Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia
Decreases in astrocyte density and in glial fibrillary acid protein (GFAP) mRNA in the anterior cingulate cortex have been reported changed in mood and affective disorders. Our study examines the relative density and frequency of fibrillary and gemistocytic astrocytes in the white matter of the subg...
Gespeichert in:
| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 2014-06, Vol.264 (4), p.357-362 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 362 |
|---|---|
| container_issue | 4 |
| container_start_page | 357 |
| container_title | European archives of psychiatry and clinical neuroscience |
| container_volume | 264 |
| creator | Williams, Matthew Pearce, Ronald K. B. Hirsch, Steven R. Ansorge, Olaf Thom, Maria Maier, Michael |
| description | Decreases in astrocyte density and in glial fibrillary acid protein (GFAP) mRNA in the anterior cingulate cortex have been reported changed in mood and affective disorders. Our study examines the relative density and frequency of fibrillary and gemistocytic astrocytes in the white matter of the subgenual cingulate cortex in 11 schizophrenia, 16 bipolar disorder, 20 major depression and 20 normal control cases. Serial coronal sections were stained with H&E for anatomical guidance and GFAP immunohistochemistry for astrocyte identification. Astrocyte density was measured using systematic anatomical distinctions and randomised counting methods previously reported. Astrocytes were classified as fibrillary or gemistocytic based on staining and morphometric criteria and were measured in the crown and base of the gyral white matter. Fibrillary astrocytes were decreased in the base of the cingulate white matter in schizophrenia (
p
= 0.046), with no change in the density of gemistocytic astrocytes. There was no change in density of gemistocytic astrocytes. This suggests that the previously reported decrease in astrocytes in schizophrenia in the subgenual cingulate is accounted for only by a change in fibrillary astrocytes. With recent findings suggesting fibrillary astrocytes regulate synaptic glutamate this morphological change may relate to disregulation of function of the subgenual cingulate cortex. |
| doi_str_mv | 10.1007/s00406-013-0482-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1529842249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1529842249</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-5316c4b88949ddc7894177474d771eff2e7608e9c0ac60a956306a2d75813d1f3</originalsourceid><addsrcrecordid>eNp1kD1PwzAQhi0EoqXwA1hQJBaWwNm-xPGIKr4kpC4wW65zaVOlSbGTofx6XLUghMR0wz332u_D2CWHWw6g7gIAQp4ClylgIVI8YmOOUqYFan7MxqARUi4ljthZCCsA4JmAUzYSKBVqmY_Z7LGe-7pprN8mNvS-c9ueQmI9JSU5TzZQmdRt0i8pCcN8Qe1gm8TV7WJobE-7VXDL-rPbLD21tT1nJ5VtAl0c5oS9Pz68TZ_T19nTy_T-NXWIok8zyXOH86LQqMvSqTi5UqiwVIpTVQlSORSkHViXg9VZLiG3olRZwWXJKzlhN_vcje8-Bgq9WdfBUSzSUjcEE4vqAoWILSfs-g-66gbfxt9FSoLgmZZZpPiecr4LwVNlNr5eRy2Gg9nZNnvbJto2O9sG483VIXmYr6n8ufjWGwGxB0JctQvyv57-N_UL1IaI1w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1530215935</pqid></control><display><type>article</type><title>Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Williams, Matthew ; Pearce, Ronald K. B. ; Hirsch, Steven R. ; Ansorge, Olaf ; Thom, Maria ; Maier, Michael</creator><creatorcontrib>Williams, Matthew ; Pearce, Ronald K. B. ; Hirsch, Steven R. ; Ansorge, Olaf ; Thom, Maria ; Maier, Michael</creatorcontrib><description>Decreases in astrocyte density and in glial fibrillary acid protein (GFAP) mRNA in the anterior cingulate cortex have been reported changed in mood and affective disorders. Our study examines the relative density and frequency of fibrillary and gemistocytic astrocytes in the white matter of the subgenual cingulate cortex in 11 schizophrenia, 16 bipolar disorder, 20 major depression and 20 normal control cases. Serial coronal sections were stained with H&E for anatomical guidance and GFAP immunohistochemistry for astrocyte identification. Astrocyte density was measured using systematic anatomical distinctions and randomised counting methods previously reported. Astrocytes were classified as fibrillary or gemistocytic based on staining and morphometric criteria and were measured in the crown and base of the gyral white matter. Fibrillary astrocytes were decreased in the base of the cingulate white matter in schizophrenia (
p
= 0.046), with no change in the density of gemistocytic astrocytes. There was no change in density of gemistocytic astrocytes. This suggests that the previously reported decrease in astrocytes in schizophrenia in the subgenual cingulate is accounted for only by a change in fibrillary astrocytes. With recent findings suggesting fibrillary astrocytes regulate synaptic glutamate this morphological change may relate to disregulation of function of the subgenual cingulate cortex.</description><identifier>ISSN: 0940-1334</identifier><identifier>EISSN: 1433-8491</identifier><identifier>DOI: 10.1007/s00406-013-0482-4</identifier><identifier>PMID: 24374936</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Astrocytes - metabolism ; Cell Count ; Female ; Glial Fibrillary Acidic Protein - metabolism ; Gyrus Cinguli - metabolism ; Gyrus Cinguli - pathology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mood Disorders - pathology ; Neurosciences ; Psychiatry ; Schizophrenia - pathology ; Short Communication ; Young Adult</subject><ispartof>European archives of psychiatry and clinical neuroscience, 2014-06, Vol.264 (4), p.357-362</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-5316c4b88949ddc7894177474d771eff2e7608e9c0ac60a956306a2d75813d1f3</citedby><cites>FETCH-LOGICAL-c442t-5316c4b88949ddc7894177474d771eff2e7608e9c0ac60a956306a2d75813d1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00406-013-0482-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00406-013-0482-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24374936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Matthew</creatorcontrib><creatorcontrib>Pearce, Ronald K. B.</creatorcontrib><creatorcontrib>Hirsch, Steven R.</creatorcontrib><creatorcontrib>Ansorge, Olaf</creatorcontrib><creatorcontrib>Thom, Maria</creatorcontrib><creatorcontrib>Maier, Michael</creatorcontrib><title>Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia</title><title>European archives of psychiatry and clinical neuroscience</title><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><description>Decreases in astrocyte density and in glial fibrillary acid protein (GFAP) mRNA in the anterior cingulate cortex have been reported changed in mood and affective disorders. Our study examines the relative density and frequency of fibrillary and gemistocytic astrocytes in the white matter of the subgenual cingulate cortex in 11 schizophrenia, 16 bipolar disorder, 20 major depression and 20 normal control cases. Serial coronal sections were stained with H&E for anatomical guidance and GFAP immunohistochemistry for astrocyte identification. Astrocyte density was measured using systematic anatomical distinctions and randomised counting methods previously reported. Astrocytes were classified as fibrillary or gemistocytic based on staining and morphometric criteria and were measured in the crown and base of the gyral white matter. Fibrillary astrocytes were decreased in the base of the cingulate white matter in schizophrenia (
p
= 0.046), with no change in the density of gemistocytic astrocytes. There was no change in density of gemistocytic astrocytes. This suggests that the previously reported decrease in astrocytes in schizophrenia in the subgenual cingulate is accounted for only by a change in fibrillary astrocytes. With recent findings suggesting fibrillary astrocytes regulate synaptic glutamate this morphological change may relate to disregulation of function of the subgenual cingulate cortex.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Astrocytes - metabolism</subject><subject>Cell Count</subject><subject>Female</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Gyrus Cinguli - metabolism</subject><subject>Gyrus Cinguli - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mood Disorders - pathology</subject><subject>Neurosciences</subject><subject>Psychiatry</subject><subject>Schizophrenia - pathology</subject><subject>Short Communication</subject><subject>Young Adult</subject><issn>0940-1334</issn><issn>1433-8491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kD1PwzAQhi0EoqXwA1hQJBaWwNm-xPGIKr4kpC4wW65zaVOlSbGTofx6XLUghMR0wz332u_D2CWHWw6g7gIAQp4ClylgIVI8YmOOUqYFan7MxqARUi4ljthZCCsA4JmAUzYSKBVqmY_Z7LGe-7pprN8mNvS-c9ueQmI9JSU5TzZQmdRt0i8pCcN8Qe1gm8TV7WJobE-7VXDL-rPbLD21tT1nJ5VtAl0c5oS9Pz68TZ_T19nTy_T-NXWIok8zyXOH86LQqMvSqTi5UqiwVIpTVQlSORSkHViXg9VZLiG3olRZwWXJKzlhN_vcje8-Bgq9WdfBUSzSUjcEE4vqAoWILSfs-g-66gbfxt9FSoLgmZZZpPiecr4LwVNlNr5eRy2Gg9nZNnvbJto2O9sG483VIXmYr6n8ufjWGwGxB0JctQvyv57-N_UL1IaI1w</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Williams, Matthew</creator><creator>Pearce, Ronald K. B.</creator><creator>Hirsch, Steven R.</creator><creator>Ansorge, Olaf</creator><creator>Thom, Maria</creator><creator>Maier, Michael</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia</title><author>Williams, Matthew ; Pearce, Ronald K. B. ; Hirsch, Steven R. ; Ansorge, Olaf ; Thom, Maria ; Maier, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-5316c4b88949ddc7894177474d771eff2e7608e9c0ac60a956306a2d75813d1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Astrocytes - metabolism</topic><topic>Cell Count</topic><topic>Female</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>Gyrus Cinguli - metabolism</topic><topic>Gyrus Cinguli - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mood Disorders - pathology</topic><topic>Neurosciences</topic><topic>Psychiatry</topic><topic>Schizophrenia - pathology</topic><topic>Short Communication</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Matthew</creatorcontrib><creatorcontrib>Pearce, Ronald K. B.</creatorcontrib><creatorcontrib>Hirsch, Steven R.</creatorcontrib><creatorcontrib>Ansorge, Olaf</creatorcontrib><creatorcontrib>Thom, Maria</creatorcontrib><creatorcontrib>Maier, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of psychiatry and clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Matthew</au><au>Pearce, Ronald K. B.</au><au>Hirsch, Steven R.</au><au>Ansorge, Olaf</au><au>Thom, Maria</au><au>Maier, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia</atitle><jtitle>European archives of psychiatry and clinical neuroscience</jtitle><stitle>Eur Arch Psychiatry Clin Neurosci</stitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>264</volume><issue>4</issue><spage>357</spage><epage>362</epage><pages>357-362</pages><issn>0940-1334</issn><eissn>1433-8491</eissn><abstract>Decreases in astrocyte density and in glial fibrillary acid protein (GFAP) mRNA in the anterior cingulate cortex have been reported changed in mood and affective disorders. Our study examines the relative density and frequency of fibrillary and gemistocytic astrocytes in the white matter of the subgenual cingulate cortex in 11 schizophrenia, 16 bipolar disorder, 20 major depression and 20 normal control cases. Serial coronal sections were stained with H&E for anatomical guidance and GFAP immunohistochemistry for astrocyte identification. Astrocyte density was measured using systematic anatomical distinctions and randomised counting methods previously reported. Astrocytes were classified as fibrillary or gemistocytic based on staining and morphometric criteria and were measured in the crown and base of the gyral white matter. Fibrillary astrocytes were decreased in the base of the cingulate white matter in schizophrenia (
p
= 0.046), with no change in the density of gemistocytic astrocytes. There was no change in density of gemistocytic astrocytes. This suggests that the previously reported decrease in astrocytes in schizophrenia in the subgenual cingulate is accounted for only by a change in fibrillary astrocytes. With recent findings suggesting fibrillary astrocytes regulate synaptic glutamate this morphological change may relate to disregulation of function of the subgenual cingulate cortex.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24374936</pmid><doi>10.1007/s00406-013-0482-4</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-1334 |
| ispartof | European archives of psychiatry and clinical neuroscience, 2014-06, Vol.264 (4), p.357-362 |
| issn | 0940-1334 1433-8491 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1529842249 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Astrocytes - metabolism Cell Count Female Glial Fibrillary Acidic Protein - metabolism Gyrus Cinguli - metabolism Gyrus Cinguli - pathology Humans Male Medicine Medicine & Public Health Middle Aged Mood Disorders - pathology Neurosciences Psychiatry Schizophrenia - pathology Short Communication Young Adult |
| title | Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T00%3A20%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fibrillary%20astrocytes%20are%20decreased%20in%20the%20subgenual%20cingulate%20in%20schizophrenia&rft.jtitle=European%20archives%20of%20psychiatry%20and%20clinical%20neuroscience&rft.au=Williams,%20Matthew&rft.date=2014-06-01&rft.volume=264&rft.issue=4&rft.spage=357&rft.epage=362&rft.pages=357-362&rft.issn=0940-1334&rft.eissn=1433-8491&rft_id=info:doi/10.1007/s00406-013-0482-4&rft_dat=%3Cproquest_cross%3E1529842249%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1530215935&rft_id=info:pmid/24374936&rfr_iscdi=true |