Necrosis factor-alpha (TNF-α) response in human hepatoma HepG2 cells treated with hepatotoxic agents

The liver plays an essential role in xenobiotic metabolism including alcohol and drugs. Oxidative stress that usually occurs during the hepatic metabolism participates in the pathogenesis of liver disease. Inflammatory cytokines that exist in liver in both physiological and pathophysiological condit...

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Veröffentlicht in:	Pharmazie 2014-05, Vol.69 (5), p.379-384
Hauptverfasser:	Xie, Wenyan, Sun, Jianguo, Zhang, Xiaoying, Melzig
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde - toxicity Acetaminophen - toxicity Cell Line Cell Survival - drug effects Central Nervous System Depressants - toxicity Chemical and Drug Induced Liver Injury - metabolism Coloring Agents Ethanol - toxicity Humans Liver - drug effects Liver - metabolism tert-Butylhydroperoxide - toxicity Tetrazolium Salts Thiazoles Tumor Necrosis Factor-alpha - metabolism
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