Early in vivo MR spectroscopy findings in organophosphate-induced brain damage-potential biomarkers for short-term survival

Organophosphates are highly toxic substances, which cause severe brain damage. The hallmark of the brain injury is major convulsions. The goal of this study was to assess the spatial and temporal MR changes in the brain of paraoxon intoxicated rats. T2‐weighted MRI and 1H‐MR‐spectroscopy were conduc...

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Veröffentlicht in:	Magnetic resonance in medicine 2012-11, Vol.68 (5), p.1390-1398
Hauptverfasser:	Shrot, Shai, Anaby, Debbie, Krivoy, Amir, Makarovsky, Igor, Rosman, Yossi, Bloch-Shilderman, Eugenia, Lazar, Shlomi, Bar-shir, Amnon, Cohen, Yoram
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Brain Injuries - chemically induced Brain Injuries - diagnosis Brain Injuries - metabolism Feasibility Studies imaging Insecticides - toxicity lactate Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Male Neurotoxicity Syndromes - diagnosis Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - metabolism Organophosphate Poisoning - diagnosis Organophosphate Poisoning - metabolism paraoxon Paraoxon - toxicity Prognosis Rats Rats, Sprague-Dawley Reproducibility of Results Risk Assessment - methods Sensitivity and Specificity status-epilepticus Survival Analysis
Online-Zugang:	Volltext
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