Failure to downregulate the BAF53a subunit of the SWI/SNF chromatin remodeling complex contributes to the differentiation block in rhabdomyosarcoma

Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children and young adults, is characterized by a partially differentiated myogenic phenotype. We have previously shown that the blocking of tumor growth and resumption of differentiation can be achieved by re-expression of miR-206, a mus...

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Veröffentlicht in:	Oncogene 2014-05, Vol.33 (18), p.2354-2362
Hauptverfasser:	Taulli, R, Foglizzo, V, Morena, D, Coda, D M, Ala, U, Bersani, F, Maestro, N, Ponzetto, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/331 631/45/612/100/102 631/67/1798 692/420/755 Actins - genetics Alveoli Apoptosis Cancer therapies Care and treatment Cell Biology Cell differentiation Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic - genetics Chromatin Chromatin remodeling Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism DNA-Binding Proteins - genetics Down-Regulation Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation, Neoplastic Genetic aspects Genotype & phenotype Human Genetics Humans Internal Medicine Medicine Medicine & Public Health MicroRNAs - metabolism miRNA Muscle Development - genetics Muscle Neoplasms - genetics Muscle Neoplasms - pathology MyoD Protein - metabolism Oncology original-article Phenotypes Physiological aspects Rhabdomyosarcoma Rhabdomyosarcoma - genetics Rhabdomyosarcoma - pathology Risk factors Satellite Cells, Skeletal Muscle - metabolism Satellite Cells, Skeletal Muscle - pathology Soft tissue sarcoma Therapeutic targets Transcription Transcription Factors - metabolism Tumors Young adults
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