Stereoselective analysis of nebivolol isomers in human plasma by high-performance liquid chromatography–tandem mass spectrometry: Application in pharmacokinetics

•The article describes the stereoselective analysis of nebivolol in human plasma.•The validated method showed quantification limit of 25pg of each isomer/mL plasma.•The method was applied in a pharmacokinetic study of a single dose of nebivolol.•Plasma nebivolol isomers were quantified until 48h aft...

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Veröffentlicht in:Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2013-12, Vol.940, p.47-52
Hauptverfasser: Neves, Daniel Valente, Vieira, Carolina Pinto, Coelho, Eduardo Barbosa, Marques, Maria Paula, Lanchote, Vera Lucia
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Sprache:eng
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