Identification of REST-Regulated Genes and Pathways Using a REST-Targeted Antisense Approach

The repressor element-1 silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is one of the first negative-acting transcriptional regulators implicated in vertebrate development thought to regulate hundreds of neuron-specific genes. However, its function in the adult system r...

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Veröffentlicht in:	Nucleic acid therapeutics 2013-12, Vol.23 (6), p.389-400
Hauptverfasser:	Sedaghat, Yalda, Bui, Huynh-Hoa, Mazur, Curt, Monia, Brett P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Gene Expression Regulation Gene Knockdown Techniques Gene Regulatory Networks Genes Liver - metabolism Male Mice Mice, Inbred BALB C Neurodegeneration Neurons Oligonucleotide Array Sequence Analysis Oligonucleotides, Antisense - genetics Original Research Articles Regulatory Sequences, Nucleic Acid Repressor Proteins - genetics Repressor Proteins - metabolism Transcriptome Vertebrates
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