Simultaneous determination of sesquiterpene lactones isoalantolactone and alantolactone isomers in rat plasma by liquid chromatography with tandem mass spectrometry: Application to a pharmacokinetic study

A selective, sensitive, and accurate LC–MS/MS method for the simultaneous determination of isoalantolactone and alantolactone in rat plasma has been developed using psoralen as the internal standard. LC–MS/MS analysis was carried out on a Triple Quadrupole mass spectrometer using positive ion ESI an...

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Veröffentlicht in:	Journal of separation science 2014-04, Vol.37 (8), p.950-956
Hauptverfasser:	Guo, Chunjie, Zhang, Sixi, Teng, Shiyong, Niu, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Alantolactone Animals Assaying Biological and medical sciences Chromatography Chromatography, Liquid Food and Drug Administration General pharmacology Guidelines intravenous injection Inula helenium Ions Isoalantolactone Isomers Kinetics Lactones Lactones - blood Lactones - pharmacokinetics LC-MS/MS liquid chromatography Male Mass spectrometers Mass spectrometry Medical sciences Molecular Structure Monitoring Pharmacognosy. Homeopathy. Health food Pharmacokinetics Pharmacology Pharmacology. Drug treatments Quadrupoles Rats Rats, Sprague-Dawley Rodents Sesquiterpenes - blood Sesquiterpenes - pharmacokinetics Sesquiterpenes, Eudesmane - blood Sesquiterpenes, Eudesmane - pharmacokinetics sesquiterpenoid lactones spectrometers Stereoisomerism Tandem Mass Spectrometry Traditional Chinese medicine
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