15-Deoxy-Δ12,14-prostaglandin J2 induces PPARγ- and p53-independent apoptosis in rabbit synovial cells

•15D-PGJ2 induced caspases-dependent synovial apoptosis, accompanying with p53 insolubilization.•15D-PGJ2 rendered p53 inactive through its covalent binding to p53.•15D-PGJ2-induced synovial apoptosis was not mediated by PPARγ.•NAC inhibited 15d-PGJ2-induced apoptosis and p53 insolubilization.•Pro-i...

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Veröffentlicht in:	Prostaglandins & other lipid mediators 2014-06, Vol.109-111, p.1-13
Hauptverfasser:	Sakaba, Yukiko, Awata, Hisataka, Morisugi, Toshiaki, Kawakami, Tetsuji, Sakudo, Akikazu, Tanaka, Yasuharu
Format:	Artikel
Sprache:	eng
Schlagworte:	15d-PGJ2 Animals Apoptosis Apoptosis - drug effects Caspase Caspase 3 - metabolism Caspase 7 - metabolism Cell Line Cytokines - pharmacology Enzyme Activation - drug effects Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Humans p53 PPAR gamma - metabolism PPARγ Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - metabolism Prostaglandin D2 - pharmacology Rabbits Signal Transduction - drug effects Solubility - drug effects Synovial Synovial Fluid - cytology Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - metabolism
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