Altered expression of miR-24, miR-126 and miR-365 does not affect viability of childhood TCF3-rearranged leukemia cells
Among the microRNAs (miRNAs) that control different cellular processes, miR-24, miR-126 and miR-365 were shown to regulate cell cycle progression and apoptosis in various types of tumors. Interestingly, these three miRNAs were downregulated in pediatric TCF3 -rearranged B-cell precursor acute lympho...
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| Veröffentlicht in: | Leukemia 2014-05, Vol.28 (5), p.1008-1014 |
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| creator | Akbari Moqadam, F Boer, J M Lange-Turenhout, E A M Pieters, R den Boer, M L |
| description | Among the microRNAs (miRNAs) that control different cellular processes, miR-24, miR-126 and miR-365 were shown to regulate cell cycle progression and apoptosis in various types of tumors. Interestingly, these three miRNAs were downregulated in pediatric
TCF3
-rearranged B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we showed that individual or combined overexpression of miR-24, miR-126 and miR-365 can neither alter the cell cycle progression nor the amount of apoptosis in 697, KASUMI-2 or MHH-CALL-3
TCF3
-rearranged leukemic cells. We further integrated the miRNA–mRNA expression data of 37 children with BCP-ALL to identify candidate target genes for these three miRNAs. However, the expression levels of selected candidate target genes (
ELL
,
EBF3
and
IRF4
for miR-24,
PITPNC1
for miR-126 and
ZAP-70
for miR-365) did not reduce upon miRNAs overexpression in MHH-CALL-3
TCF3
-rearranged leukemic cells. Although the expression level of
AURKB—
a validated target for miR-24—was reduced upon miR-24 overexpression in hepatocarcinoma HEP-G2 cells, overexpression of miR-24 cannot alter
AURKB
expression levels in MHH-CALL-3
TCF3
-rearranged leukemic cells. Taken together, our data suggest that miRNAs’ function is highly tissue-dependent and that a defined biological target gene or function of one miRNA in a specific tissue cannot be extended as a generalized target/function for that miRNA in all types of cells/tissues. |
| doi_str_mv | 10.1038/leu.2013.308 |
| format | Article |
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TCF3
-rearranged B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we showed that individual or combined overexpression of miR-24, miR-126 and miR-365 can neither alter the cell cycle progression nor the amount of apoptosis in 697, KASUMI-2 or MHH-CALL-3
TCF3
-rearranged leukemic cells. We further integrated the miRNA–mRNA expression data of 37 children with BCP-ALL to identify candidate target genes for these three miRNAs. However, the expression levels of selected candidate target genes (
ELL
,
EBF3
and
IRF4
for miR-24,
PITPNC1
for miR-126 and
ZAP-70
for miR-365) did not reduce upon miRNAs overexpression in MHH-CALL-3
TCF3
-rearranged leukemic cells. Although the expression level of
AURKB—
a validated target for miR-24—was reduced upon miR-24 overexpression in hepatocarcinoma HEP-G2 cells, overexpression of miR-24 cannot alter
AURKB
expression levels in MHH-CALL-3
TCF3
-rearranged leukemic cells. Taken together, our data suggest that miRNAs’ function is highly tissue-dependent and that a defined biological target gene or function of one miRNA in a specific tissue cannot be extended as a generalized target/function for that miRNA in all types of cells/tissues.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/leu.2013.308</identifier><identifier>PMID: 24153013</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/337/384/331 ; 631/67/68 ; 692/699/67/1990/283 ; Acute lymphoblastic leukemia ; Acute lymphocytic leukemia ; Apoptosis ; Base Sequence ; Basic Helix-Loop-Helix Transcription Factors - genetics ; Cancer Research ; Care and treatment ; Cell cycle ; Cell Cycle - genetics ; Cell Line, Tumor ; Childhood ; Children ; Colorectal cancer ; Critical Care Medicine ; Development and progression ; DNA Primers ; Gene expression ; Gene Rearrangement ; Genes ; Genetic aspects ; Health aspects ; Hematology ; Hepatocellular carcinoma ; Humans ; Intensive ; Interferon regulatory factor 4 ; Internal Medicine ; Leukemia ; Liver cancer ; Lymphatic leukemia ; Lymphocytes B ; Medicine ; Medicine & Public Health ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Oncology ; original-article ; Pediatrics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology ; Real-Time Polymerase Chain Reaction ; Target recognition ; Tissues ; Tumors ; ZAP-70 protein</subject><ispartof>Leukemia, 2014-05, Vol.28 (5), p.1008-1014</ispartof><rights>Macmillan Publishers Limited 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2014</rights><rights>Macmillan Publishers Limited 2014.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-847125240bcd7fbd6154a9099d9eee91307f47110751bcdf0ea9e98ef4b83e0c3</citedby><cites>FETCH-LOGICAL-c554t-847125240bcd7fbd6154a9099d9eee91307f47110751bcdf0ea9e98ef4b83e0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/leu.2013.308$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/leu.2013.308$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24153013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akbari Moqadam, F</creatorcontrib><creatorcontrib>Boer, J M</creatorcontrib><creatorcontrib>Lange-Turenhout, E A M</creatorcontrib><creatorcontrib>Pieters, R</creatorcontrib><creatorcontrib>den Boer, M L</creatorcontrib><title>Altered expression of miR-24, miR-126 and miR-365 does not affect viability of childhood TCF3-rearranged leukemia cells</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>Among the microRNAs (miRNAs) that control different cellular processes, miR-24, miR-126 and miR-365 were shown to regulate cell cycle progression and apoptosis in various types of tumors. Interestingly, these three miRNAs were downregulated in pediatric
TCF3
-rearranged B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we showed that individual or combined overexpression of miR-24, miR-126 and miR-365 can neither alter the cell cycle progression nor the amount of apoptosis in 697, KASUMI-2 or MHH-CALL-3
TCF3
-rearranged leukemic cells. We further integrated the miRNA–mRNA expression data of 37 children with BCP-ALL to identify candidate target genes for these three miRNAs. However, the expression levels of selected candidate target genes (
ELL
,
EBF3
and
IRF4
for miR-24,
PITPNC1
for miR-126 and
ZAP-70
for miR-365) did not reduce upon miRNAs overexpression in MHH-CALL-3
TCF3
-rearranged leukemic cells. Although the expression level of
AURKB—
a validated target for miR-24—was reduced upon miR-24 overexpression in hepatocarcinoma HEP-G2 cells, overexpression of miR-24 cannot alter
AURKB
expression levels in MHH-CALL-3
TCF3
-rearranged leukemic cells. Taken together, our data suggest that miRNAs’ function is highly tissue-dependent and that a defined biological target gene or function of one miRNA in a specific tissue cannot be extended as a generalized target/function for that miRNA in all types of cells/tissues.</description><subject>631/337/384/331</subject><subject>631/67/68</subject><subject>692/699/67/1990/283</subject><subject>Acute lymphoblastic leukemia</subject><subject>Acute lymphocytic leukemia</subject><subject>Apoptosis</subject><subject>Base Sequence</subject><subject>Basic Helix-Loop-Helix Transcription Factors - genetics</subject><subject>Cancer Research</subject><subject>Care and treatment</subject><subject>Cell cycle</subject><subject>Cell Cycle - genetics</subject><subject>Cell Line, Tumor</subject><subject>Childhood</subject><subject>Children</subject><subject>Colorectal cancer</subject><subject>Critical Care Medicine</subject><subject>Development and progression</subject><subject>DNA Primers</subject><subject>Gene expression</subject><subject>Gene Rearrangement</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Intensive</subject><subject>Interferon regulatory factor 4</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Liver cancer</subject><subject>Lymphatic leukemia</subject><subject>Lymphocytes B</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Oncology</subject><subject>original-article</subject><subject>Pediatrics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Target recognition</subject><subject>Tissues</subject><subject>Tumors</subject><subject>ZAP-70 protein</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkt9rFDEQxxdR7Fl981kWBPGheybZJJs8HodVoSBIfQ7Z3UkvNbs5k121_72zvaqtFJE8TMh85le-UxTPKVlTUqs3AeY1I7Re10Q9KFaUN7ISQtCHxYoo1VRSM35UPMn5kpDFKR8XR4xTUWPMqvi-CRMk6Ev4sU-Qs49jGV05-E8V4yfXljJZ2rG_vtdSlH2EXI5xKq1z0E3lN29bH_x0tQR2Ox_6XYx9eb49rasENiU7XmAB7PMLDN6WHYSQnxaPnA0Znt3Y4-Lz6dvz7fvq7OO7D9vNWdUJwadK8YYywThpu75xbS-p4FYTrXsNAJrWpHGIUNIIiogjYDVoBY63qgbS1cfF60PefYpfZ8iTGXxeOrAjxDkbKpjWolGa_A_KpCKSMURf_oVexjmNOIhhkouGCyrJvyjMRVEDlOMPdWEDGD-6OCXbLaXNhisla0mUQGp9D4Wnxz_t4gjO4_udgFe3AnZgw7TLMcwTKpzvgicHsEsx5wTO7JMfbLoylJhlwwwqZ5YNM7hhiL-4GWpuB-h_w79WCoHqAGR0ofLp1tT3JfwJxsrUXQ</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Akbari Moqadam, F</creator><creator>Boer, J M</creator><creator>Lange-Turenhout, E A M</creator><creator>Pieters, R</creator><creator>den Boer, M L</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Altered expression of miR-24, miR-126 and miR-365 does not affect viability of childhood TCF3-rearranged leukemia cells</title><author>Akbari Moqadam, F ; Boer, J M ; Lange-Turenhout, E A M ; Pieters, R ; den Boer, M L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-847125240bcd7fbd6154a9099d9eee91307f47110751bcdf0ea9e98ef4b83e0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>631/337/384/331</topic><topic>631/67/68</topic><topic>692/699/67/1990/283</topic><topic>Acute lymphoblastic leukemia</topic><topic>Acute lymphocytic leukemia</topic><topic>Apoptosis</topic><topic>Base Sequence</topic><topic>Basic Helix-Loop-Helix Transcription Factors - genetics</topic><topic>Cancer Research</topic><topic>Care and treatment</topic><topic>Cell cycle</topic><topic>Cell Cycle - genetics</topic><topic>Cell Line, Tumor</topic><topic>Childhood</topic><topic>Children</topic><topic>Colorectal cancer</topic><topic>Critical Care Medicine</topic><topic>Development and progression</topic><topic>DNA Primers</topic><topic>Gene expression</topic><topic>Gene Rearrangement</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Intensive</topic><topic>Interferon regulatory factor 4</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Liver cancer</topic><topic>Lymphatic leukemia</topic><topic>Lymphocytes B</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Oncology</topic><topic>original-article</topic><topic>Pediatrics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Target recognition</topic><topic>Tissues</topic><topic>Tumors</topic><topic>ZAP-70 protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akbari Moqadam, F</creatorcontrib><creatorcontrib>Boer, J M</creatorcontrib><creatorcontrib>Lange-Turenhout, E A M</creatorcontrib><creatorcontrib>Pieters, R</creatorcontrib><creatorcontrib>den Boer, M L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akbari Moqadam, F</au><au>Boer, J M</au><au>Lange-Turenhout, E A M</au><au>Pieters, R</au><au>den Boer, M L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered expression of miR-24, miR-126 and miR-365 does not affect viability of childhood TCF3-rearranged leukemia cells</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>28</volume><issue>5</issue><spage>1008</spage><epage>1014</epage><pages>1008-1014</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><abstract>Among the microRNAs (miRNAs) that control different cellular processes, miR-24, miR-126 and miR-365 were shown to regulate cell cycle progression and apoptosis in various types of tumors. Interestingly, these three miRNAs were downregulated in pediatric
TCF3
-rearranged B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we showed that individual or combined overexpression of miR-24, miR-126 and miR-365 can neither alter the cell cycle progression nor the amount of apoptosis in 697, KASUMI-2 or MHH-CALL-3
TCF3
-rearranged leukemic cells. We further integrated the miRNA–mRNA expression data of 37 children with BCP-ALL to identify candidate target genes for these three miRNAs. However, the expression levels of selected candidate target genes (
ELL
,
EBF3
and
IRF4
for miR-24,
PITPNC1
for miR-126 and
ZAP-70
for miR-365) did not reduce upon miRNAs overexpression in MHH-CALL-3
TCF3
-rearranged leukemic cells. Although the expression level of
AURKB—
a validated target for miR-24—was reduced upon miR-24 overexpression in hepatocarcinoma HEP-G2 cells, overexpression of miR-24 cannot alter
AURKB
expression levels in MHH-CALL-3
TCF3
-rearranged leukemic cells. Taken together, our data suggest that miRNAs’ function is highly tissue-dependent and that a defined biological target gene or function of one miRNA in a specific tissue cannot be extended as a generalized target/function for that miRNA in all types of cells/tissues.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24153013</pmid><doi>10.1038/leu.2013.308</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Leukemia, 2014-05, Vol.28 (5), p.1008-1014 |
| issn | 0887-6924 1476-5551 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 631/337/384/331 631/67/68 692/699/67/1990/283 Acute lymphoblastic leukemia Acute lymphocytic leukemia Apoptosis Base Sequence Basic Helix-Loop-Helix Transcription Factors - genetics Cancer Research Care and treatment Cell cycle Cell Cycle - genetics Cell Line, Tumor Childhood Children Colorectal cancer Critical Care Medicine Development and progression DNA Primers Gene expression Gene Rearrangement Genes Genetic aspects Health aspects Hematology Hepatocellular carcinoma Humans Intensive Interferon regulatory factor 4 Internal Medicine Leukemia Liver cancer Lymphatic leukemia Lymphocytes B Medicine Medicine & Public Health MicroRNA MicroRNAs MicroRNAs - genetics miRNA Oncology original-article Pediatrics Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Real-Time Polymerase Chain Reaction Target recognition Tissues Tumors ZAP-70 protein |
| title | Altered expression of miR-24, miR-126 and miR-365 does not affect viability of childhood TCF3-rearranged leukemia cells |
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