Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia

Microglia represent mononuclear phagocytes in the brain and perform immune surveillance, recognizing a number of signaling molecules released from surrounding cells in both healthy and pathological situations. The microglia interact with several damage-associated molecular pattern molecules (DAMPs)...

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Veröffentlicht in:	Molecular and cellular neuroscience 2014-05, Vol.60, p.88-96
Hauptverfasser:	Little, Jonathan P., Simtchouk, Svetlana, Schindler, Stephanie M., Villanueva, Erika B., Gill, Nichole E., Walker, Douglas G., Wolthers, Kirsten R., Klegeris, Andis
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - cytology Brain - metabolism Cell Line, Tumor Cells, Cultured DAMPs DNA-Binding Proteins - metabolism DNA-Binding Proteins - toxicity Extracellular Space - metabolism Glial cells Humans Inflammation - metabolism Interferon-gamma - pharmacology Interleukins - genetics Interleukins - metabolism MAP Kinase Signaling System Microglia - drug effects Microglia - metabolism Mitochondrial proteins Mitochondrial Proteins - metabolism Mitochondrial Proteins - toxicity Monocytes - metabolism Mononuclear phagocytes Neuroinflammation Neurotoxicity Transcription Factors - metabolism Transcription Factors - toxicity
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