Factorial Design Studies and Biopharmaceutical Evaluation of Simvastatin Loaded Solid Lipid Nanoparticles for Improving the Oral Bioavailability

Factorial Design Studies and Biopharmaceutical Evaluation of Simvastatin Loaded Solid Lipid Nanoparticles for Improving the Oral Bioavailability

Statins are HMG-CoA reductase inhibitors, which lower the cholesterol level through reversible and competitive inhibition; they are involved in the biosynthesis of cholesterol and other sterols. Simvastatin exhibits poor oral bioavailability (

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Veröffentlicht in:ISRN nanotechnology 2014-01, Vol.2014, p.1-8
Hauptverfasser: Krishnam Raju, Kovoru, Sudhakar, Beeravelli, Murthy, Kolapalli Venkata Ramana
Format: Artikel
Sprache:eng
Schlagworte:
Bioavailability
Drug delivery systems
Drugs
Enzymes
Fatty acids
Homogenization
Homogenizing
Inhibitors
Lipids
Lymphatic system
Metabolism
Nanoparticles
Particle size
Pharmaceutical sciences
Pharmaceuticals
Studies
Surfactants
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Zusammenfassung:Statins are HMG-CoA reductase inhibitors, which lower the cholesterol level through reversible and competitive inhibition; they are involved in the biosynthesis of cholesterol and other sterols. Simvastatin exhibits poor oral bioavailability (
ISSN:2090-6072
2090-6064
2090-6072
DOI:10.1155/2014/951016