Biochemical Recurrence–free Survival After Robotic-assisted Laparoscopic vs Open Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer
Objective To compare biochemical recurrence (BCR)–free survival and predictors of BCR in intermediate-risk (IR) and high-risk (HR) patients undergoing robotic-assisted laparoscopic prostatectomy (RALP) vs open radical prostatectomy (ORP). Materials and Methods We conducted a retrospective study on 1...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 2014-06, Vol.83 (6), p.1309-1315 |
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| creator | Ritch, Chad R You, Chaochen May, Alexandra T Herrell, S. Duke Clark, Peter E Penson, David F Chang, Sam S Cookson, Michael S Smith, Joseph A Barocas, Daniel A |
| description | Objective To compare biochemical recurrence (BCR)–free survival and predictors of BCR in intermediate-risk (IR) and high-risk (HR) patients undergoing robotic-assisted laparoscopic prostatectomy (RALP) vs open radical prostatectomy (ORP). Materials and Methods We conducted a retrospective study on 1336 men with D'Amico IR or HR prostate cancer who underwent RALP or ORP between 2003 and 2009. Exclusion criteria were use of neoadjuvant therapy, |
| doi_str_mv | 10.1016/j.urology.2014.02.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1529850379</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0090429514001824</els_id><sourcerecordid>1529850379</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-3f6fb3a85d078033f7d5e817efe7d623f1e63dd2a20a5b5d83694deef3227bb63</originalsourceid><addsrcrecordid>eNqFks1uEzEQx1cIRNPCI4B8QeKywR_r_biASlRopUhFKZwtrz1unW7Wwd6NlBvvwIXn40mYJaFIXJAs2fL8Zjz-_yfLXjA6Z5SVb9bzMYYu3O7nnLJiTjku8SibMcmrvGka-TibUdrQvOCNPMlOU1pTSsuyrJ5mJ7yoCjzKWfbjvQ_mDjbe6I6swIwxQm_g57fvLgKQmzHu_A5D526ASFahDYM3uU7JpwEsWeqtjiGZsPWG7BK53kJPVtr-LvcJI4MewAxhsycuRHLVY5UNWI-3OdG9JZf-9i6PPt0_0GShsYH4LHvidJfg-XE_y758uPi8uMyX1x-vFufL3EhWDrlwpWuFrqWlVU2FcJWVULMKHFS25MIxKIW1XHOqZSttLcqmsABOcF61bSnOsteHutsYvo6QBrXxyUDX6R7CmBTq2dSSiqpBVB5Qg62mCE5to9_ouFeMqskUtVZHU9RkiqIcl8C8l8cnxhY__5D1xwUEXh0BnVA4F1EBn_5ytaxkwShy7w4coCA7D1El4ye7rI-osrLB_7eVt_9UMJ3vJ7fuYQ9pHcbYo9qKqYQJ6maaoGmAWEEpq3khfgEYC8al</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1529850379</pqid></control><display><type>article</type><title>Biochemical Recurrence–free Survival After Robotic-assisted Laparoscopic vs Open Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Ritch, Chad R ; You, Chaochen ; May, Alexandra T ; Herrell, S. Duke ; Clark, Peter E ; Penson, David F ; Chang, Sam S ; Cookson, Michael S ; Smith, Joseph A ; Barocas, Daniel A</creator><creatorcontrib>Ritch, Chad R ; You, Chaochen ; May, Alexandra T ; Herrell, S. Duke ; Clark, Peter E ; Penson, David F ; Chang, Sam S ; Cookson, Michael S ; Smith, Joseph A ; Barocas, Daniel A</creatorcontrib><description>Objective To compare biochemical recurrence (BCR)–free survival and predictors of BCR in intermediate-risk (IR) and high-risk (HR) patients undergoing robotic-assisted laparoscopic prostatectomy (RALP) vs open radical prostatectomy (ORP). Materials and Methods We conducted a retrospective study on 1336 men with D'Amico IR or HR prostate cancer who underwent RALP or ORP between 2003 and 2009. Exclusion criteria were use of neoadjuvant therapy, <6 months of follow-up, and insufficient clinicopathologic data. We compared demographic, clinical, and pathologic variables between groups. Kaplan-Meier analysis was performed to compare the 5-year BCR-free survival between groups. Multivariate models were developed to determine whether surgical approach influences BCR. Results A total of 979 IR and HR patients (237 ORP and 742 RALP patients) met inclusion criteria. Median follow-up was shorter for RALP (43 vs 63 months; P <.001). ORP patients had a higher median prostate-specific antigen level (7.9 vs 6.7 ng/mL; P <.002), significantly more Gleason sum 8-10 tumors, and more adverse pathologic features overall. There was no difference in positive surgical margins between groups. Pathologic features including extraprostatic extension, seminal vesicle involvement, lymph node involvement, pathologic Gleason sum, and positive surgical margin were significant independent predictors of BCR in multivariate analysis. Surgical approach (RALP vs ORP) did not predict BCR when controlling for other known predictors of BCR. Conclusion Among IR and HR prostate cancer patients, the oncologic outcomes are similar between RALP and ORP. Not surprisingly, adverse pathologic features are harbingers of BCR.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/j.urology.2014.02.023</identifier><identifier>PMID: 24746665</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cohort Studies ; Disease-Free Survival ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Kaplan-Meier Estimate ; Laparoscopy - methods ; Laparoscopy - mortality ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Nephrology. Urinary tract diseases ; Postoperative Complications - mortality ; Postoperative Complications - physiopathology ; Postoperative Complications - therapy ; Predictive Value of Tests ; Proportional Hazards Models ; Prostatectomy - methods ; Prostatectomy - mortality ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Retrospective Studies ; Risk Assessment ; Robotics - methods ; Time Factors ; Treatment Outcome ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland ; Urologic Surgical Procedures, Male - methods ; Urology</subject><ispartof>Urology (Ridgewood, N.J.), 2014-06, Vol.83 (6), p.1309-1315</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-3f6fb3a85d078033f7d5e817efe7d623f1e63dd2a20a5b5d83694deef3227bb63</citedby><cites>FETCH-LOGICAL-c516t-3f6fb3a85d078033f7d5e817efe7d623f1e63dd2a20a5b5d83694deef3227bb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0090429514001824$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28575410$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24746665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ritch, Chad R</creatorcontrib><creatorcontrib>You, Chaochen</creatorcontrib><creatorcontrib>May, Alexandra T</creatorcontrib><creatorcontrib>Herrell, S. Duke</creatorcontrib><creatorcontrib>Clark, Peter E</creatorcontrib><creatorcontrib>Penson, David F</creatorcontrib><creatorcontrib>Chang, Sam S</creatorcontrib><creatorcontrib>Cookson, Michael S</creatorcontrib><creatorcontrib>Smith, Joseph A</creatorcontrib><creatorcontrib>Barocas, Daniel A</creatorcontrib><title>Biochemical Recurrence–free Survival After Robotic-assisted Laparoscopic vs Open Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>Objective To compare biochemical recurrence (BCR)–free survival and predictors of BCR in intermediate-risk (IR) and high-risk (HR) patients undergoing robotic-assisted laparoscopic prostatectomy (RALP) vs open radical prostatectomy (ORP). Materials and Methods We conducted a retrospective study on 1336 men with D'Amico IR or HR prostate cancer who underwent RALP or ORP between 2003 and 2009. Exclusion criteria were use of neoadjuvant therapy, <6 months of follow-up, and insufficient clinicopathologic data. We compared demographic, clinical, and pathologic variables between groups. Kaplan-Meier analysis was performed to compare the 5-year BCR-free survival between groups. Multivariate models were developed to determine whether surgical approach influences BCR. Results A total of 979 IR and HR patients (237 ORP and 742 RALP patients) met inclusion criteria. Median follow-up was shorter for RALP (43 vs 63 months; P <.001). ORP patients had a higher median prostate-specific antigen level (7.9 vs 6.7 ng/mL; P <.002), significantly more Gleason sum 8-10 tumors, and more adverse pathologic features overall. There was no difference in positive surgical margins between groups. Pathologic features including extraprostatic extension, seminal vesicle involvement, lymph node involvement, pathologic Gleason sum, and positive surgical margin were significant independent predictors of BCR in multivariate analysis. Surgical approach (RALP vs ORP) did not predict BCR when controlling for other known predictors of BCR. Conclusion Among IR and HR prostate cancer patients, the oncologic outcomes are similar between RALP and ORP. Not surprisingly, adverse pathologic features are harbingers of BCR.</description><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Disease-Free Survival</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Laparoscopy - methods</subject><subject>Laparoscopy - mortality</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Postoperative Complications - mortality</subject><subject>Postoperative Complications - physiopathology</subject><subject>Postoperative Complications - therapy</subject><subject>Predictive Value of Tests</subject><subject>Proportional Hazards Models</subject><subject>Prostatectomy - methods</subject><subject>Prostatectomy - mortality</subject><subject>Prostatic Neoplasms - mortality</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Robotics - methods</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><subject>Urologic Surgical Procedures, Male - methods</subject><subject>Urology</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1uEzEQx1cIRNPCI4B8QeKywR_r_biASlRopUhFKZwtrz1unW7Wwd6NlBvvwIXn40mYJaFIXJAs2fL8Zjz-_yfLXjA6Z5SVb9bzMYYu3O7nnLJiTjku8SibMcmrvGka-TibUdrQvOCNPMlOU1pTSsuyrJ5mJ7yoCjzKWfbjvQ_mDjbe6I6swIwxQm_g57fvLgKQmzHu_A5D526ASFahDYM3uU7JpwEsWeqtjiGZsPWG7BK53kJPVtr-LvcJI4MewAxhsycuRHLVY5UNWI-3OdG9JZf-9i6PPt0_0GShsYH4LHvidJfg-XE_y758uPi8uMyX1x-vFufL3EhWDrlwpWuFrqWlVU2FcJWVULMKHFS25MIxKIW1XHOqZSttLcqmsABOcF61bSnOsteHutsYvo6QBrXxyUDX6R7CmBTq2dSSiqpBVB5Qg62mCE5to9_ouFeMqskUtVZHU9RkiqIcl8C8l8cnxhY__5D1xwUEXh0BnVA4F1EBn_5ytaxkwShy7w4coCA7D1El4ye7rI-osrLB_7eVt_9UMJ3vJ7fuYQ9pHcbYo9qKqYQJ6maaoGmAWEEpq3khfgEYC8al</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Ritch, Chad R</creator><creator>You, Chaochen</creator><creator>May, Alexandra T</creator><creator>Herrell, S. Duke</creator><creator>Clark, Peter E</creator><creator>Penson, David F</creator><creator>Chang, Sam S</creator><creator>Cookson, Michael S</creator><creator>Smith, Joseph A</creator><creator>Barocas, Daniel A</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Biochemical Recurrence–free Survival After Robotic-assisted Laparoscopic vs Open Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer</title><author>Ritch, Chad R ; You, Chaochen ; May, Alexandra T ; Herrell, S. Duke ; Clark, Peter E ; Penson, David F ; Chang, Sam S ; Cookson, Michael S ; Smith, Joseph A ; Barocas, Daniel A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-3f6fb3a85d078033f7d5e817efe7d623f1e63dd2a20a5b5d83694deef3227bb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Disease-Free Survival</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Laparoscopy - methods</topic><topic>Laparoscopy - mortality</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Postoperative Complications - mortality</topic><topic>Postoperative Complications - physiopathology</topic><topic>Postoperative Complications - therapy</topic><topic>Predictive Value of Tests</topic><topic>Proportional Hazards Models</topic><topic>Prostatectomy - methods</topic><topic>Prostatectomy - mortality</topic><topic>Prostatic Neoplasms - mortality</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Robotics - methods</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><topic>Urologic Surgical Procedures, Male - methods</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ritch, Chad R</creatorcontrib><creatorcontrib>You, Chaochen</creatorcontrib><creatorcontrib>May, Alexandra T</creatorcontrib><creatorcontrib>Herrell, S. Duke</creatorcontrib><creatorcontrib>Clark, Peter E</creatorcontrib><creatorcontrib>Penson, David F</creatorcontrib><creatorcontrib>Chang, Sam S</creatorcontrib><creatorcontrib>Cookson, Michael S</creatorcontrib><creatorcontrib>Smith, Joseph A</creatorcontrib><creatorcontrib>Barocas, Daniel A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ritch, Chad R</au><au>You, Chaochen</au><au>May, Alexandra T</au><au>Herrell, S. Duke</au><au>Clark, Peter E</au><au>Penson, David F</au><au>Chang, Sam S</au><au>Cookson, Michael S</au><au>Smith, Joseph A</au><au>Barocas, Daniel A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biochemical Recurrence–free Survival After Robotic-assisted Laparoscopic vs Open Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>83</volume><issue>6</issue><spage>1309</spage><epage>1315</epage><pages>1309-1315</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><coden>URGYAZ</coden><abstract>Objective To compare biochemical recurrence (BCR)–free survival and predictors of BCR in intermediate-risk (IR) and high-risk (HR) patients undergoing robotic-assisted laparoscopic prostatectomy (RALP) vs open radical prostatectomy (ORP). Materials and Methods We conducted a retrospective study on 1336 men with D'Amico IR or HR prostate cancer who underwent RALP or ORP between 2003 and 2009. Exclusion criteria were use of neoadjuvant therapy, <6 months of follow-up, and insufficient clinicopathologic data. We compared demographic, clinical, and pathologic variables between groups. Kaplan-Meier analysis was performed to compare the 5-year BCR-free survival between groups. Multivariate models were developed to determine whether surgical approach influences BCR. Results A total of 979 IR and HR patients (237 ORP and 742 RALP patients) met inclusion criteria. Median follow-up was shorter for RALP (43 vs 63 months; P <.001). ORP patients had a higher median prostate-specific antigen level (7.9 vs 6.7 ng/mL; P <.002), significantly more Gleason sum 8-10 tumors, and more adverse pathologic features overall. There was no difference in positive surgical margins between groups. Pathologic features including extraprostatic extension, seminal vesicle involvement, lymph node involvement, pathologic Gleason sum, and positive surgical margin were significant independent predictors of BCR in multivariate analysis. Surgical approach (RALP vs ORP) did not predict BCR when controlling for other known predictors of BCR. Conclusion Among IR and HR prostate cancer patients, the oncologic outcomes are similar between RALP and ORP. Not surprisingly, adverse pathologic features are harbingers of BCR.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>24746665</pmid><doi>10.1016/j.urology.2014.02.023</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological and medical sciences Cohort Studies Disease-Free Survival Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Kaplan-Meier Estimate Laparoscopy - methods Laparoscopy - mortality Male Male genital diseases Medical sciences Middle Aged Multivariate Analysis Neoplasm Invasiveness - pathology Neoplasm Staging Nephrology. Urinary tract diseases Postoperative Complications - mortality Postoperative Complications - physiopathology Postoperative Complications - therapy Predictive Value of Tests Proportional Hazards Models Prostatectomy - methods Prostatectomy - mortality Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Retrospective Studies Risk Assessment Robotics - methods Time Factors Treatment Outcome Tumors Tumors of the urinary system Urinary tract. Prostate gland Urologic Surgical Procedures, Male - methods Urology |
| title | Biochemical Recurrence–free Survival After Robotic-assisted Laparoscopic vs Open Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer |
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