Interleukin-24 induces neuroblastoma SH-SY5Y cell differentiation, growth inhibition, and apoptosis by promoting ROS production
Neuroblastoma is among the most aggressive tumors that occur in childhood and infancy. The clinical prognosis of children with advanced-stage neuroblastoma is still poor. Interleukin-24 (IL-24) is emerging as a new cytokine involved in tumor cellular proliferation, differentiation, and apoptosis and...
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| Veröffentlicht in: | Journal of interferon & cytokine research 2013-11, Vol.33 (11), p.709-714 |
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| container_title | Journal of interferon & cytokine research |
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| creator | Li, Yuan Zhang, Hongwei Zhu, Xiaoyu Feng, Dongchuan Gong, Jinchao Han, Tao |
| description | Neuroblastoma is among the most aggressive tumors that occur in childhood and infancy. The clinical prognosis of children with advanced-stage neuroblastoma is still poor. Interleukin-24 (IL-24) is emerging as a new cytokine involved in tumor cellular proliferation, differentiation, and apoptosis and has been widely studied as a tumor inhibitor. However, little is known about this cytokine's role in neuroblastoma. In this study, we investigated the possible effects of IL-24 on inducing neuroblastoma cell differentiation, growth inhibition, and apoptosis in vitro. Our data show that IL-24 promotes neuroblastoma SH-SY5Y cell differentiation, growth inhibition, and apoptosis. Furthermore, we found that the differentiation- and apoptosis-inducing action of IL-24 depends on the accumulation of reactive oxygen species (ROS). These results suggest that IL-24 can induce neuroblastoma cell differentiation and apoptosis and may be a potential therapeutic agent for neuroblastoma. |
| doi_str_mv | 10.1089/jir.2013.0004 |
| format | Article |
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The clinical prognosis of children with advanced-stage neuroblastoma is still poor. Interleukin-24 (IL-24) is emerging as a new cytokine involved in tumor cellular proliferation, differentiation, and apoptosis and has been widely studied as a tumor inhibitor. However, little is known about this cytokine's role in neuroblastoma. In this study, we investigated the possible effects of IL-24 on inducing neuroblastoma cell differentiation, growth inhibition, and apoptosis in vitro. Our data show that IL-24 promotes neuroblastoma SH-SY5Y cell differentiation, growth inhibition, and apoptosis. Furthermore, we found that the differentiation- and apoptosis-inducing action of IL-24 depends on the accumulation of reactive oxygen species (ROS). These results suggest that IL-24 can induce neuroblastoma cell differentiation and apoptosis and may be a potential therapeutic agent for neuroblastoma.</description><identifier>ISSN: 1079-9907</identifier><identifier>EISSN: 1557-7465</identifier><identifier>DOI: 10.1089/jir.2013.0004</identifier><identifier>PMID: 23692552</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Apoptosis ; Cell Differentiation ; Cell Proliferation ; Cell Survival ; Humans ; Interleukins - genetics ; Interleukins - metabolism ; Neuroblastoma - metabolism ; Neuroblastoma - pathology ; Reactive Oxygen Species - metabolism ; Tumor Cells, Cultured</subject><ispartof>Journal of interferon & cytokine research, 2013-11, Vol.33 (11), p.709-714</ispartof><rights>(©) Copyright 2013, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-6d896b8f2e84db8d81641b02a13c8ad8de3991c25b0c0c09873ef78fd62c7863</citedby><cites>FETCH-LOGICAL-c354t-6d896b8f2e84db8d81641b02a13c8ad8de3991c25b0c0c09873ef78fd62c7863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23692552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yuan</creatorcontrib><creatorcontrib>Zhang, Hongwei</creatorcontrib><creatorcontrib>Zhu, Xiaoyu</creatorcontrib><creatorcontrib>Feng, Dongchuan</creatorcontrib><creatorcontrib>Gong, Jinchao</creatorcontrib><creatorcontrib>Han, Tao</creatorcontrib><title>Interleukin-24 induces neuroblastoma SH-SY5Y cell differentiation, growth inhibition, and apoptosis by promoting ROS production</title><title>Journal of interferon & cytokine research</title><addtitle>J Interferon Cytokine Res</addtitle><description>Neuroblastoma is among the most aggressive tumors that occur in childhood and infancy. 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These results suggest that IL-24 can induce neuroblastoma cell differentiation and apoptosis and may be a potential therapeutic agent for neuroblastoma.</description><subject>Apoptosis</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Cell Survival</subject><subject>Humans</subject><subject>Interleukins - genetics</subject><subject>Interleukins - metabolism</subject><subject>Neuroblastoma - metabolism</subject><subject>Neuroblastoma - pathology</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Tumor Cells, Cultured</subject><issn>1079-9907</issn><issn>1557-7465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0ctLHTEUB-BQlPpol92WgJsuOrd5P5YibRUEwevG1ZCZZDS3M8k1ySCu-q-b4aoLN5JFHnw5h8MPgG8YrTBS-tfGpxVBmK4QQuwTOMScy0YywffqGUndaI3kATjKeVOFUER_BgeECk04J4fg_0UoLo1u_udDQxj0wc69yzC4OcVuNLnEycD1ebO-5bewd-MIrR8Gl1wo3hQfw094l-Jjua9f733nd08mWGi2cVti9hl2T3Cb4hSLD3fw-mq93GqbhX4B-4MZs_v6sh-Dmz-_b87Om8urvxdnp5dNTzkrjbBKi04NxClmO2UVFgx3iBhMe2Wsso5qjXvCO9TXpZWkbpBqsIL0Ugl6DH7sytbOD7PLpZ18XqYxwcU5t5gTrSnTiH5MGZNMS0xJpSfv6CbOKdQ5FiUqRExV1exUn2LOyQ3tNvnJpKcWo3bJsK0ZtkuG7ZJh9d9fqs7d5Oybfg2NPgMIt5fS</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Li, Yuan</creator><creator>Zhang, Hongwei</creator><creator>Zhu, Xiaoyu</creator><creator>Feng, Dongchuan</creator><creator>Gong, Jinchao</creator><creator>Han, Tao</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>Interleukin-24 induces neuroblastoma SH-SY5Y cell differentiation, growth inhibition, and apoptosis by promoting ROS production</title><author>Li, Yuan ; 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These results suggest that IL-24 can induce neuroblastoma cell differentiation and apoptosis and may be a potential therapeutic agent for neuroblastoma.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>23692552</pmid><doi>10.1089/jir.2013.0004</doi><tpages>6</tpages></addata></record> |
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| subjects | Apoptosis Cell Differentiation Cell Proliferation Cell Survival Humans Interleukins - genetics Interleukins - metabolism Neuroblastoma - metabolism Neuroblastoma - pathology Reactive Oxygen Species - metabolism Tumor Cells, Cultured |
| title | Interleukin-24 induces neuroblastoma SH-SY5Y cell differentiation, growth inhibition, and apoptosis by promoting ROS production |
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