Susceptibility to Rheumatoid Arthritis Maps to a T-Cell Epitope Shared by the HLA-Dw4 DR β -1 Chain and the Epstein-Barr Virus Glycoprotein gp110
Rheumatoid arthritis is associated with the HLA antigen HLA-DR4. Disease susceptibility maps to the amino acid sequence QKRAA located in the third hypervariable region of the DR β -1 chain. This region is thought to be a site of recognition for the T-cell antigen receptor. We searched for an antigen...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1989-07, Vol.86 (13), p.5104-5108 |
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| creator | Roudier, Jean Petersen, Jorgen Rhodes, Gary H. Luka, Janos Carson, Dennis A. |
| description | Rheumatoid arthritis is associated with the HLA antigen HLA-DR4. Disease susceptibility maps to the amino acid sequence QKRAA located in the third hypervariable region of the DR β -1 chain. This region is thought to be a site of recognition for the T-cell antigen receptor. We searched for an antigen in the human environment that could induce T-cell recognition of this sequence. An analysis of protein and DNA databases revealed that the Epstein-Barr virus glycoprotein gp110, which is encoded by the BALF4 open reading frame, contains the sequence QKRAAQRAA, which is highly homologous to the rheumatoid arthritis susceptibility determinant. Experiments using antibodies to synthetic peptides showed that the QKRAA determinant is expressed on the gp110 protein. Humans with serologic evidence of Epstein-Barr virus infection had serum antibodies to gp110 and peripheral blood T cells that recognized peptides from gp110 and HLA-Dw4 encompassing the QKRAA determinant. |
| doi_str_mv | 10.1073/pnas.86.13.5104 |
| format | Article |
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Disease susceptibility maps to the amino acid sequence QKRAA located in the third hypervariable region of the DR β -1 chain. This region is thought to be a site of recognition for the T-cell antigen receptor. We searched for an antigen in the human environment that could induce T-cell recognition of this sequence. An analysis of protein and DNA databases revealed that the Epstein-Barr virus glycoprotein gp110, which is encoded by the BALF4 open reading frame, contains the sequence QKRAAQRAA, which is highly homologous to the rheumatoid arthritis susceptibility determinant. Experiments using antibodies to synthetic peptides showed that the QKRAA determinant is expressed on the gp110 protein. Humans with serologic evidence of Epstein-Barr virus infection had serum antibodies to gp110 and peripheral blood T cells that recognized peptides from gp110 and HLA-Dw4 encompassing the QKRAA determinant.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.86.13.5104</identifier><identifier>PMID: 2472638</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Amino Acid Sequence ; Amino acids ; Antibodies ; Antigens ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - immunology ; Biological and medical sciences ; Cultured cells ; Enzyme linked immunosorbent assay ; Epitopes - analysis ; Epstein Barr virus infections ; Epstein-Barr virus ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Glycoproteins ; Histocompatibility antigens (hla, h-2 and other systems) ; HLA antigens ; HLA-D Antigens - genetics ; Humans ; Immunoglobulin G - genetics ; Immunoglobulin M - genetics ; Macromolecular Substances ; Molecular immunology ; Molecular Sequence Data ; Rheumatoid arthritis ; T lymphocytes ; T-Lymphocytes - immunology ; Viral Proteins - genetics</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1989-07, Vol.86 (13), p.5104-5108</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-6759363c58c7ae023d7a74cf6836235b830ac5f395552a95925f717fe5a0a66e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/86/13.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/34054$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/34054$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6925479$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2472638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roudier, Jean</creatorcontrib><creatorcontrib>Petersen, Jorgen</creatorcontrib><creatorcontrib>Rhodes, Gary H.</creatorcontrib><creatorcontrib>Luka, Janos</creatorcontrib><creatorcontrib>Carson, Dennis A.</creatorcontrib><title>Susceptibility to Rheumatoid Arthritis Maps to a T-Cell Epitope Shared by the HLA-Dw4 DR β -1 Chain and the Epstein-Barr Virus Glycoprotein gp110</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Rheumatoid arthritis is associated with the HLA antigen HLA-DR4. Disease susceptibility maps to the amino acid sequence QKRAA located in the third hypervariable region of the DR β -1 chain. This region is thought to be a site of recognition for the T-cell antigen receptor. We searched for an antigen in the human environment that could induce T-cell recognition of this sequence. An analysis of protein and DNA databases revealed that the Epstein-Barr virus glycoprotein gp110, which is encoded by the BALF4 open reading frame, contains the sequence QKRAAQRAA, which is highly homologous to the rheumatoid arthritis susceptibility determinant. Experiments using antibodies to synthetic peptides showed that the QKRAA determinant is expressed on the gp110 protein. Humans with serologic evidence of Epstein-Barr virus infection had serum antibodies to gp110 and peripheral blood T cells that recognized peptides from gp110 and HLA-Dw4 encompassing the QKRAA determinant.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Biological and medical sciences</subject><subject>Cultured cells</subject><subject>Enzyme linked immunosorbent assay</subject><subject>Epitopes - analysis</subject><subject>Epstein Barr virus infections</subject><subject>Epstein-Barr virus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Glycoproteins</subject><subject>Histocompatibility antigens (hla, h-2 and other systems)</subject><subject>HLA antigens</subject><subject>HLA-D Antigens - genetics</subject><subject>Humans</subject><subject>Immunoglobulin G - genetics</subject><subject>Immunoglobulin M - genetics</subject><subject>Macromolecular Substances</subject><subject>Molecular immunology</subject><subject>Molecular Sequence Data</subject><subject>Rheumatoid arthritis</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>Viral Proteins - genetics</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhS0EKiWwRkICeYFgNan_PbNgEdLQIgUhtYWt5TiejitnPLU9QF6DR-FBeCZmSAiwgdWVfL5zr-89ADzGaIqRpCddq9O0FFNMpxwjdgccY1ThQrAK3QXHCBFZlIyw--BBSjcIoYqX6AgcESaJoOUx-HrZJ2O77FbOu7yFOcCLxvYbnYNbw1nMTXTZJfhOd2kUNbwq5tZ7uOhcDp2Fl42Odg1Xg7Wx8Hw5K04_M3h6Ab9_gwWG80a7Fup2_VNedClb1xavdYzwo4t9gmd-a0IXw_gOrzuM0UNwr9Y-2Uf7OgEf3iyu5ufF8v3Z2_lsWRhOcC6E5BUV1PDSSG0RoWupJTO1KKkglK9KirThNa0450RXvCK8lljWlmukhbB0Al7t-nb9amPXxrY5aq-66DY6blXQTv2ttK5R1-GTIpXkgg_-F3t_DLe9TVlt3HBL73VrQ5-UrJAUJaP_BTEnJRfDBhNwsgNNDClFWx8-g5Ea41Zj3KoUClM1xj04nv65w4Hf5zvoz_e6Tkb7OurWuHTAxHAUJqsBe7nHxv6_1N9zVN17n-2XPJDP_kkOwJMdcJNyiAeCMsQZ_QGx2NPP</recordid><startdate>19890701</startdate><enddate>19890701</enddate><creator>Roudier, Jean</creator><creator>Petersen, Jorgen</creator><creator>Rhodes, Gary H.</creator><creator>Luka, Janos</creator><creator>Carson, Dennis A.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19890701</creationdate><title>Susceptibility to Rheumatoid Arthritis Maps to a T-Cell Epitope Shared by the HLA-Dw4 DR β -1 Chain and the Epstein-Barr Virus Glycoprotein gp110</title><author>Roudier, Jean ; Petersen, Jorgen ; Rhodes, Gary H. ; Luka, Janos ; Carson, Dennis A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-6759363c58c7ae023d7a74cf6836235b830ac5f395552a95925f717fe5a0a66e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Biological and medical sciences</topic><topic>Cultured cells</topic><topic>Enzyme linked immunosorbent assay</topic><topic>Epitopes - analysis</topic><topic>Epstein Barr virus infections</topic><topic>Epstein-Barr virus</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Glycoproteins</topic><topic>Histocompatibility antigens (hla, h-2 and other systems)</topic><topic>HLA antigens</topic><topic>HLA-D Antigens - genetics</topic><topic>Humans</topic><topic>Immunoglobulin G - genetics</topic><topic>Immunoglobulin M - genetics</topic><topic>Macromolecular Substances</topic><topic>Molecular immunology</topic><topic>Molecular Sequence Data</topic><topic>Rheumatoid arthritis</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>Viral Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roudier, Jean</creatorcontrib><creatorcontrib>Petersen, Jorgen</creatorcontrib><creatorcontrib>Rhodes, Gary H.</creatorcontrib><creatorcontrib>Luka, Janos</creatorcontrib><creatorcontrib>Carson, Dennis A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roudier, Jean</au><au>Petersen, Jorgen</au><au>Rhodes, Gary H.</au><au>Luka, Janos</au><au>Carson, Dennis A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Susceptibility to Rheumatoid Arthritis Maps to a T-Cell Epitope Shared by the HLA-Dw4 DR β -1 Chain and the Epstein-Barr Virus Glycoprotein gp110</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1989-07-01</date><risdate>1989</risdate><volume>86</volume><issue>13</issue><spage>5104</spage><epage>5108</epage><pages>5104-5108</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Rheumatoid arthritis is associated with the HLA antigen HLA-DR4. Disease susceptibility maps to the amino acid sequence QKRAA located in the third hypervariable region of the DR β -1 chain. This region is thought to be a site of recognition for the T-cell antigen receptor. We searched for an antigen in the human environment that could induce T-cell recognition of this sequence. An analysis of protein and DNA databases revealed that the Epstein-Barr virus glycoprotein gp110, which is encoded by the BALF4 open reading frame, contains the sequence QKRAAQRAA, which is highly homologous to the rheumatoid arthritis susceptibility determinant. Experiments using antibodies to synthetic peptides showed that the QKRAA determinant is expressed on the gp110 protein. Humans with serologic evidence of Epstein-Barr virus infection had serum antibodies to gp110 and peripheral blood T cells that recognized peptides from gp110 and HLA-Dw4 encompassing the QKRAA determinant.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2472638</pmid><doi>10.1073/pnas.86.13.5104</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Amino Acid Sequence Amino acids Antibodies Antigens Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Biological and medical sciences Cultured cells Enzyme linked immunosorbent assay Epitopes - analysis Epstein Barr virus infections Epstein-Barr virus Fundamental and applied biological sciences. Psychology Fundamental immunology Glycoproteins Histocompatibility antigens (hla, h-2 and other systems) HLA antigens HLA-D Antigens - genetics Humans Immunoglobulin G - genetics Immunoglobulin M - genetics Macromolecular Substances Molecular immunology Molecular Sequence Data Rheumatoid arthritis T lymphocytes T-Lymphocytes - immunology Viral Proteins - genetics |
| title | Susceptibility to Rheumatoid Arthritis Maps to a T-Cell Epitope Shared by the HLA-Dw4 DR β -1 Chain and the Epstein-Barr Virus Glycoprotein gp110 |
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