Regulation of alkaline ceramidase activity by the c-Src-mediated pathway

•Ceramidase activity was decreased by c-Src-shRNA and the c-Src inhibitors (74).•Ceramidase activity was enhanced by expression of c-Src and vanadate (69).•Alkaline ceramidase, possibly ACER2, was regulated by c-Src (60).•c-Src-induced activation of ACER2 was independent on Ca2+ activation (69). Cer...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of biochemistry and biophysics 2014-05, Vol.550-551, p.12-19
Hauptverfasser:	Sasaki, Hirotsune, Toyomura, Kaori, Matsuzaki, Wataru, Okamoto, Aya, Yamaguchi, Naoto, Nakamura, Hiroyuki, Murayama, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Chloro-7-nitrobenzofurazan - analogs & derivatives 4-Chloro-7-nitrobenzofurazan - metabolism Alkaline Ceramidase - antagonists & inhibitors Alkaline Ceramidase - genetics Alkaline Ceramidase - metabolism Animals c-Src Calcium - metabolism Caproates - metabolism Cell Line, Tumor Ceramidase Ceramides - metabolism CHO Cells Cricetulus Enzyme Inhibitors - pharmacology Gene Expression Regulation Humans Hydrogen-Ion Concentration Indoles - pharmacology Lyn Lysophospholipids - metabolism Membrane Transport Modulators - pharmacology RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction - drug effects Sphingolipid metabolism Sphingosine - analogs & derivatives Sphingosine - metabolism src-Family Kinases - genetics src-Family Kinases - metabolism Staining and Labeling Sulfonamides - pharmacology Vanadate Vanadates - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!