Heparin-binding epidermal growth factor-like growth factor restores Wnt/β-catenin signaling in intestinal stem cells exposed to ischemia/reperfusion injury

Background We have previously demonstrated that heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) protects the intestines from injury in several different experimental animal models. In the current study, we investigated whether the ability of HB-EGF to protect the intestines...

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Veröffentlicht in:	Surgery 2014-06, Vol.155 (6), p.1069-1080
Hauptverfasser:	Chen, Chun-Liang, PhD, Yang, Jixin, MD, James, Iyore O.A., MD, Zhang, Hong-yi, MD, Besner, Gail E., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Fluorescent Antibody Technique Heparin-binding EGF-like Growth Factor Ileum - blood supply Ileum - drug effects Ileum - metabolism Intercellular Signaling Peptides and Proteins - pharmacology Intercellular Signaling Peptides and Proteins - therapeutic use Male Mice Mice, Inbred C57BL Mice, Transgenic Protective Agents - pharmacology Protective Agents - therapeutic use Random Allocation Receptors, G-Protein-Coupled - metabolism Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Stem Cells - drug effects Stem Cells - metabolism Surgery Wnt Signaling Pathway - drug effects
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