Rapid determination of natural and synthetic hormones in biosolids and poultry manure by isotope dilution GC–MS/MS
The release of hormones into the environment due to land application of biosolids and manure is a cause of concern for their potential impacts. This paper presents the development of a rapid and sensitive method, based on extraction, for the analysis of 13 hormones in biosolids and poultry manure. A...
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| Veröffentlicht in: | Journal of separation science 2014-04, Vol.37 (7), p.811-819 |
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| container_title | Journal of separation science |
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| creator | Albero, Beatriz Sánchez‐Brunete, Consuelo Miguel, Esther Aznar, Ramón Tadeo, José L |
| description | The release of hormones into the environment due to land application of biosolids and manure is a cause of concern for their potential impacts. This paper presents the development of a rapid and sensitive method, based on extraction, for the analysis of 13 hormones in biosolids and poultry manure. A simultaneous derivatization of hydroxyl and ketone groups was carried out for the determination of hormones by GC–MS/MS. The method was validated in three matrices (sewage sludge, manure, and broiler litter). Recoveries from spiked samples at three concentration levels (50, 25, and 10 ng/g) ranged from 76 to 124% with relative SDs ≤ 16%. Method detection limits for the three matrices were in the range of 0.5–3.0 ng/g dry weight. The optimized method was applied to biosolid and poultry manure samples collected in Spain. Only seven of the 13 studied hormones were detected in the different samples. trans‐Androsterone was detected at high levels (up to 3.1 μg/g in biosolid samples). Estrone and estradiol were the two hormones detected at higher levels in layer manure, whereas estrone and 4‐androstene‐3,17‐dione presented the highest levels in broiler litter. |
| doi_str_mv | 10.1002/jssc.201301037 |
| format | Article |
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This paper presents the development of a rapid and sensitive method, based on extraction, for the analysis of 13 hormones in biosolids and poultry manure. A simultaneous derivatization of hydroxyl and ketone groups was carried out for the determination of hormones by GC–MS/MS. The method was validated in three matrices (sewage sludge, manure, and broiler litter). Recoveries from spiked samples at three concentration levels (50, 25, and 10 ng/g) ranged from 76 to 124% with relative SDs ≤ 16%. Method detection limits for the three matrices were in the range of 0.5–3.0 ng/g dry weight. The optimized method was applied to biosolid and poultry manure samples collected in Spain. Only seven of the 13 studied hormones were detected in the different samples. trans‐Androsterone was detected at high levels (up to 3.1 μg/g in biosolid samples). Estrone and estradiol were the two hormones detected at higher levels in layer manure, whereas estrone and 4‐androstene‐3,17‐dione presented the highest levels in broiler litter.</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.201301037</identifier><identifier>PMID: 24812694</identifier><language>eng</language><publisher>Weinheim: Blackwell Publishing Ltd</publisher><subject>Analysis methods ; Analytical chemistry ; Applied sciences ; Biological Products - analysis ; biosolids ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography ; Chromatography, Gas ; Composting ; derivatization ; detection limit ; Dilution ; Drying ; estradiol ; estrone ; Exact sciences and technology ; Gas chromatographic methods ; Gas chromatography-tandem mass spectrometry ; Hormones ; Hormones - analysis ; Indicator Dilution Techniques ; isotope dilution technique ; Isotope Labeling ; Isotopes ; Ketones ; land application ; Litter ; Manure ; Manure - analysis ; Manures ; Mass spectrometry ; Pollution ; Poultry ; Poultry manure ; QuEChERS ; Sewage sludge ; Sex hormones ; Sludge ; Soil Pollutants - chemistry ; synthetic hormones ; Tandem Mass Spectrometry ; Wastes</subject><ispartof>Journal of separation science, 2014-04, Vol.37 (7), p.811-819</ispartof><rights>2014 WILEY‐VCH Verlag GmbH & Co. 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Sep. Science</addtitle><description>The release of hormones into the environment due to land application of biosolids and manure is a cause of concern for their potential impacts. This paper presents the development of a rapid and sensitive method, based on extraction, for the analysis of 13 hormones in biosolids and poultry manure. A simultaneous derivatization of hydroxyl and ketone groups was carried out for the determination of hormones by GC–MS/MS. The method was validated in three matrices (sewage sludge, manure, and broiler litter). Recoveries from spiked samples at three concentration levels (50, 25, and 10 ng/g) ranged from 76 to 124% with relative SDs ≤ 16%. Method detection limits for the three matrices were in the range of 0.5–3.0 ng/g dry weight. The optimized method was applied to biosolid and poultry manure samples collected in Spain. Only seven of the 13 studied hormones were detected in the different samples. trans‐Androsterone was detected at high levels (up to 3.1 μg/g in biosolid samples). Estrone and estradiol were the two hormones detected at higher levels in layer manure, whereas estrone and 4‐androstene‐3,17‐dione presented the highest levels in broiler litter.</description><subject>Analysis methods</subject><subject>Analytical chemistry</subject><subject>Applied sciences</subject><subject>Biological Products - analysis</subject><subject>biosolids</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography</subject><subject>Chromatography, Gas</subject><subject>Composting</subject><subject>derivatization</subject><subject>detection limit</subject><subject>Dilution</subject><subject>Drying</subject><subject>estradiol</subject><subject>estrone</subject><subject>Exact sciences and technology</subject><subject>Gas chromatographic methods</subject><subject>Gas chromatography-tandem mass spectrometry</subject><subject>Hormones</subject><subject>Hormones - analysis</subject><subject>Indicator Dilution Techniques</subject><subject>isotope dilution technique</subject><subject>Isotope Labeling</subject><subject>Isotopes</subject><subject>Ketones</subject><subject>land application</subject><subject>Litter</subject><subject>Manure</subject><subject>Manure - analysis</subject><subject>Manures</subject><subject>Mass spectrometry</subject><subject>Pollution</subject><subject>Poultry</subject><subject>Poultry manure</subject><subject>QuEChERS</subject><subject>Sewage sludge</subject><subject>Sex hormones</subject><subject>Sludge</subject><subject>Soil Pollutants - chemistry</subject><subject>synthetic hormones</subject><subject>Tandem Mass Spectrometry</subject><subject>Wastes</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0c2O0zAQB_AIgdgPuHIES2glLumO48TJHFeFLaBukSgLEhfLcWzWJYmLnQh64x14Q54Ed1uKxAVOnsNv_uPRJMkjChMKkJ2vQlCTDCgDCqy8kxxTTosUGc3vHmrgR8lJCCsAWlYI95OjLK9oxjE_Toa3cm0b0uhB-872crCuJ86QWI1etkT2DQmbfrjRg1XkxvnO9ToQ25PauuBa24Rbs3ZjO_gN6WQ_ek3qDbHBDW6tSWPb8TZ1Nv35_cfV8vxq-SC5Z2Qb9MP9e5pcX754N32Zzt_MXk0v5qkqGJSpUqwyQCloiphxzmtEVTZ1gabgui4xo03cmyNj2lQAyE1e0EICKgNZadhp8myXu_buy6jDIDoblG5b2Ws3BkHjGMQcS_wPmrEcCl4VkT79i67c6Pu4SFQ0ZlJW0qgmO6W8C8FrI9bedtJvBAWxPZ3Ynk4cThcbHu9jx7rTzYH_vlUEZ3sgg5Kt8bJXNvxxFcMMGY8u37mvttWbf4wVr5fLaWzazk93bTYM-tuhTfrPgpesLMSHxUzwy8Vi_jz7KN5H_2TnjXRCfvLxK9fLmJsDQIUIyH4BjwnJlA</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Albero, Beatriz</creator><creator>Sánchez‐Brunete, Consuelo</creator><creator>Miguel, Esther</creator><creator>Aznar, Ramón</creator><creator>Tadeo, José L</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Rapid determination of natural and synthetic hormones in biosolids and poultry manure by isotope dilution GC–MS/MS</title><author>Albero, Beatriz ; Sánchez‐Brunete, Consuelo ; Miguel, Esther ; Aznar, Ramón ; Tadeo, José L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5307-cc38f0110e1992666b99c7db59f56eb7921d3016933ef80096f4515a09cf027f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis methods</topic><topic>Analytical chemistry</topic><topic>Applied sciences</topic><topic>Biological Products - analysis</topic><topic>biosolids</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography</topic><topic>Chromatography, Gas</topic><topic>Composting</topic><topic>derivatization</topic><topic>detection limit</topic><topic>Dilution</topic><topic>Drying</topic><topic>estradiol</topic><topic>estrone</topic><topic>Exact sciences and technology</topic><topic>Gas chromatographic methods</topic><topic>Gas chromatography-tandem mass spectrometry</topic><topic>Hormones</topic><topic>Hormones - analysis</topic><topic>Indicator Dilution Techniques</topic><topic>isotope dilution technique</topic><topic>Isotope Labeling</topic><topic>Isotopes</topic><topic>Ketones</topic><topic>land application</topic><topic>Litter</topic><topic>Manure</topic><topic>Manure - analysis</topic><topic>Manures</topic><topic>Mass spectrometry</topic><topic>Pollution</topic><topic>Poultry</topic><topic>Poultry manure</topic><topic>QuEChERS</topic><topic>Sewage sludge</topic><topic>Sex hormones</topic><topic>Sludge</topic><topic>Soil Pollutants - chemistry</topic><topic>synthetic hormones</topic><topic>Tandem Mass Spectrometry</topic><topic>Wastes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Albero, Beatriz</creatorcontrib><creatorcontrib>Sánchez‐Brunete, Consuelo</creatorcontrib><creatorcontrib>Miguel, Esther</creatorcontrib><creatorcontrib>Aznar, Ramón</creatorcontrib><creatorcontrib>Tadeo, José L</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Albero, Beatriz</au><au>Sánchez‐Brunete, Consuelo</au><au>Miguel, Esther</au><au>Aznar, Ramón</au><au>Tadeo, José L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid determination of natural and synthetic hormones in biosolids and poultry manure by isotope dilution GC–MS/MS</atitle><jtitle>Journal of separation science</jtitle><addtitle>J. Sep. Science</addtitle><date>2014-04</date><risdate>2014</risdate><volume>37</volume><issue>7</issue><spage>811</spage><epage>819</epage><pages>811-819</pages><issn>1615-9306</issn><eissn>1615-9314</eissn><abstract>The release of hormones into the environment due to land application of biosolids and manure is a cause of concern for their potential impacts. This paper presents the development of a rapid and sensitive method, based on extraction, for the analysis of 13 hormones in biosolids and poultry manure. A simultaneous derivatization of hydroxyl and ketone groups was carried out for the determination of hormones by GC–MS/MS. The method was validated in three matrices (sewage sludge, manure, and broiler litter). Recoveries from spiked samples at three concentration levels (50, 25, and 10 ng/g) ranged from 76 to 124% with relative SDs ≤ 16%. Method detection limits for the three matrices were in the range of 0.5–3.0 ng/g dry weight. The optimized method was applied to biosolid and poultry manure samples collected in Spain. Only seven of the 13 studied hormones were detected in the different samples. trans‐Androsterone was detected at high levels (up to 3.1 μg/g in biosolid samples). Estrone and estradiol were the two hormones detected at higher levels in layer manure, whereas estrone and 4‐androstene‐3,17‐dione presented the highest levels in broiler litter.</abstract><cop>Weinheim</cop><pub>Blackwell Publishing Ltd</pub><pmid>24812694</pmid><doi>10.1002/jssc.201301037</doi><tpages>9</tpages></addata></record> |
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| subjects | Analysis methods Analytical chemistry Applied sciences Biological Products - analysis biosolids Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Chromatography, Gas Composting derivatization detection limit Dilution Drying estradiol estrone Exact sciences and technology Gas chromatographic methods Gas chromatography-tandem mass spectrometry Hormones Hormones - analysis Indicator Dilution Techniques isotope dilution technique Isotope Labeling Isotopes Ketones land application Litter Manure Manure - analysis Manures Mass spectrometry Pollution Poultry Poultry manure QuEChERS Sewage sludge Sex hormones Sludge Soil Pollutants - chemistry synthetic hormones Tandem Mass Spectrometry Wastes |
| title | Rapid determination of natural and synthetic hormones in biosolids and poultry manure by isotope dilution GC–MS/MS |
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