Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome

Cushing's syndrome is caused by excess cortisol production from the adrenocortical gland. In corticotropin-independent Cushing's syndrome, the excess cortisol production is primarily attributed to an adrenocortical adenoma, in which the underlying molecular pathogenesis has been poorly und...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2014-05, Vol.344 (6186), p.917-920
Hauptverfasser:	Sato, Yusuke, Maekawa, Shigekatsu, Ishii, Ryohei, Sanada, Masashi, Morikawa, Teppei, Shiraishi, Yuichi, Yoshida, Kenichi, Nagata, Yasunobu, Sato-Otsubo, Aiko, Yoshizato, Tetsuichi, Suzuki, Hiromichi, Shiozawa, Yusuke, Kataoka, Keisuke, Kon, Ayana, Aoki, Kosuke, Chiba, Kenichi, Tanaka, Hiroko, Kume, Haruki, Miyano, Satoru, Fukayama, Masashi, Nureki, Osamu, Homma, Yukio, Ogawa, Seishi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma Adrenal Cortex Neoplasms - genetics Adrenal glands Adrenocortical Adenoma - genetics Adrenocorticotropic Hormone - metabolism Animals Antibodies Catalytic Domain - genetics Cushing Syndrome - genetics Cushing Syndrome - metabolism Cushings syndrome Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - genetics Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - metabolism Disease DNA Mutational Analysis DNA sequence analysis Etiology Gene expression Genetic mutation GTP-Binding Protein alpha Subunits - genetics HEK293 Cells Humans Mice Mutation NIH 3T3 Cells Pathology PC12 Cells Rats Somatic mutation Steroids T tests Tumors
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