Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells

Fibroblast growth factor receptor 2 (FGFR2) is thought to mediate an important signaling pathway between prostate epithelial cells and stromal cells for maintenance of homeostasis in normal prostate tissue. Abnormalities of FGFR2 have been shown in advanced prostate cancer or prostate cancer cell li...

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Veröffentlicht in:	Oncology reports 2014-07, Vol.32 (1), p.65-70
Hauptverfasser:	SHOJI, KOICHI, TEISHIMA, JUN, HAYASHI, TETSUTARO, OHARA, SHINYA, McKEEHAN, WALLACE L, MATSUBARA, AKIO
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Androgens Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biomarkers Cancer therapies Care and treatment Caspase 3 - metabolism Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects chemosensitivity Chemotherapy Cloning docetaxel Epithelial-Mesenchymal Transition - drug effects fibroblast growth factor receptor 2IIIb Fibroblast growth factor receptors Fibroblasts Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genetic Vectors - genetics Growth factors Humans Laboratories Male Physiological aspects Polyclonal antibodies Prostate cancer Prostatic Neoplasms - pathology Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - pathology Protein Isoforms - genetics Protein Isoforms - metabolism Receptor, Fibroblast Growth Factor, Type 2 - genetics Receptor, Fibroblast Growth Factor, Type 2 - metabolism Stem cells Studies Transfection
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