Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells

Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in childhood. Despite the advances in treatment, about 20% of patients relapse and/or die, indicating the need for different therapies for this group. Zebularine (ZB) is a potent DNA methyltransferase (DNMT) inhibitor and h...

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Veröffentlicht in:	Anti-cancer drugs 2014-01, Vol.25 (1), p.72-81
Hauptverfasser:	Andrade, Augusto F, Borges, Kleiton S, Castro-Gamero, Angel M, Silveira, Vanessa S, Suazo, Veridiana K, Oliveira, Jaqueline C, Moreno, Daniel A, de Paula Queiroz, Rosane G, Scrideli, Carlos A, Tone, Luiz G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Line, Tumor Cytidine - analogs & derivatives Cytidine - pharmacology DNA Modification Methylases - antagonists & inhibitors Drug Antagonism Drug Resistance, Neoplasm Drug Synergism Humans Methotrexate - pharmacology Methylation Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Vincristine - pharmacology
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