Interactions of pyridostigmine with cardiopulmonary systems and their relationships to plasma cholinesterase activity

Three dose levels of pyridostigmine (0.5, 2, and 5 mg/kg) were given iv to dogs anesthetized with sodium pentobarbital. Hemodynamic measurements made were cardiac output, blood pressure, left ventricular dP dT , and heart rate. Pulmonary function data obtained were airway resistance, respiratory rat...

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Veröffentlicht in:	Fundamental and applied toxicology 1989-04, Vol.12 (3), p.432-441
Hauptverfasser:	Caldwell, Robert W., Lowensohn, Howard S., Chryssanthis, Mary A., Nash, Clinton B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - blood Animals Biological and medical sciences Cardiac Output - drug effects Cardiovascular System - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Cholinesterases - blood Dogs Female Heart Rate - drug effects Hemodynamics - drug effects Injections, Intravenous Male Medical sciences Oxygen - blood Pyridostigmine Bromide - toxicity Respiratory Function Tests Respiratory System - drug effects Stroke Volume - drug effects Time Factors Toxicology Various organic compounds
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