Connexin a check-point component of cell apoptosis in normal and physiopathological conditions

Gap junction protein connexins (Cxs) play essential roles in cell homeostasis, growth, differentiation and death. Therefore, Cx dysfunction has been associated with many diseases and with tumor development. Cxs control cell apoptosis through different molecular mechanisms. First, gap junction channe...

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Veröffentlicht in:	Biochimie 2014-06, Vol.101, p.1-9
Hauptverfasser:	Carette, Diane, Gilleron, Jérome, Chevallier, Daniel, Segretain, Dominique, Pointis, Georges
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Cancer therapy Cell Cycle Checkpoints Connexin Connexins - physiology Gap junction Gap Junctions - physiology Hemichannel Humans Mitochondria - metabolism Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Tumor
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