Molecular Mechanisms of Inhibition of Influenza by Surfactant Protein D Revealed by Large-Scale Molecular Dynamics Simulation

Surfactant protein D (SP-D), a mammalian C-type lectin, is the primary innate inhibitor of influenza A virus (IAV) in the lung. Interactions of SP-D with highly branched viral N-linked glycans on hemagglutinin (HA), an abundant IAV envelope protein and critical virulence factor, promote viral aggreg...

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Veröffentlicht in:	Biochemistry (Easton) 2013-11, Vol.52 (47), p.8527-8538
Hauptverfasser:	Goh, Boon Chong, Rynkiewicz, Michael J, Cafarella, Tanya R, White, Mitchell R, Hartshorn, Kevan L, Allen, Kimberly, Crouch, Erika C, Calin, Oliviana, Seeberger, Peter H, Schulten, Klaus, Seaton, Barbara A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesiveness Amino Acid Substitution Binding Sites Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - metabolism Humans Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Influenza A virus Influenza A Virus, H3N2 Subtype - chemistry Influenza A Virus, H3N2 Subtype - growth & development Influenza A Virus, H3N2 Subtype - metabolism Microbial Viability Models, Molecular Molecular Dynamics Simulation Mutant Proteins - chemistry Mutant Proteins - metabolism Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Polysaccharides - chemistry Polysaccharides - metabolism Protein Conformation Pulmonary Surfactant-Associated Protein D - chemistry Pulmonary Surfactant-Associated Protein D - genetics Pulmonary Surfactant-Associated Protein D - metabolism Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - chemistry Receptors, Cell Surface - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism
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