Evaluation of friction properties of hydrogels based on a biphasic cartilage model
Characterizing hydrogels using a biphasic cartilage model, which can predict their behavior based on structural properties, such as permeability and aggregate modulus, may be useful for comparing active lubrication modes of cartilage and hydrogels for the design of articular cartilage implants. The...
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| Veröffentlicht in: | Journal of the mechanical behavior of biomedical materials 2013-12, Vol.28, p.263-273 |
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| creator | Baykal, D. Underwood, R.J. Mansmann, K. Marcolongo, M. Kurtz, S.M. |
| description | Characterizing hydrogels using a biphasic cartilage model, which can predict their behavior based on structural properties, such as permeability and aggregate modulus, may be useful for comparing active lubrication modes of cartilage and hydrogels for the design of articular cartilage implants. The effects of interstitial fluid pressurization, inherent matrix viscoelasticity and tension–compression nonlinearity on mechanical properties of the biphasic material were evaluated by linear biphasic (KLM), biphasic poroviscoelastic (BPVE) and linear biphasic with anisotropy cartilage models, respectively. The BPVE model yielded the lowest root mean square error and highest coefficient of determination when predicting confined and unconfined compression stress–relaxation response of hydrogels (n=15): 0.220±0.316MPa and 0.93±0.08; and 0.017±0.008MPa and 0.98±0.01 respectively. Since the differences in error between models were not statistically significant, the simplest model we considered, KLM model, was sufficient to predict the mechanical response of this family of hydrogels. The coefficient of friction (COF) of a hydrogel–ceramic articulation was measured at varying loads and pressures to explore the full range of lubrication behavior of hydrogel. Material parameters obtained by biphasic models correlated with COF. Based on the linear biphasic model, COF correlated positively with aggregate modulus (spearman's rho=0.5; p |
| doi_str_mv | 10.1016/j.jmbbm.2013.07.022 |
| format | Article |
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[Display omitted]
•Comparing hydrogel and cartilage lubrication is necessary for the design of implants.•Biphasic cartilage models predicted hydrogel mechanical response in compression.•Linear biphasic model was as successful as poroviscoelastic and anisotropic models.•Coefficient of friction of hydrogel increased with velocity and decreased with load.•Viscoelasticity and lubrication of hydrogel depended on interstitial fluid pressurization.</description><identifier>ISSN: 1751-6161</identifier><identifier>EISSN: 1878-0180</identifier><identifier>DOI: 10.1016/j.jmbbm.2013.07.022</identifier><identifier>PMID: 24008138</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Anisotropy ; Articular cartilage ; Cartilage ; Cartilage, Articular - metabolism ; Coefficient of friction ; Correlation ; Elasticity ; Fluid flow ; Friction ; Hydrogel ; Hydrogels ; Hydrogels - metabolism ; Interstitials ; Linear Models ; Lubrication ; Materials Testing ; Mathematical models ; Models, Biological ; Surgical implants ; Tribology ; Viscosity</subject><ispartof>Journal of the mechanical behavior of biomedical materials, 2013-12, Vol.28, p.263-273</ispartof><rights>2013 Elsevier Ltd</rights><rights>2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-710a10d3329f5c5bf10df21ef1a34d37f247dc70d5a090a1ebeae90c6e30eb353</citedby><cites>FETCH-LOGICAL-c458t-710a10d3329f5c5bf10df21ef1a34d37f247dc70d5a090a1ebeae90c6e30eb353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jmbbm.2013.07.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24008138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baykal, D.</creatorcontrib><creatorcontrib>Underwood, R.J.</creatorcontrib><creatorcontrib>Mansmann, K.</creatorcontrib><creatorcontrib>Marcolongo, M.</creatorcontrib><creatorcontrib>Kurtz, S.M.</creatorcontrib><title>Evaluation of friction properties of hydrogels based on a biphasic cartilage model</title><title>Journal of the mechanical behavior of biomedical materials</title><addtitle>J Mech Behav Biomed Mater</addtitle><description>Characterizing hydrogels using a biphasic cartilage model, which can predict their behavior based on structural properties, such as permeability and aggregate modulus, may be useful for comparing active lubrication modes of cartilage and hydrogels for the design of articular cartilage implants. The effects of interstitial fluid pressurization, inherent matrix viscoelasticity and tension–compression nonlinearity on mechanical properties of the biphasic material were evaluated by linear biphasic (KLM), biphasic poroviscoelastic (BPVE) and linear biphasic with anisotropy cartilage models, respectively. The BPVE model yielded the lowest root mean square error and highest coefficient of determination when predicting confined and unconfined compression stress–relaxation response of hydrogels (n=15): 0.220±0.316MPa and 0.93±0.08; and 0.017±0.008MPa and 0.98±0.01 respectively. Since the differences in error between models were not statistically significant, the simplest model we considered, KLM model, was sufficient to predict the mechanical response of this family of hydrogels. The coefficient of friction (COF) of a hydrogel–ceramic articulation was measured at varying loads and pressures to explore the full range of lubrication behavior of hydrogel. Material parameters obtained by biphasic models correlated with COF. Based on the linear biphasic model, COF correlated positively with aggregate modulus (spearman's rho=0.5; p<0.001) and velocity (rho=0.3; p<0.001), and negatively with permeability (rho=−0.3; p<0.001) and load (rho=−0.6; p<0.001). Negative correlation of COF with load and positive correlation with velocity indicated that hydrogel–ceramic articulation was separated by a fluid film. These results together suggested that interstitial fluid pressurization was dominant in the viscoelasticity and lubrication properties of this biphasic material.
[Display omitted]
•Comparing hydrogel and cartilage lubrication is necessary for the design of implants.•Biphasic cartilage models predicted hydrogel mechanical response in compression.•Linear biphasic model was as successful as poroviscoelastic and anisotropic models.•Coefficient of friction of hydrogel increased with velocity and decreased with load.•Viscoelasticity and lubrication of hydrogel depended on interstitial fluid pressurization.</description><subject>Anisotropy</subject><subject>Articular cartilage</subject><subject>Cartilage</subject><subject>Cartilage, Articular - metabolism</subject><subject>Coefficient of friction</subject><subject>Correlation</subject><subject>Elasticity</subject><subject>Fluid flow</subject><subject>Friction</subject><subject>Hydrogel</subject><subject>Hydrogels</subject><subject>Hydrogels - metabolism</subject><subject>Interstitials</subject><subject>Linear Models</subject><subject>Lubrication</subject><subject>Materials Testing</subject><subject>Mathematical models</subject><subject>Models, Biological</subject><subject>Surgical implants</subject><subject>Tribology</subject><subject>Viscosity</subject><issn>1751-6161</issn><issn>1878-0180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMo3p9AkC7dtJ6TNL0sXIiMFxAE0XVIkxPN0E7HpCP49mYcdamr_Dl858LH2AlCgYDV-byYD103FBxQFFAXwPkW28embnLABrZTriXmFVa4xw5inANUAE2zy_Z4mQKKZp89zt51v9KTHxfZ6DIXvPnKyzAuKUye4rr8-mHD-EJ9zDodyWYJ0Fnnl686epMZncBev1A2jJb6I7bjdB_p-Ps9ZM_Xs6er2_z-4ebu6vI-N6VsprxG0AhWCN46aWTn0sdxJIdalFbUjpe1NTVYqaFNKHWkqQVTkQDqhBSH7GwzN936tqI4qcFHQ32vFzSuokIpoG2biuP_aClbWfENKjaoCWOMgZxaBj_o8KEQ1Nq7mqsv72rtXUGtkvfUdfq9YNUNZH97fkQn4GIDJIn07imoaDwtDFkfyEzKjv7PBZ8CqJS_</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Baykal, D.</creator><creator>Underwood, R.J.</creator><creator>Mansmann, K.</creator><creator>Marcolongo, M.</creator><creator>Kurtz, S.M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QQ</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20131201</creationdate><title>Evaluation of friction properties of hydrogels based on a biphasic cartilage model</title><author>Baykal, D. ; Underwood, R.J. ; Mansmann, K. ; Marcolongo, M. ; Kurtz, S.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-710a10d3329f5c5bf10df21ef1a34d37f247dc70d5a090a1ebeae90c6e30eb353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anisotropy</topic><topic>Articular cartilage</topic><topic>Cartilage</topic><topic>Cartilage, Articular - metabolism</topic><topic>Coefficient of friction</topic><topic>Correlation</topic><topic>Elasticity</topic><topic>Fluid flow</topic><topic>Friction</topic><topic>Hydrogel</topic><topic>Hydrogels</topic><topic>Hydrogels - metabolism</topic><topic>Interstitials</topic><topic>Linear Models</topic><topic>Lubrication</topic><topic>Materials Testing</topic><topic>Mathematical models</topic><topic>Models, Biological</topic><topic>Surgical implants</topic><topic>Tribology</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baykal, D.</creatorcontrib><creatorcontrib>Underwood, R.J.</creatorcontrib><creatorcontrib>Mansmann, K.</creatorcontrib><creatorcontrib>Marcolongo, M.</creatorcontrib><creatorcontrib>Kurtz, S.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Ceramic Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baykal, D.</au><au>Underwood, R.J.</au><au>Mansmann, K.</au><au>Marcolongo, M.</au><au>Kurtz, S.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of friction properties of hydrogels based on a biphasic cartilage model</atitle><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle><addtitle>J Mech Behav Biomed Mater</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>28</volume><spage>263</spage><epage>273</epage><pages>263-273</pages><issn>1751-6161</issn><eissn>1878-0180</eissn><abstract>Characterizing hydrogels using a biphasic cartilage model, which can predict their behavior based on structural properties, such as permeability and aggregate modulus, may be useful for comparing active lubrication modes of cartilage and hydrogels for the design of articular cartilage implants. The effects of interstitial fluid pressurization, inherent matrix viscoelasticity and tension–compression nonlinearity on mechanical properties of the biphasic material were evaluated by linear biphasic (KLM), biphasic poroviscoelastic (BPVE) and linear biphasic with anisotropy cartilage models, respectively. The BPVE model yielded the lowest root mean square error and highest coefficient of determination when predicting confined and unconfined compression stress–relaxation response of hydrogels (n=15): 0.220±0.316MPa and 0.93±0.08; and 0.017±0.008MPa and 0.98±0.01 respectively. Since the differences in error between models were not statistically significant, the simplest model we considered, KLM model, was sufficient to predict the mechanical response of this family of hydrogels. The coefficient of friction (COF) of a hydrogel–ceramic articulation was measured at varying loads and pressures to explore the full range of lubrication behavior of hydrogel. Material parameters obtained by biphasic models correlated with COF. Based on the linear biphasic model, COF correlated positively with aggregate modulus (spearman's rho=0.5; p<0.001) and velocity (rho=0.3; p<0.001), and negatively with permeability (rho=−0.3; p<0.001) and load (rho=−0.6; p<0.001). Negative correlation of COF with load and positive correlation with velocity indicated that hydrogel–ceramic articulation was separated by a fluid film. These results together suggested that interstitial fluid pressurization was dominant in the viscoelasticity and lubrication properties of this biphasic material.
[Display omitted]
•Comparing hydrogel and cartilage lubrication is necessary for the design of implants.•Biphasic cartilage models predicted hydrogel mechanical response in compression.•Linear biphasic model was as successful as poroviscoelastic and anisotropic models.•Coefficient of friction of hydrogel increased with velocity and decreased with load.•Viscoelasticity and lubrication of hydrogel depended on interstitial fluid pressurization.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>24008138</pmid><doi>10.1016/j.jmbbm.2013.07.022</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of the mechanical behavior of biomedical materials, 2013-12, Vol.28, p.263-273 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Anisotropy Articular cartilage Cartilage Cartilage, Articular - metabolism Coefficient of friction Correlation Elasticity Fluid flow Friction Hydrogel Hydrogels Hydrogels - metabolism Interstitials Linear Models Lubrication Materials Testing Mathematical models Models, Biological Surgical implants Tribology Viscosity |
| title | Evaluation of friction properties of hydrogels based on a biphasic cartilage model |
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