The development of an analytical method for urinary metabolites of the riot control agent 2-chlorobenzylidene malononitrile (CS)

•A sensitive analytical method for 2-chlorohippuric acid in urine is reported.•2-Chlorohippuric acid is a human urinary metabolite of the riot control agent CS.•2-Chlorohippuric acid can be detected in human urine 20h after mild exposures to CS.•2-Chlorobenzyl-N-acetylcysteine, a CS metabolite in th...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2013-06, Vol.928, p.125-130
Hauptverfasser:	Riches, James R., Read, Robert W., Black, Robin M., Harrison, John M., Shand, Dawn A., Tomsett, Eleanor V., Newsome, Catherine R., Bailey, Nicola C., Roughley, Neil, Gravett, Matthew R., Stubbs, Sarah J., McColm, Richard R.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Chlorobenzylidene malononitrile 2-Chlorohippuric acid Adolescent Adult Animals Blood chromatography Chromatography, Liquid - methods detection limit Hippurates - urine Humans illicit drugs LC/MS/MS Limit of Detection Low level Male Malononitrile Mathematical analysis Metabolites Monitoring o-Chlorobenzylidenemalonitrile - administration & dosage o-Chlorobenzylidenemalonitrile - metabolism o-Chlorobenzylidenemalonitrile - urine occupational exposure poisoning Rats Riot control agents Riot Control Agents, Chemical - administration & dosage Riot Control Agents, Chemical - metabolism Riot Control Agents, Chemical - urine Riots sports Tandem Mass Spectrometry - methods Tear gas Urine Young Adult
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