Gosha-jinki-gan reduced oxaliplatin-induced hypersensitivity to cold sensation and its effect would be related to suppression of the expression of TRPM8 and TRPA1 in rats

Peripheral neuropathy is a common side effect of the chemotherapeutic agent oxaliplatin (Oxp), and is associated with hypersensitivity to cold sensation in the acute stage. Recently, gosha-jinki-gan (GJG), a Japanese herbal medicine, was reported to improve Oxp-induced cold hypersensitivity. However...

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Veröffentlicht in:	Anti-cancer drugs 2014-01, Vol.25 (1), p.39-43
Hauptverfasser:	Kato, Yoshinori, Tateai, Yoshikazu, Ohkubo, Misao, Saito, Yuka, Amagai, Syun-ya, Kimura, Yu-suke, Iimura, Naohumi, Okada, Megumi, Matsumoto, Akiko, Mano, Yasunari, Hirosawa, Iori, Ohuchi, Kaori, Tajima, Masataka, Asahi, Mariko, Kotaki, Hajime, Yamada, Harumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - adverse effects Cold Temperature Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Hyperalgesia - chemically induced Hyperalgesia - drug therapy Hyperalgesia - metabolism Male Organoplatinum Compounds - adverse effects Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - metabolism Rats Sensation - drug effects TRPA1 Cation Channel TRPC Cation Channels - genetics TRPC Cation Channels - metabolism TRPM Cation Channels - genetics TRPM Cation Channels - metabolism
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