An improved method for the characterization of supersaturation and precipitation of poorly soluble drugs using pulsatile microdialysis (PMD)

[Display omitted] In current pharmaceutical drug discovery, most candidates are poorly soluble in water, which can result in poor bioavailability. To overcome this problem, formulations that create supersaturation of the drug are a well-studied alternative. Characterizing the dissolution from these...

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Veröffentlicht in:International journal of pharmaceutics 2014-07, Vol.468 (1-2), p.64-74
Hauptverfasser: Shah, Kosha B., Patel, Piyush G., Khairuzzaman, Akm, Bellantone, Robert A.
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Sprache:eng
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