Systemic administration of atorvastatin improves locomotor functions and hyperacute-acute response after experimental spinal cord injury: an ultrastructural and biochemical analysis

Spinal cord injury (SCI) is characterized by posttraumatic inflammatory cascades including excitotoxicity, oxidative stress, and apoptosis. Agents against neuroinflammation are the current scope of studies on experimental SCI with promising results. Thirty-two male Sprague-Dawley rats weighing 250-3...

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Veröffentlicht in:	Turkish neurosurgery 2014, Vol.24 (3), p.337-343
Hauptverfasser:	Nacar, Osman Arikan, Eroglu, Hakan, Cetinalp, Nuri Eralp, Menekse, Guner, Yildirim, Ali Erdem, Uckun, Ozhan Merzuk, Daglioglu, Ergun, Turkoglu, Omer Faruk, Belen, Ahmet Deniz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atorvastatin Calcium Heptanoic Acids - pharmacology Interleukin-1beta - metabolism Interleukin-6 - metabolism Lipid Peroxidation - drug effects Male Motor Activity - drug effects Pyrroles - pharmacology Random Allocation Rats Rats, Sprague-Dawley Spinal Cord - drug effects Spinal Cord - ultrastructure Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology
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