) inhibitors. Among them, compound 4d (IC50 = 0.93 μM, IC50 iproniazid = 7.80 μM) showed the most activity and higher MAO-B selectivity (64.5-fold vs. 1-fold) with res...

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Veröffentlicht in:	European journal of medicinal chemistry 2014-06, Vol.80, p.278-284
Hauptverfasser:	Pan, Zhi-Xiang, He, Xu, Chen, Yan-Yan, Tang, Wen-Jian, Shi, Jing-Bo, Tang, Yu-Lan, Song, Bao-An, Li, Jun, Liu, Xin-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzopyrans - chemical synthesis Benzopyrans - chemistry Benzopyrans - metabolism Benzopyrans - pharmacology Chemistry Techniques, Synthetic Coumarin Design Drug Design hMAO-B Humans Inhibitors Inhibitory Concentration 50 Molecular Docking Simulation Monoamine Oxidase - chemistry Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - chemical synthesis Monoamine Oxidase Inhibitors - chemistry Monoamine Oxidase Inhibitors - metabolism Monoamine Oxidase Inhibitors - pharmacology Synthesis
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