Influence of PUVA and UVB Radiation on Delayed Hypersensitivity in the Guinea Pig
Exposure of guinea pigs to UVA (320–400 nm) radiation following administration of 8-methoxypsoralen by gavage (referred to by the acronym, PUVA) or exposure to UVB (290–320 nm) radiation, produced suppression of the cutaneous delayed hypersensitivity reaction at the site of exposure to radiation and...
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| Veröffentlicht in: | J. Invest. Dermatol.; (United States) 1981-06, Vol.76 (6), p.484-488 |
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| container_title | J. Invest. Dermatol.; (United States) |
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| creator | Morison, Warwick L. Parrish, John A. Woehler, Michael E. Krugler, Joel I. Bloch, Kurt J. |
| description | Exposure of guinea pigs to UVA (320–400 nm) radiation following administration of 8-methoxypsoralen by gavage (referred to by the acronym, PUVA) or exposure to UVB (290–320 nm) radiation, produced suppression of the cutaneous delayed hypersensitivity reaction at the site of exposure to radiation and at distant nonexposed sites. In these experiments, the animals were immunized by injection of dinitrophenyl-bovine gamma-globulin (DNP-BGG) in complete Freund's adjuvant and delayed hypersensitivity responses were provoked by intradermal injections of DNP-BGG, DNP and BGG on the flanks. Exposure to erythemogenic doses of either PUVA or UVB radiation for 7days prior to immunization and for the 7days between immunization and challenge (total period of radiation: 14days) produced inhibition of responses to each of the test substances. In addition, treatment with erythemogenic doses of PUVA either for 7days prior to immunization or during the interval between immunization and challenge with DNP-BGG, inhibited the delayed hypersensitivity responses at the site of irradiation and at a nonexposed site. These findings suggest that in vivo exposure to nonionizing radiation leads to both local and systemic alteration of certain immune responses. |
| doi_str_mv | 10.1111/1523-1747.ep12521182 |
| format | Article |
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In these experiments, the animals were immunized by injection of dinitrophenyl-bovine gamma-globulin (DNP-BGG) in complete Freund's adjuvant and delayed hypersensitivity responses were provoked by intradermal injections of DNP-BGG, DNP and BGG on the flanks. Exposure to erythemogenic doses of either PUVA or UVB radiation for 7days prior to immunization and for the 7days between immunization and challenge (total period of radiation: 14days) produced inhibition of responses to each of the test substances. In addition, treatment with erythemogenic doses of PUVA either for 7days prior to immunization or during the interval between immunization and challenge with DNP-BGG, inhibited the delayed hypersensitivity responses at the site of irradiation and at a nonexposed site. These findings suggest that in vivo exposure to nonionizing radiation leads to both local and systemic alteration of certain immune responses.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/1523-1747.ep12521182</identifier><identifier>PMID: 6165782</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>560152 - Radiation Effects on Animals- Animals ; ANIMALS ; ANTICOAGULANTS ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; COUMARINS ; Dinitrobenzenes - immunology ; DRUGS ; ELECTROMAGNETIC RADIATION ; Female ; gamma-Globulins - immunology ; GLOBULINS ; GLOBULINS-GAMMA ; GUINEA PIGS ; HEMATOLOGIC AGENTS ; HETEROCYCLIC COMPOUNDS ; Hypersensitivity, Delayed ; IMMUNE REACTIONS ; Immune Tolerance - radiation effects ; Immunization ; IRRADIATION ; LOCAL IRRADIATION ; MAMMALS ; ORGANIC COMPOUNDS ; ORGANIC OXYGEN COMPOUNDS ; Photochemotherapy - adverse effects ; PROTEINS ; PSORALEN ; PUVA Therapy - adverse effects ; RADIATION EFFECTS ; RADIATION, THERMAL, AND OTHER ENVIRON. 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Invest. Dermatol.; (United States)</title><addtitle>J Invest Dermatol</addtitle><description>Exposure of guinea pigs to UVA (320–400 nm) radiation following administration of 8-methoxypsoralen by gavage (referred to by the acronym, PUVA) or exposure to UVB (290–320 nm) radiation, produced suppression of the cutaneous delayed hypersensitivity reaction at the site of exposure to radiation and at distant nonexposed sites. In these experiments, the animals were immunized by injection of dinitrophenyl-bovine gamma-globulin (DNP-BGG) in complete Freund's adjuvant and delayed hypersensitivity responses were provoked by intradermal injections of DNP-BGG, DNP and BGG on the flanks. Exposure to erythemogenic doses of either PUVA or UVB radiation for 7days prior to immunization and for the 7days between immunization and challenge (total period of radiation: 14days) produced inhibition of responses to each of the test substances. In addition, treatment with erythemogenic doses of PUVA either for 7days prior to immunization or during the interval between immunization and challenge with DNP-BGG, inhibited the delayed hypersensitivity responses at the site of irradiation and at a nonexposed site. These findings suggest that in vivo exposure to nonionizing radiation leads to both local and systemic alteration of certain immune responses.</description><subject>560152 - Radiation Effects on Animals- Animals</subject><subject>ANIMALS</subject><subject>ANTICOAGULANTS</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>COUMARINS</subject><subject>Dinitrobenzenes - immunology</subject><subject>DRUGS</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>Female</subject><subject>gamma-Globulins - immunology</subject><subject>GLOBULINS</subject><subject>GLOBULINS-GAMMA</subject><subject>GUINEA PIGS</subject><subject>HEMATOLOGIC AGENTS</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>Hypersensitivity, Delayed</subject><subject>IMMUNE REACTIONS</subject><subject>Immune Tolerance - radiation effects</subject><subject>Immunization</subject><subject>IRRADIATION</subject><subject>LOCAL IRRADIATION</subject><subject>MAMMALS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC OXYGEN COMPOUNDS</subject><subject>Photochemotherapy - adverse effects</subject><subject>PROTEINS</subject><subject>PSORALEN</subject><subject>PUVA Therapy - adverse effects</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>RADIOSENSITIVITY EFFECTS</subject><subject>RODENTS</subject><subject>ULTRAVIOLET RADIATION</subject><subject>Ultraviolet Rays - adverse effects</subject><subject>VERTEBRATES</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFrFDEUhYModa3-A4Xgg29Tk8wkM3kRatW2ULCKW3wLmZs7NjKb2SaZwv57M-yyfTNcCOSce8n5LiFvOTvj5XzkUtQVb5v2DLdcSMF5J56R1fH5OVkxJkQlmPj9krxK6S9jXDWyOyEniivZdmJFflyHYZwxANJpoLfru3Nqg6Pru8_0p3XeZj8FWuoLjnaHjl7tthgThuSzf_R5R32g-R7p5ewDWnrr_7wmLwY7JnxzuE_J-tvXXxdX1c33y-uL85sKmq7OlWPAQQ913-lWw9AyqS1vnBPSCaud0oPgClgLjcVeDoCg-r5nCmDQoMHVp-T9fu6UsjcJfEa4hykEhGxkidfKrpg-7E3bOD3MmLLZ-AQ4jjbgNCdTYOma67YYm70R4pRSxMFso9_YuDOcmQX3Yq3NwtU84S5t7w7z536D7th04PukB5vniEddKi5Vx4r-aa9jIfXoMS5Blm04H5ccbvL__8A_m26Yjw</recordid><startdate>198106</startdate><enddate>198106</enddate><creator>Morison, Warwick L.</creator><creator>Parrish, John A.</creator><creator>Woehler, Michael E.</creator><creator>Krugler, Joel I.</creator><creator>Bloch, Kurt J.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>OTOTI</scope></search><sort><creationdate>198106</creationdate><title>Influence of PUVA and UVB Radiation on Delayed Hypersensitivity in the Guinea Pig</title><author>Morison, Warwick L. ; Parrish, John A. ; Woehler, Michael E. ; Krugler, Joel I. ; Bloch, Kurt J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-d0c1c9f3b8979cf7059a14dd25d2a9d69f216c07c4aeb5fcec6bbb06ccf9c9cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>560152 - Radiation Effects on Animals- Animals</topic><topic>ANIMALS</topic><topic>ANTICOAGULANTS</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>COUMARINS</topic><topic>Dinitrobenzenes - immunology</topic><topic>DRUGS</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>Female</topic><topic>gamma-Globulins - immunology</topic><topic>GLOBULINS</topic><topic>GLOBULINS-GAMMA</topic><topic>GUINEA PIGS</topic><topic>HEMATOLOGIC AGENTS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>Hypersensitivity, Delayed</topic><topic>IMMUNE REACTIONS</topic><topic>Immune Tolerance - radiation effects</topic><topic>Immunization</topic><topic>IRRADIATION</topic><topic>LOCAL IRRADIATION</topic><topic>MAMMALS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC OXYGEN COMPOUNDS</topic><topic>Photochemotherapy - adverse effects</topic><topic>PROTEINS</topic><topic>PSORALEN</topic><topic>PUVA Therapy - adverse effects</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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Dermatol.; (United States)</jtitle><addtitle>J Invest Dermatol</addtitle><date>1981-06</date><risdate>1981</risdate><volume>76</volume><issue>6</issue><spage>484</spage><epage>488</epage><pages>484-488</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><abstract>Exposure of guinea pigs to UVA (320–400 nm) radiation following administration of 8-methoxypsoralen by gavage (referred to by the acronym, PUVA) or exposure to UVB (290–320 nm) radiation, produced suppression of the cutaneous delayed hypersensitivity reaction at the site of exposure to radiation and at distant nonexposed sites. In these experiments, the animals were immunized by injection of dinitrophenyl-bovine gamma-globulin (DNP-BGG) in complete Freund's adjuvant and delayed hypersensitivity responses were provoked by intradermal injections of DNP-BGG, DNP and BGG on the flanks. Exposure to erythemogenic doses of either PUVA or UVB radiation for 7days prior to immunization and for the 7days between immunization and challenge (total period of radiation: 14days) produced inhibition of responses to each of the test substances. In addition, treatment with erythemogenic doses of PUVA either for 7days prior to immunization or during the interval between immunization and challenge with DNP-BGG, inhibited the delayed hypersensitivity responses at the site of irradiation and at a nonexposed site. These findings suggest that in vivo exposure to nonionizing radiation leads to both local and systemic alteration of certain immune responses.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6165782</pmid><doi>10.1111/1523-1747.ep12521182</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | J. Invest. Dermatol.; (United States), 1981-06, Vol.76 (6), p.484-488 |
| issn | 0022-202X 1523-1747 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | 560152 - Radiation Effects on Animals- Animals ANIMALS ANTICOAGULANTS BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS COUMARINS Dinitrobenzenes - immunology DRUGS ELECTROMAGNETIC RADIATION Female gamma-Globulins - immunology GLOBULINS GLOBULINS-GAMMA GUINEA PIGS HEMATOLOGIC AGENTS HETEROCYCLIC COMPOUNDS Hypersensitivity, Delayed IMMUNE REACTIONS Immune Tolerance - radiation effects Immunization IRRADIATION LOCAL IRRADIATION MAMMALS ORGANIC COMPOUNDS ORGANIC OXYGEN COMPOUNDS Photochemotherapy - adverse effects PROTEINS PSORALEN PUVA Therapy - adverse effects RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOSENSITIVITY EFFECTS RODENTS ULTRAVIOLET RADIATION Ultraviolet Rays - adverse effects VERTEBRATES |
| title | Influence of PUVA and UVB Radiation on Delayed Hypersensitivity in the Guinea Pig |
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