Curcumin suppresses cell proliferation through inhibition of the Wnt/β-catenin signaling pathway in medulloblastoma

Recently, the survival rate of medulloblastoma patients has greatly improved; yet, patients undergoing current treatment regimes suffer from serious therapy-related side-effects. The aim of the present study was to investigate the anticancer effects of curcumin on medulloblastoma cells by testing it...

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Veröffentlicht in:	Oncology reports 2014-07, Vol.32 (1), p.173-180
Hauptverfasser:	HE, MISI, LI, YU, ZHANG, LI, LI, LONGJIANG, SHEN, YI, LIN, LING, ZHENG, WEIPING, CHEN, LI, BIAN, XIUWU, NG, HO-KEUNG, TANG, LI
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents - pharmacology Apoptosis - drug effects Cancer Cell cycle Cell growth Cell Line, Tumor Cell Nucleus - metabolism Cell proliferation Cell Proliferation - drug effects Cerebellar Neoplasms - drug therapy Cerebellar Neoplasms - pathology Control curcumin Curcumin - pharmacology Dose-Response Relationship, Drug Drug therapy Flow cytometry Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Health aspects Humans Kinases Low density lipoprotein receptors Medical prognosis Medulloblastoma Medulloblastoma - drug therapy Medulloblastoma - pathology Mutation Penicillin Phosphorylation Proteins Studies Transcription factors Turmeric Wnt signaling pathway Wnt Signaling Pathway - drug effects β-catenin
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