Perfluorocarbon emulsion improves oxygen transport of normal and sickle cell human blood in vitro

Perfluorocarbons (PFC) are compounds with high gas solubility that could help deliver O2 to tissues and have been suggested as adjunct therapy to ischemia. Using a newly designed in vitro system, we tested the hypothesis that a third generation PFC emulsion (Oxycyte) increased O2 transport of blood...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2014-07, Vol.102 (7), p.2105-2115
Hauptverfasser:	Torres Filho, Ivo P., Pedro, José Ricardo P., Narayanan, Srinivasan V., Nguyen, Nguyen M., Roseff, Susan D., Spiess, Bruce D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Sickle Cell - blood Anemias. Hemoglobinopathies Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences cardiopulmonary bypass Case-Control Studies Diseases of red blood cells Emulsions facilitated diffusion Fluorocarbons Hematologic and hematopoietic diseases Humans Medical sciences Oxygen - blood oxygen extraction ratio oxygen transport perfluorocarbon emulsion sickle cell disease Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thoracic and cardiovascular surgery. Cardiopulmonary bypass
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