Mobilization of Cd from human serum albumin by small molecular weight thiols

•LC was applied to study the stability of a Cd–human serum albumin (HSA) complex.•Cd–HSA complex was injected on SEC column and Cd was detected in effluent.•Effect of small molecular weight thiols in mobile phase on Cd-elution investigated.•At 1.0mM in mobile phase Cys and GSH were more effective th...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2014-05, Vol.958, p.16-21
Hauptverfasser:	Morris, Thomas T., Keir, Jennifer L.A., Boshart, Steven J., Lobanov, Victor P., Ruhland, Anthony M.A., Bahl, Nishita, Gailer, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - metabolism Albumin Cadmium Cadmium - metabolism Cd-specific detection Chromatography, Gel - methods Chromatography, High Pressure Liquid - methods Cysteine - metabolism Elution Glutathione - metabolism Human Humans Hyphenation Organs Phosphates Protein Binding Proteins SEC Serum albumin Serum Albumin - metabolism Small molecular weight thiol Sulfhydryl Compounds - metabolism Target organ
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