Pharmaceutical approaches involving carvedilol characterization, compatibility with different excipients and kinetic studies
This study was performed to investigate the physical–chemical characteristics of carvedilol (CRV), complemented by compatibility studies with a great variety of pharmaceutical excipients. Thermogravimetry and differential scanning calorimetry, supported by diffuse reflectance infrared fourier transf...
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| Veröffentlicht in: | Journal of thermal analysis and calorimetry 2014-03, Vol.115 (3), p.2507-2515 |
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| creator | Borba, Paola Aline Amarante Vecchia, Debora Dalla Riekes, Manoela Klüppel Pereira, Rafael Nicolay Tagliari, Monika Piazzon Silva, Marcos Antonio Segatto Cuffini, Silvia Lucia de Campos, Carlos Eduardo Maduro Stulzer, Hellen Karine |
| description | This study was performed to investigate the physical–chemical characteristics of carvedilol (CRV), complemented by compatibility studies with a great variety of pharmaceutical excipients. Thermogravimetry and differential scanning calorimetry, supported by diffuse reflectance infrared fourier transform spectroscopy (DRIFT), X-ray powder diffraction, and scanning electron microscopy (SEM) were selected as the solid-state techniques for the intended analyses. In addition, non-isothermal methods were employed to investigate kinetic data of CRV decomposition process under nitrogen and air atmospheres. CRV is characterized by an endothermic sharp event (
T
peak
= 389.81 K and Δ
H
fusion
of −176.28 J g
−1
) and a thermal decomposition behavior in two stages, totalizing 98 % of mass loss. The CRV pattern diffraction presents prominent peaks at 2
θ
: 5.92°, 14.90°, 18.62°, 24.47°, and 26.30°, and the DRIFT spectrum showed the main characteristics bands for CRV chemical functional groups. The SEM photomicrographs demonstrate that CRV is characterized by irregular blocky shaped crystals. Zero order kinetics was determined by Ozawa method in both nitrogen and air atmospheres. The compatibility results showed no evidence of any incompatibility among CRV and all the excipients analyzed. |
| doi_str_mv | 10.1007/s10973-014-3640-7 |
| format | Article |
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T
peak
= 389.81 K and Δ
H
fusion
of −176.28 J g
−1
) and a thermal decomposition behavior in two stages, totalizing 98 % of mass loss. The CRV pattern diffraction presents prominent peaks at 2
θ
: 5.92°, 14.90°, 18.62°, 24.47°, and 26.30°, and the DRIFT spectrum showed the main characteristics bands for CRV chemical functional groups. The SEM photomicrographs demonstrate that CRV is characterized by irregular blocky shaped crystals. Zero order kinetics was determined by Ozawa method in both nitrogen and air atmospheres. The compatibility results showed no evidence of any incompatibility among CRV and all the excipients analyzed.</description><identifier>ISSN: 1388-6150</identifier><identifier>EISSN: 1588-2926</identifier><identifier>EISSN: 1572-8943</identifier><identifier>DOI: 10.1007/s10973-014-3640-7</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Analysis ; Analytical Chemistry ; Atmospheres ; Calorimetry ; Chemistry ; Chemistry and Materials Science ; Diffraction ; Drift ; Endothermic reactions ; Excipients ; Inorganic Chemistry ; Measurement Science and Instrumentation ; Pharmaceutical industry ; Pharmaceuticals ; Physical Chemistry ; Polymer Sciences ; Reflectance ; Scanning electron microscopy ; X-rays</subject><ispartof>Journal of thermal analysis and calorimetry, 2014-03, Vol.115 (3), p.2507-2515</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-7de8803580b8c2c7110408d4e0daa7f12da5ac562e1741bd1762c67034c699a83</citedby><cites>FETCH-LOGICAL-c459t-7de8803580b8c2c7110408d4e0daa7f12da5ac562e1741bd1762c67034c699a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10973-014-3640-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10973-014-3640-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Borba, Paola Aline Amarante</creatorcontrib><creatorcontrib>Vecchia, Debora Dalla</creatorcontrib><creatorcontrib>Riekes, Manoela Klüppel</creatorcontrib><creatorcontrib>Pereira, Rafael Nicolay</creatorcontrib><creatorcontrib>Tagliari, Monika Piazzon</creatorcontrib><creatorcontrib>Silva, Marcos Antonio Segatto</creatorcontrib><creatorcontrib>Cuffini, Silvia Lucia</creatorcontrib><creatorcontrib>de Campos, Carlos Eduardo Maduro</creatorcontrib><creatorcontrib>Stulzer, Hellen Karine</creatorcontrib><title>Pharmaceutical approaches involving carvedilol characterization, compatibility with different excipients and kinetic studies</title><title>Journal of thermal analysis and calorimetry</title><addtitle>J Therm Anal Calorim</addtitle><description>This study was performed to investigate the physical–chemical characteristics of carvedilol (CRV), complemented by compatibility studies with a great variety of pharmaceutical excipients. Thermogravimetry and differential scanning calorimetry, supported by diffuse reflectance infrared fourier transform spectroscopy (DRIFT), X-ray powder diffraction, and scanning electron microscopy (SEM) were selected as the solid-state techniques for the intended analyses. In addition, non-isothermal methods were employed to investigate kinetic data of CRV decomposition process under nitrogen and air atmospheres. CRV is characterized by an endothermic sharp event (
T
peak
= 389.81 K and Δ
H
fusion
of −176.28 J g
−1
) and a thermal decomposition behavior in two stages, totalizing 98 % of mass loss. The CRV pattern diffraction presents prominent peaks at 2
θ
: 5.92°, 14.90°, 18.62°, 24.47°, and 26.30°, and the DRIFT spectrum showed the main characteristics bands for CRV chemical functional groups. The SEM photomicrographs demonstrate that CRV is characterized by irregular blocky shaped crystals. Zero order kinetics was determined by Ozawa method in both nitrogen and air atmospheres. The compatibility results showed no evidence of any incompatibility among CRV and all the excipients analyzed.</description><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Atmospheres</subject><subject>Calorimetry</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Diffraction</subject><subject>Drift</subject><subject>Endothermic reactions</subject><subject>Excipients</subject><subject>Inorganic Chemistry</subject><subject>Measurement Science and Instrumentation</subject><subject>Pharmaceutical industry</subject><subject>Pharmaceuticals</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Reflectance</subject><subject>Scanning electron microscopy</subject><subject>X-rays</subject><issn>1388-6150</issn><issn>1588-2926</issn><issn>1572-8943</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kV9r1TAYh4s4cG5-AO8C3ijYmbdpm_ZyDP8MBsqm1yEneXvOO9ukJulxEz-8OdSbAyK5yI_wPAlvfkXxEvgFcC7fReC9FCWHuhRtzUv5pDiFpuvKqq_apzmLnFto-LPieYz3nPO-53Ba_P6y02HSBpdERo9Mz3Pw2uwwMnJ7P-7JbZnRYY-WRj8yk3FtEgb6pRN595YZP805bmik9Mh-UtoxS8OAAV1i-GBoppwi086y7-Qwv8NiWixhPC9OBj1GfPF3Pyu-fXj_9epTefP54_XV5U1p6qZPpbTYdVw0Hd90pjISgNe8szVyq7UcoLK60aZpKwRZw8aCbCvTSi5q0_a97sRZ8Xq9N8_2Y8GY1ETR4Dhqh36JChoBHKSomoy-WtGtHlGRG3zK8x5wdSkkVJ2o6zZTF_-g8rI4kfEOB8rnR8KbIyEzCR_SVi8xquu722MWVtYEH2PAQc2BJh0eFXB1KFutZatctjqUrWR2qtWJmXVbDOreL8HlT_2P9AeXk60s</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Borba, Paola Aline Amarante</creator><creator>Vecchia, Debora Dalla</creator><creator>Riekes, Manoela Klüppel</creator><creator>Pereira, Rafael Nicolay</creator><creator>Tagliari, Monika Piazzon</creator><creator>Silva, Marcos Antonio Segatto</creator><creator>Cuffini, Silvia Lucia</creator><creator>de Campos, Carlos Eduardo Maduro</creator><creator>Stulzer, Hellen Karine</creator><general>Springer Netherlands</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140301</creationdate><title>Pharmaceutical approaches involving carvedilol characterization, compatibility with different excipients and kinetic studies</title><author>Borba, Paola Aline Amarante ; Vecchia, Debora Dalla ; Riekes, Manoela Klüppel ; Pereira, Rafael Nicolay ; Tagliari, Monika Piazzon ; Silva, Marcos Antonio Segatto ; Cuffini, Silvia Lucia ; de Campos, Carlos Eduardo Maduro ; Stulzer, Hellen Karine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-7de8803580b8c2c7110408d4e0daa7f12da5ac562e1741bd1762c67034c699a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Atmospheres</topic><topic>Calorimetry</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Diffraction</topic><topic>Drift</topic><topic>Endothermic reactions</topic><topic>Excipients</topic><topic>Inorganic Chemistry</topic><topic>Measurement Science and Instrumentation</topic><topic>Pharmaceutical industry</topic><topic>Pharmaceuticals</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Reflectance</topic><topic>Scanning electron microscopy</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borba, Paola Aline Amarante</creatorcontrib><creatorcontrib>Vecchia, Debora Dalla</creatorcontrib><creatorcontrib>Riekes, Manoela Klüppel</creatorcontrib><creatorcontrib>Pereira, Rafael Nicolay</creatorcontrib><creatorcontrib>Tagliari, Monika Piazzon</creatorcontrib><creatorcontrib>Silva, Marcos Antonio Segatto</creatorcontrib><creatorcontrib>Cuffini, Silvia Lucia</creatorcontrib><creatorcontrib>de Campos, Carlos Eduardo Maduro</creatorcontrib><creatorcontrib>Stulzer, Hellen Karine</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of thermal analysis and calorimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borba, Paola Aline Amarante</au><au>Vecchia, Debora Dalla</au><au>Riekes, Manoela Klüppel</au><au>Pereira, Rafael Nicolay</au><au>Tagliari, Monika Piazzon</au><au>Silva, Marcos Antonio Segatto</au><au>Cuffini, Silvia Lucia</au><au>de Campos, Carlos Eduardo Maduro</au><au>Stulzer, Hellen Karine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmaceutical approaches involving carvedilol characterization, compatibility with different excipients and kinetic studies</atitle><jtitle>Journal of thermal analysis and calorimetry</jtitle><stitle>J Therm Anal Calorim</stitle><date>2014-03-01</date><risdate>2014</risdate><volume>115</volume><issue>3</issue><spage>2507</spage><epage>2515</epage><pages>2507-2515</pages><issn>1388-6150</issn><eissn>1588-2926</eissn><eissn>1572-8943</eissn><abstract>This study was performed to investigate the physical–chemical characteristics of carvedilol (CRV), complemented by compatibility studies with a great variety of pharmaceutical excipients. Thermogravimetry and differential scanning calorimetry, supported by diffuse reflectance infrared fourier transform spectroscopy (DRIFT), X-ray powder diffraction, and scanning electron microscopy (SEM) were selected as the solid-state techniques for the intended analyses. In addition, non-isothermal methods were employed to investigate kinetic data of CRV decomposition process under nitrogen and air atmospheres. CRV is characterized by an endothermic sharp event (
T
peak
= 389.81 K and Δ
H
fusion
of −176.28 J g
−1
) and a thermal decomposition behavior in two stages, totalizing 98 % of mass loss. The CRV pattern diffraction presents prominent peaks at 2
θ
: 5.92°, 14.90°, 18.62°, 24.47°, and 26.30°, and the DRIFT spectrum showed the main characteristics bands for CRV chemical functional groups. The SEM photomicrographs demonstrate that CRV is characterized by irregular blocky shaped crystals. Zero order kinetics was determined by Ozawa method in both nitrogen and air atmospheres. The compatibility results showed no evidence of any incompatibility among CRV and all the excipients analyzed.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10973-014-3640-7</doi><tpages>9</tpages></addata></record> |
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| language | eng |
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| source | SpringerNature Journals |
| subjects | Analysis Analytical Chemistry Atmospheres Calorimetry Chemistry Chemistry and Materials Science Diffraction Drift Endothermic reactions Excipients Inorganic Chemistry Measurement Science and Instrumentation Pharmaceutical industry Pharmaceuticals Physical Chemistry Polymer Sciences Reflectance Scanning electron microscopy X-rays |
| title | Pharmaceutical approaches involving carvedilol characterization, compatibility with different excipients and kinetic studies |
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