Fenfluramine-induced behavior changes in rats prefed serotonin-altering amounts of tryptophan and pyridoxine
It has been well established that elevated dietary tryptophan (TRP) levels can increase brain serotonin concentrations, thereby influencing serotonergic transmission. We previously examined interaction between dietary substrate (TRP: 0.15 and 0.6%) and the cofactor precursor (pyridoxine HCl: 3 and 3...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1988-03, Vol.29 (3), p.565-571 |
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| creator | Lee, Nam Soo Wagner, George C. Trout, J.Richard Fisher, Hans |
| description | It has been well established that elevated dietary tryptophan (TRP) levels can increase brain serotonin concentrations, thereby influencing serotonergic transmission. We previously examined interaction between dietary substrate (TRP: 0.15 and 0.6%) and the cofactor precursor (pyridoxine HCl: 3 and 3,000 mg/kg) on brain serotonin metabolism, observing significant increases in serotonin concentrations from such dietary interaction. The present experiments were designed to explore possible behavioral consequences of the substrate-cofactor interaction. After the IP injection of fenfluramine (FA: at 5, 10, 15, and 20 mg/kg), serotonin-mediated behavior traits and the appearance of flushing were observed in rats fed experimental diets as stated above. With a 5 mg/kg dose of FA, a differential dietary effect was most visible. However, at higher FA levels (15 and 20 mg/kg), such dietary effects were no longer discernible. The appearance of flushing was also dependent on dietary TRP intake and the dosage of FA. These results indicate a clear substrate-cofactor interaction on certain serotonin-mediated behavior traits in the rat. |
| doi_str_mv | 10.1016/0091-3057(88)90021-4 |
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We previously examined interaction between dietary substrate (TRP: 0.15 and 0.6%) and the cofactor precursor (pyridoxine HCl: 3 and 3,000 mg/kg) on brain serotonin metabolism, observing significant increases in serotonin concentrations from such dietary interaction. The present experiments were designed to explore possible behavioral consequences of the substrate-cofactor interaction. After the IP injection of fenfluramine (FA: at 5, 10, 15, and 20 mg/kg), serotonin-mediated behavior traits and the appearance of flushing were observed in rats fed experimental diets as stated above. With a 5 mg/kg dose of FA, a differential dietary effect was most visible. However, at higher FA levels (15 and 20 mg/kg), such dietary effects were no longer discernible. The appearance of flushing was also dependent on dietary TRP intake and the dosage of FA. These results indicate a clear substrate-cofactor interaction on certain serotonin-mediated behavior traits in the rat.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(88)90021-4</identifier><identifier>PMID: 3362951</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Behavior ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Biological and medical sciences ; Brain ; Brain - drug effects ; Brain - metabolism ; Diet ; Drug Interactions ; Fenfluramine ; Fenfluramine - pharmacology ; General and cellular metabolism. Vitamins ; Hypothalamus ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Pyridoxine - pharmacology ; Rats ; Rats, Inbred Strains ; Serotonin ; Serotonin - metabolism ; Tryptophan ; Tryptophan - pharmacology ; Vitamin B 6</subject><ispartof>Pharmacology, biochemistry and behavior, 1988-03, Vol.29 (3), p.565-571</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-e9dac318dca0b6b882a503a24c1a292a632238838f7e90af76a0e647a96af55b3</citedby><cites>FETCH-LOGICAL-c448t-e9dac318dca0b6b882a503a24c1a292a632238838f7e90af76a0e647a96af55b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(88)90021-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7123687$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3362951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Nam Soo</creatorcontrib><creatorcontrib>Wagner, George C.</creatorcontrib><creatorcontrib>Trout, J.Richard</creatorcontrib><creatorcontrib>Fisher, Hans</creatorcontrib><title>Fenfluramine-induced behavior changes in rats prefed serotonin-altering amounts of tryptophan and pyridoxine</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>It has been well established that elevated dietary tryptophan (TRP) levels can increase brain serotonin concentrations, thereby influencing serotonergic transmission. We previously examined interaction between dietary substrate (TRP: 0.15 and 0.6%) and the cofactor precursor (pyridoxine HCl: 3 and 3,000 mg/kg) on brain serotonin metabolism, observing significant increases in serotonin concentrations from such dietary interaction. The present experiments were designed to explore possible behavioral consequences of the substrate-cofactor interaction. After the IP injection of fenfluramine (FA: at 5, 10, 15, and 20 mg/kg), serotonin-mediated behavior traits and the appearance of flushing were observed in rats fed experimental diets as stated above. With a 5 mg/kg dose of FA, a differential dietary effect was most visible. However, at higher FA levels (15 and 20 mg/kg), such dietary effects were no longer discernible. The appearance of flushing was also dependent on dietary TRP intake and the dosage of FA. These results indicate a clear substrate-cofactor interaction on certain serotonin-mediated behavior traits in the rat.</description><subject>Animals</subject><subject>Behavior</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Diet</subject><subject>Drug Interactions</subject><subject>Fenfluramine</subject><subject>Fenfluramine - pharmacology</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Hypothalamus</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyridoxine - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>Tryptophan</subject><subject>Tryptophan - pharmacology</subject><subject>Vitamin B 6</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAUxC0EKtuFbwCSD6iCQ4r_xXEuSKiiBalSL3C2XpyX1iixg51U7Levt7vaI-Lkw_xmnjVDyDvOLjnj-jNjLa8kq5uPxnxqGRO8Ui_IhptGVjVvmpdkc0Jek_OcfzPGlNDNGTmTUou25hsyXmMYxjXB5ANWPvSrw552-ACPPibqHiDcY6Y-0ARLpnPCoegZU1xi8KGCccHkwz2FKa6hEHGgS9rNS5yLlULo6bxLvo9_S_4b8mqAMePb47slv66__bz6Xt3e3fy4-npbOaXMUmHbg5Pc9A5YpztjBNRMglCOg2gFaCmENEaaocGWwdBoYKhVA62Goa47uSUXh9w5xT8r5sVOPjscRwgY12x5LVolRfsfIFPP17ZEHUCXYs6lBDsnP0HaWc7sfg27r9ruq7bG2Oc1rCq298f8tZuwP5mO9Rf9w1GH7GAcEgTn8wlruJC6zLklXw4YltIePSabncdQlvIJ3WL76P_9jyds2Kdv</recordid><startdate>19880301</startdate><enddate>19880301</enddate><creator>Lee, Nam Soo</creator><creator>Wagner, George C.</creator><creator>Trout, J.Richard</creator><creator>Fisher, Hans</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7QG</scope></search><sort><creationdate>19880301</creationdate><title>Fenfluramine-induced behavior changes in rats prefed serotonin-altering amounts of tryptophan and pyridoxine</title><author>Lee, Nam Soo ; Wagner, George C. ; Trout, J.Richard ; Fisher, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-e9dac318dca0b6b882a503a24c1a292a632238838f7e90af76a0e647a96af55b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Behavior</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Diet</topic><topic>Drug Interactions</topic><topic>Fenfluramine</topic><topic>Fenfluramine - pharmacology</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Hypothalamus</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyridoxine - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Serotonin</topic><topic>Serotonin - metabolism</topic><topic>Tryptophan</topic><topic>Tryptophan - pharmacology</topic><topic>Vitamin B 6</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Nam Soo</creatorcontrib><creatorcontrib>Wagner, George C.</creatorcontrib><creatorcontrib>Trout, J.Richard</creatorcontrib><creatorcontrib>Fisher, Hans</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Animal Behavior Abstracts</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Nam Soo</au><au>Wagner, George C.</au><au>Trout, J.Richard</au><au>Fisher, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fenfluramine-induced behavior changes in rats prefed serotonin-altering amounts of tryptophan and pyridoxine</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1988-03-01</date><risdate>1988</risdate><volume>29</volume><issue>3</issue><spage>565</spage><epage>571</epage><pages>565-571</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>It has been well established that elevated dietary tryptophan (TRP) levels can increase brain serotonin concentrations, thereby influencing serotonergic transmission. We previously examined interaction between dietary substrate (TRP: 0.15 and 0.6%) and the cofactor precursor (pyridoxine HCl: 3 and 3,000 mg/kg) on brain serotonin metabolism, observing significant increases in serotonin concentrations from such dietary interaction. The present experiments were designed to explore possible behavioral consequences of the substrate-cofactor interaction. After the IP injection of fenfluramine (FA: at 5, 10, 15, and 20 mg/kg), serotonin-mediated behavior traits and the appearance of flushing were observed in rats fed experimental diets as stated above. With a 5 mg/kg dose of FA, a differential dietary effect was most visible. However, at higher FA levels (15 and 20 mg/kg), such dietary effects were no longer discernible. The appearance of flushing was also dependent on dietary TRP intake and the dosage of FA. These results indicate a clear substrate-cofactor interaction on certain serotonin-mediated behavior traits in the rat.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3362951</pmid><doi>10.1016/0091-3057(88)90021-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Behavior Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Brain Brain - drug effects Brain - metabolism Diet Drug Interactions Fenfluramine Fenfluramine - pharmacology General and cellular metabolism. Vitamins Hypothalamus Male Medical sciences Pharmacology. Drug treatments Pyridoxine - pharmacology Rats Rats, Inbred Strains Serotonin Serotonin - metabolism Tryptophan Tryptophan - pharmacology Vitamin B 6 |
| title | Fenfluramine-induced behavior changes in rats prefed serotonin-altering amounts of tryptophan and pyridoxine |
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