Early Host Tissue Response to Different Types of Vascular Prostheses Coated with Silver Acetate or Vaporized Metallic Silver
Objectives In vascular surgery, the infection of prosthetic vascular grafts represents a serious life-threatening complication. Due to the increasing resistance of hospital micro-organisms to standard antibiotic therapies, maximum effort should be put in the primary prevention of such infections. Fo...
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| Veröffentlicht in: | European journal of vascular and endovascular surgery 2014-06, Vol.47 (6), p.680-688 |
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| container_title | European journal of vascular and endovascular surgery |
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| creator | Jeanmonod, P Laschke, M.W Gola, N von Heesen, M Glanemann, M Menger, M.D Moussavian, M.R |
| description | Objectives In vascular surgery, the infection of prosthetic vascular grafts represents a serious life-threatening complication. Due to the increasing resistance of hospital micro-organisms to standard antibiotic therapies, maximum effort should be put in the primary prevention of such infections. For this purpose, grafts may be coated with different antibacterial silver formulations. In the present study the different effects of silver acetate-coating and vaporized metallic silver-coating on the vascularization and perigraft inflammation during the initial phase after implantation of Intergard Silver (IS) and Silver Graft (SG) were compared. Methods Silver acetate-coated IS and vaporized metallic silver-coated SG were implanted into the dorsal skinfold chamber of C57BL/6 mice ( n = 8 per group) to study angiogenesis and leukocyte inflammation at the implantation site by means of repetitive intravital fluorescence microscopy over a 14-day period. At the end of the in vivo experiments, apoptosis and cell proliferation in the newly developed granulation tissue surrounding the implants was analyzed by immunohistochemistry. Results IS exhibited an improved vascularization, resulting in a significantly higher functional capillary density when compared to SG. Moreover, the leukocyte inflammatory response to IS was less pronounced, as indicated by a reduced number of adherent leukocytes in perigraft venules. This was associated with a higher proliferative activity of the granulation tissue incorporating the IS when compared to SG. The numbers of apoptotic cells in the perigraft tissue were low and did not differ between the two groups. Conclusion Silver acetate-coated IS exhibits an improved vascularization and reduced perigraft inflammation during the first 14 days after implantation when compared to vaporized metallic silver-coated SG. This may contribute to reducing the risk of early perigraft seroma formation and subsequent infection. |
| doi_str_mv | 10.1016/j.ejvs.2014.03.006 |
| format | Article |
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Due to the increasing resistance of hospital micro-organisms to standard antibiotic therapies, maximum effort should be put in the primary prevention of such infections. For this purpose, grafts may be coated with different antibacterial silver formulations. In the present study the different effects of silver acetate-coating and vaporized metallic silver-coating on the vascularization and perigraft inflammation during the initial phase after implantation of Intergard Silver (IS) and Silver Graft (SG) were compared. Methods Silver acetate-coated IS and vaporized metallic silver-coated SG were implanted into the dorsal skinfold chamber of C57BL/6 mice ( n = 8 per group) to study angiogenesis and leukocyte inflammation at the implantation site by means of repetitive intravital fluorescence microscopy over a 14-day period. At the end of the in vivo experiments, apoptosis and cell proliferation in the newly developed granulation tissue surrounding the implants was analyzed by immunohistochemistry. Results IS exhibited an improved vascularization, resulting in a significantly higher functional capillary density when compared to SG. Moreover, the leukocyte inflammatory response to IS was less pronounced, as indicated by a reduced number of adherent leukocytes in perigraft venules. This was associated with a higher proliferative activity of the granulation tissue incorporating the IS when compared to SG. The numbers of apoptotic cells in the perigraft tissue were low and did not differ between the two groups. Conclusion Silver acetate-coated IS exhibits an improved vascularization and reduced perigraft inflammation during the first 14 days after implantation when compared to vaporized metallic silver-coated SG. This may contribute to reducing the risk of early perigraft seroma formation and subsequent infection.</description><identifier>ISSN: 1078-5884</identifier><identifier>EISSN: 1532-2165</identifier><identifier>DOI: 10.1016/j.ejvs.2014.03.006</identifier><identifier>PMID: 24726145</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject><![CDATA[Acetates - administration & dosage ; Acetates - adverse effects ; Angiogenesis ; Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - adverse effects ; Apoptosis ; Blood Vessel Prosthesis - adverse effects ; Blood Vessel Prosthesis Implantation - adverse effects ; Blood Vessel Prosthesis Implantation - instrumentation ; Cell Proliferation ; Coated Materials, Biocompatible ; Dacron grafts ; Dorsal skinfold chamber ; Foreign-Body Reaction - etiology ; Foreign-Body Reaction - pathology ; Foreign-Body Reaction - prevention & control ; Inflammation ; Inflammation - etiology ; Inflammation - pathology ; Inflammation - prevention & control ; Mice ; Mice, Inbred C57BL ; Neovascularization, Physiologic ; Prosthesis-Related Infections - etiology ; Prosthesis-Related Infections - prevention & control ; Silver acetate ; Silver Compounds - administration & dosage ; Silver Compounds - adverse effects ; Surgery ; Time Factors ; Vaporized silver ; Vascularization]]></subject><ispartof>European journal of vascular and endovascular surgery, 2014-06, Vol.47 (6), p.680-688</ispartof><rights>European Society for Vascular Surgery</rights><rights>2014 European Society for Vascular Surgery</rights><rights>Copyright © 2014 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-7e6ec500ad5b24665c9768ca95ece16673ecd9a04680cab89750094ec3b61f743</citedby><cites>FETCH-LOGICAL-c455t-7e6ec500ad5b24665c9768ca95ece16673ecd9a04680cab89750094ec3b61f743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejvs.2014.03.006$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24726145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeanmonod, P</creatorcontrib><creatorcontrib>Laschke, M.W</creatorcontrib><creatorcontrib>Gola, N</creatorcontrib><creatorcontrib>von Heesen, M</creatorcontrib><creatorcontrib>Glanemann, M</creatorcontrib><creatorcontrib>Menger, M.D</creatorcontrib><creatorcontrib>Moussavian, M.R</creatorcontrib><title>Early Host Tissue Response to Different Types of Vascular Prostheses Coated with Silver Acetate or Vaporized Metallic Silver</title><title>European journal of vascular and endovascular surgery</title><addtitle>Eur J Vasc Endovasc Surg</addtitle><description>Objectives In vascular surgery, the infection of prosthetic vascular grafts represents a serious life-threatening complication. Due to the increasing resistance of hospital micro-organisms to standard antibiotic therapies, maximum effort should be put in the primary prevention of such infections. For this purpose, grafts may be coated with different antibacterial silver formulations. In the present study the different effects of silver acetate-coating and vaporized metallic silver-coating on the vascularization and perigraft inflammation during the initial phase after implantation of Intergard Silver (IS) and Silver Graft (SG) were compared. Methods Silver acetate-coated IS and vaporized metallic silver-coated SG were implanted into the dorsal skinfold chamber of C57BL/6 mice ( n = 8 per group) to study angiogenesis and leukocyte inflammation at the implantation site by means of repetitive intravital fluorescence microscopy over a 14-day period. At the end of the in vivo experiments, apoptosis and cell proliferation in the newly developed granulation tissue surrounding the implants was analyzed by immunohistochemistry. Results IS exhibited an improved vascularization, resulting in a significantly higher functional capillary density when compared to SG. Moreover, the leukocyte inflammatory response to IS was less pronounced, as indicated by a reduced number of adherent leukocytes in perigraft venules. This was associated with a higher proliferative activity of the granulation tissue incorporating the IS when compared to SG. The numbers of apoptotic cells in the perigraft tissue were low and did not differ between the two groups. Conclusion Silver acetate-coated IS exhibits an improved vascularization and reduced perigraft inflammation during the first 14 days after implantation when compared to vaporized metallic silver-coated SG. This may contribute to reducing the risk of early perigraft seroma formation and subsequent infection.</description><subject>Acetates - administration & dosage</subject><subject>Acetates - adverse effects</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Apoptosis</subject><subject>Blood Vessel Prosthesis - adverse effects</subject><subject>Blood Vessel Prosthesis Implantation - adverse effects</subject><subject>Blood Vessel Prosthesis Implantation - instrumentation</subject><subject>Cell Proliferation</subject><subject>Coated Materials, Biocompatible</subject><subject>Dacron grafts</subject><subject>Dorsal skinfold chamber</subject><subject>Foreign-Body Reaction - etiology</subject><subject>Foreign-Body Reaction - pathology</subject><subject>Foreign-Body Reaction - prevention & control</subject><subject>Inflammation</subject><subject>Inflammation - etiology</subject><subject>Inflammation - pathology</subject><subject>Inflammation - prevention & control</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neovascularization, Physiologic</subject><subject>Prosthesis-Related Infections - etiology</subject><subject>Prosthesis-Related Infections - prevention & control</subject><subject>Silver acetate</subject><subject>Silver Compounds - administration & dosage</subject><subject>Silver Compounds - adverse effects</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Vaporized silver</subject><subject>Vascularization</subject><issn>1078-5884</issn><issn>1532-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhiMEoqXwBzggH7kk2PFHEgkhVUtpkYpA9ONqeZ2J6uCNU0-yaFF_fB3twoFDT7ZmnnekeSbL3jJaMMrUh76AfotFSZkoKC8oVc-yYyZ5mZdMyefpT6s6l3UtjrJXiD2lVDIuX2ZHpahKxYQ8zh7OTPQ7chFwItcOcQbyE3AMAwKZAvnsug4iDKm5GwFJ6MitQTt7E8mPmEJ3gKm8CmaClvx20x25cn4LkZxamFKRhJgSY4juTwK-pZr3zh6g19mLzniEN4f3JLv5cna9usgvv59_XZ1e5lZIOeUVKLCSUtPKdSmUkrapVG1NI8ECU6riYNvGUKFqas26bqoENwIsXyvWVYKfZO_3c8cY7mfASW8cWvDeDBBm1EyWdV1xyVVCyz1q03YYodNjdBsTd5pRvVjXvV6s68W6plwn6yn07jB_Xm-g_Rf5qzkBH_cApC23DqJG62Cw0LoIdtJtcE_P__Rf3Ho3OGv8L9gB9mGOQ_KnmcZSU3213H05OxOUsiSIPwKcLKlZ</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Jeanmonod, P</creator><creator>Laschke, M.W</creator><creator>Gola, N</creator><creator>von Heesen, M</creator><creator>Glanemann, M</creator><creator>Menger, M.D</creator><creator>Moussavian, M.R</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Early Host Tissue Response to Different Types of Vascular Prostheses Coated with Silver Acetate or Vaporized Metallic Silver</title><author>Jeanmonod, P ; Laschke, M.W ; Gola, N ; von Heesen, M ; Glanemann, M ; Menger, M.D ; Moussavian, M.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-7e6ec500ad5b24665c9768ca95ece16673ecd9a04680cab89750094ec3b61f743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetates - administration & dosage</topic><topic>Acetates - adverse effects</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Apoptosis</topic><topic>Blood Vessel Prosthesis - adverse effects</topic><topic>Blood Vessel Prosthesis Implantation - adverse effects</topic><topic>Blood Vessel Prosthesis Implantation - instrumentation</topic><topic>Cell Proliferation</topic><topic>Coated Materials, Biocompatible</topic><topic>Dacron grafts</topic><topic>Dorsal skinfold chamber</topic><topic>Foreign-Body Reaction - etiology</topic><topic>Foreign-Body Reaction - pathology</topic><topic>Foreign-Body Reaction - prevention & control</topic><topic>Inflammation</topic><topic>Inflammation - etiology</topic><topic>Inflammation - pathology</topic><topic>Inflammation - prevention & control</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neovascularization, Physiologic</topic><topic>Prosthesis-Related Infections - etiology</topic><topic>Prosthesis-Related Infections - prevention & control</topic><topic>Silver acetate</topic><topic>Silver Compounds - administration & dosage</topic><topic>Silver Compounds - adverse effects</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Vaporized silver</topic><topic>Vascularization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeanmonod, P</creatorcontrib><creatorcontrib>Laschke, M.W</creatorcontrib><creatorcontrib>Gola, N</creatorcontrib><creatorcontrib>von Heesen, M</creatorcontrib><creatorcontrib>Glanemann, M</creatorcontrib><creatorcontrib>Menger, M.D</creatorcontrib><creatorcontrib>Moussavian, M.R</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of vascular and endovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeanmonod, P</au><au>Laschke, M.W</au><au>Gola, N</au><au>von Heesen, M</au><au>Glanemann, M</au><au>Menger, M.D</au><au>Moussavian, M.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Host Tissue Response to Different Types of Vascular Prostheses Coated with Silver Acetate or Vaporized Metallic Silver</atitle><jtitle>European journal of vascular and endovascular surgery</jtitle><addtitle>Eur J Vasc Endovasc Surg</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>47</volume><issue>6</issue><spage>680</spage><epage>688</epage><pages>680-688</pages><issn>1078-5884</issn><eissn>1532-2165</eissn><abstract>Objectives In vascular surgery, the infection of prosthetic vascular grafts represents a serious life-threatening complication. Due to the increasing resistance of hospital micro-organisms to standard antibiotic therapies, maximum effort should be put in the primary prevention of such infections. For this purpose, grafts may be coated with different antibacterial silver formulations. In the present study the different effects of silver acetate-coating and vaporized metallic silver-coating on the vascularization and perigraft inflammation during the initial phase after implantation of Intergard Silver (IS) and Silver Graft (SG) were compared. Methods Silver acetate-coated IS and vaporized metallic silver-coated SG were implanted into the dorsal skinfold chamber of C57BL/6 mice ( n = 8 per group) to study angiogenesis and leukocyte inflammation at the implantation site by means of repetitive intravital fluorescence microscopy over a 14-day period. At the end of the in vivo experiments, apoptosis and cell proliferation in the newly developed granulation tissue surrounding the implants was analyzed by immunohistochemistry. Results IS exhibited an improved vascularization, resulting in a significantly higher functional capillary density when compared to SG. Moreover, the leukocyte inflammatory response to IS was less pronounced, as indicated by a reduced number of adherent leukocytes in perigraft venules. This was associated with a higher proliferative activity of the granulation tissue incorporating the IS when compared to SG. The numbers of apoptotic cells in the perigraft tissue were low and did not differ between the two groups. Conclusion Silver acetate-coated IS exhibits an improved vascularization and reduced perigraft inflammation during the first 14 days after implantation when compared to vaporized metallic silver-coated SG. This may contribute to reducing the risk of early perigraft seroma formation and subsequent infection.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24726145</pmid><doi>10.1016/j.ejvs.2014.03.006</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetates - administration & dosage Acetates - adverse effects Angiogenesis Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Apoptosis Blood Vessel Prosthesis - adverse effects Blood Vessel Prosthesis Implantation - adverse effects Blood Vessel Prosthesis Implantation - instrumentation Cell Proliferation Coated Materials, Biocompatible Dacron grafts Dorsal skinfold chamber Foreign-Body Reaction - etiology Foreign-Body Reaction - pathology Foreign-Body Reaction - prevention & control Inflammation Inflammation - etiology Inflammation - pathology Inflammation - prevention & control Mice Mice, Inbred C57BL Neovascularization, Physiologic Prosthesis-Related Infections - etiology Prosthesis-Related Infections - prevention & control Silver acetate Silver Compounds - administration & dosage Silver Compounds - adverse effects Surgery Time Factors Vaporized silver Vascularization |
| title | Early Host Tissue Response to Different Types of Vascular Prostheses Coated with Silver Acetate or Vaporized Metallic Silver |
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