Melatonin deprival modifies follicular and corpus luteal growth dynamics in a sheep model
This study assessed the effect of melatonin deprival on ovarian status and function in sheep. Experimental procedures were carried out within two consecutive breeding seasons. Animals were divided into two groups: pinealectomised (n=6) and sham-operated (n=6). The completeness of the pineal gland re...
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| Veröffentlicht in: | Reproduction (Cambridge, England) England), 2014-06, Vol.147 (6), p.885-895 |
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| creator | Manca, Maria Elena Manunta, Maria Lucia Spezzigu, Antonio Torres-Rovira, Laura Gonzalez-Bulnes, Antonio Pasciu, Valeria Piu, Peter Leoni, Giovanni G Succu, Sara Chesneau, Didier Naitana, Salvatore Berlinguer, Fiammetta |
| description | This study assessed the effect of melatonin deprival on ovarian status and function in sheep. Experimental procedures were carried out within two consecutive breeding seasons. Animals were divided into two groups: pinealectomised (n=6) and sham-operated (n=6). The completeness of the pineal gland removal was confirmed by the plasma concentration of melatonin. Ovarian status was monitored by ovarian ultrasonography for 1 year to study reproductive seasonality. Follicular and corpus luteal growth dynamics were assessed during an induced oestrous cycle. As the effects of melatonin on the ovary may also be mediated by its antioxidant properties, plasma Trolox equivalent antioxidant capacity (TEAC) was determined monthly for 1 year. Pinealectomy significantly extended the breeding season (310±24.7 vs 217.5±24.7 days in controls; P |
| doi_str_mv | 10.1530/REP-13-0405 |
| format | Article |
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Experimental procedures were carried out within two consecutive breeding seasons. Animals were divided into two groups: pinealectomised (n=6) and sham-operated (n=6). The completeness of the pineal gland removal was confirmed by the plasma concentration of melatonin. Ovarian status was monitored by ovarian ultrasonography for 1 year to study reproductive seasonality. Follicular and corpus luteal growth dynamics were assessed during an induced oestrous cycle. As the effects of melatonin on the ovary may also be mediated by its antioxidant properties, plasma Trolox equivalent antioxidant capacity (TEAC) was determined monthly for 1 year. Pinealectomy significantly extended the breeding season (310±24.7 vs 217.5±24.7 days in controls; P<0.05). Both pinealectomised and sham-operated ewes showed a well-defined wave-like pattern of follicle dynamics; however, melatonin deficiency caused fewer waves during the oestrous cycle (4.3±0.2 vs 5.2±0.2; P<0.05), because waves were 1 day longer when compared with the controls (7.2±0.3 vs 6.1±0.3; P<0.05). The mean area of the corpora lutea (105.4±5.9 vs 65.4±5.9 mm2; P<0.05) and plasma progesterone levels (7.1±0.7 vs 4.9±0.6 ng/ml; P<0.05) were significantly higher in sham-operated ewes compared with pinealectomised ewes. In addition, TEAC values were significantly lower in pinealectomised ewes compared with control ones. These data suggest that melatonin, besides exerting its well-known role in the synchronisation of seasonal reproductive fluctuations, influences the growth pattern of the follicles and the steroidogenic capacity of the corpus luteum.Free Italian n Italian translation of this is freely available at http://www.reproduction-online.org/content/147/6/885/suppl/DC1.</description><identifier>ISSN: 1470-1626</identifier><identifier>EISSN: 1741-7899</identifier><identifier>DOI: 10.1530/REP-13-0405</identifier><identifier>PMID: 24570480</identifier><language>eng</language><publisher>England: Bioscientifica Ltd</publisher><subject>Animals ; Antioxidants - metabolism ; Corpus Luteum - diagnostic imaging ; Corpus Luteum - metabolism ; Estrous Cycle - metabolism ; Female ; Melatonin - blood ; Melatonin - deficiency ; Models, Animal ; Ovarian Follicle - diagnostic imaging ; Ovarian Follicle - metabolism ; Pineal Gland - metabolism ; Pineal Gland - surgery ; Progesterone - blood ; Reproduction ; Seasons ; Sheep ; Time Factors ; Ultrasonography</subject><ispartof>Reproduction (Cambridge, England), 2014-06, Vol.147 (6), p.885-895</ispartof><rights>2014 Society for Reproduction and Fertility</rights><rights>2014 Society for Reproduction and Fertility.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b368t-2ca5614955b6c1d0137c65b9026f9cc64f5f95b2726b2fbab6624b083750b4cd3</citedby><cites>FETCH-LOGICAL-b368t-2ca5614955b6c1d0137c65b9026f9cc64f5f95b2726b2fbab6624b083750b4cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24570480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manca, Maria Elena</creatorcontrib><creatorcontrib>Manunta, Maria Lucia</creatorcontrib><creatorcontrib>Spezzigu, Antonio</creatorcontrib><creatorcontrib>Torres-Rovira, Laura</creatorcontrib><creatorcontrib>Gonzalez-Bulnes, Antonio</creatorcontrib><creatorcontrib>Pasciu, Valeria</creatorcontrib><creatorcontrib>Piu, Peter</creatorcontrib><creatorcontrib>Leoni, Giovanni G</creatorcontrib><creatorcontrib>Succu, Sara</creatorcontrib><creatorcontrib>Chesneau, Didier</creatorcontrib><creatorcontrib>Naitana, Salvatore</creatorcontrib><creatorcontrib>Berlinguer, Fiammetta</creatorcontrib><title>Melatonin deprival modifies follicular and corpus luteal growth dynamics in a sheep model</title><title>Reproduction (Cambridge, England)</title><addtitle>Reproduction</addtitle><description>This study assessed the effect of melatonin deprival on ovarian status and function in sheep. Experimental procedures were carried out within two consecutive breeding seasons. Animals were divided into two groups: pinealectomised (n=6) and sham-operated (n=6). The completeness of the pineal gland removal was confirmed by the plasma concentration of melatonin. Ovarian status was monitored by ovarian ultrasonography for 1 year to study reproductive seasonality. Follicular and corpus luteal growth dynamics were assessed during an induced oestrous cycle. As the effects of melatonin on the ovary may also be mediated by its antioxidant properties, plasma Trolox equivalent antioxidant capacity (TEAC) was determined monthly for 1 year. Pinealectomy significantly extended the breeding season (310±24.7 vs 217.5±24.7 days in controls; P<0.05). Both pinealectomised and sham-operated ewes showed a well-defined wave-like pattern of follicle dynamics; however, melatonin deficiency caused fewer waves during the oestrous cycle (4.3±0.2 vs 5.2±0.2; P<0.05), because waves were 1 day longer when compared with the controls (7.2±0.3 vs 6.1±0.3; P<0.05). The mean area of the corpora lutea (105.4±5.9 vs 65.4±5.9 mm2; P<0.05) and plasma progesterone levels (7.1±0.7 vs 4.9±0.6 ng/ml; P<0.05) were significantly higher in sham-operated ewes compared with pinealectomised ewes. In addition, TEAC values were significantly lower in pinealectomised ewes compared with control ones. These data suggest that melatonin, besides exerting its well-known role in the synchronisation of seasonal reproductive fluctuations, influences the growth pattern of the follicles and the steroidogenic capacity of the corpus luteum.Free Italian n Italian translation of this is freely available at http://www.reproduction-online.org/content/147/6/885/suppl/DC1.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Corpus Luteum - diagnostic imaging</subject><subject>Corpus Luteum - metabolism</subject><subject>Estrous Cycle - metabolism</subject><subject>Female</subject><subject>Melatonin - blood</subject><subject>Melatonin - deficiency</subject><subject>Models, Animal</subject><subject>Ovarian Follicle - diagnostic imaging</subject><subject>Ovarian Follicle - metabolism</subject><subject>Pineal Gland - metabolism</subject><subject>Pineal Gland - surgery</subject><subject>Progesterone - blood</subject><subject>Reproduction</subject><subject>Seasons</subject><subject>Sheep</subject><subject>Time Factors</subject><subject>Ultrasonography</subject><issn>1470-1626</issn><issn>1741-7899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LwzAYh4Mobk5P3iVHQar5TnuUMT9googePJUkTV0kbWrTKvvvzdj06Ol9Dw8P_B4ATjG6xJyiq-fFU4Zphhjie2CKJcOZzItiP_1MogwLIibgKMYPhDDPpTgEE8K4RCxHU_D2YL0aQutaWNmud1_KwyZUrnY2wjp478zoVQ9VW0ET-m6M0I-DTdR7H76HFazWrWqciTAZFIwra7uNwPpjcFArH-3J7s7A683iZX6XLR9v7-fXy0xTkQ8ZMYoLzArOtTC4QphKI7guEBF1YYxgNa8LrokkQpNaKy0EYRrlVHKkmanoDJxvvV0fPkcbh7Jx0VjvVWvDGEvMSU5pLqlM6MUWNX2Isbd1mRY3ql-XGJWblmVqWWJablom-mwnHnVjqz_2N14C8BbQLkTjbDukbEb9K_0B-_p_QA</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Manca, Maria Elena</creator><creator>Manunta, Maria Lucia</creator><creator>Spezzigu, Antonio</creator><creator>Torres-Rovira, Laura</creator><creator>Gonzalez-Bulnes, Antonio</creator><creator>Pasciu, Valeria</creator><creator>Piu, Peter</creator><creator>Leoni, Giovanni G</creator><creator>Succu, Sara</creator><creator>Chesneau, Didier</creator><creator>Naitana, Salvatore</creator><creator>Berlinguer, Fiammetta</creator><general>Bioscientifica Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201406</creationdate><title>Melatonin deprival modifies follicular and corpus luteal growth dynamics in a sheep model</title><author>Manca, Maria Elena ; Manunta, Maria Lucia ; Spezzigu, Antonio ; Torres-Rovira, Laura ; Gonzalez-Bulnes, Antonio ; Pasciu, Valeria ; Piu, Peter ; Leoni, Giovanni G ; Succu, Sara ; Chesneau, Didier ; Naitana, Salvatore ; Berlinguer, Fiammetta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b368t-2ca5614955b6c1d0137c65b9026f9cc64f5f95b2726b2fbab6624b083750b4cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Corpus Luteum - diagnostic imaging</topic><topic>Corpus Luteum - metabolism</topic><topic>Estrous Cycle - metabolism</topic><topic>Female</topic><topic>Melatonin - blood</topic><topic>Melatonin - deficiency</topic><topic>Models, Animal</topic><topic>Ovarian Follicle - diagnostic imaging</topic><topic>Ovarian Follicle - metabolism</topic><topic>Pineal Gland - metabolism</topic><topic>Pineal Gland - surgery</topic><topic>Progesterone - blood</topic><topic>Reproduction</topic><topic>Seasons</topic><topic>Sheep</topic><topic>Time Factors</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manca, Maria Elena</creatorcontrib><creatorcontrib>Manunta, Maria Lucia</creatorcontrib><creatorcontrib>Spezzigu, Antonio</creatorcontrib><creatorcontrib>Torres-Rovira, Laura</creatorcontrib><creatorcontrib>Gonzalez-Bulnes, Antonio</creatorcontrib><creatorcontrib>Pasciu, Valeria</creatorcontrib><creatorcontrib>Piu, Peter</creatorcontrib><creatorcontrib>Leoni, Giovanni G</creatorcontrib><creatorcontrib>Succu, Sara</creatorcontrib><creatorcontrib>Chesneau, Didier</creatorcontrib><creatorcontrib>Naitana, Salvatore</creatorcontrib><creatorcontrib>Berlinguer, Fiammetta</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manca, Maria Elena</au><au>Manunta, Maria Lucia</au><au>Spezzigu, Antonio</au><au>Torres-Rovira, Laura</au><au>Gonzalez-Bulnes, Antonio</au><au>Pasciu, Valeria</au><au>Piu, Peter</au><au>Leoni, Giovanni G</au><au>Succu, Sara</au><au>Chesneau, Didier</au><au>Naitana, Salvatore</au><au>Berlinguer, Fiammetta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melatonin deprival modifies follicular and corpus luteal growth dynamics in a sheep model</atitle><jtitle>Reproduction (Cambridge, England)</jtitle><addtitle>Reproduction</addtitle><date>2014-06</date><risdate>2014</risdate><volume>147</volume><issue>6</issue><spage>885</spage><epage>895</epage><pages>885-895</pages><issn>1470-1626</issn><eissn>1741-7899</eissn><abstract>This study assessed the effect of melatonin deprival on ovarian status and function in sheep. Experimental procedures were carried out within two consecutive breeding seasons. Animals were divided into two groups: pinealectomised (n=6) and sham-operated (n=6). The completeness of the pineal gland removal was confirmed by the plasma concentration of melatonin. Ovarian status was monitored by ovarian ultrasonography for 1 year to study reproductive seasonality. Follicular and corpus luteal growth dynamics were assessed during an induced oestrous cycle. As the effects of melatonin on the ovary may also be mediated by its antioxidant properties, plasma Trolox equivalent antioxidant capacity (TEAC) was determined monthly for 1 year. Pinealectomy significantly extended the breeding season (310±24.7 vs 217.5±24.7 days in controls; P<0.05). Both pinealectomised and sham-operated ewes showed a well-defined wave-like pattern of follicle dynamics; however, melatonin deficiency caused fewer waves during the oestrous cycle (4.3±0.2 vs 5.2±0.2; P<0.05), because waves were 1 day longer when compared with the controls (7.2±0.3 vs 6.1±0.3; P<0.05). The mean area of the corpora lutea (105.4±5.9 vs 65.4±5.9 mm2; P<0.05) and plasma progesterone levels (7.1±0.7 vs 4.9±0.6 ng/ml; P<0.05) were significantly higher in sham-operated ewes compared with pinealectomised ewes. In addition, TEAC values were significantly lower in pinealectomised ewes compared with control ones. These data suggest that melatonin, besides exerting its well-known role in the synchronisation of seasonal reproductive fluctuations, influences the growth pattern of the follicles and the steroidogenic capacity of the corpus luteum.Free Italian n Italian translation of this is freely available at http://www.reproduction-online.org/content/147/6/885/suppl/DC1.</abstract><cop>England</cop><pub>Bioscientifica Ltd</pub><pmid>24570480</pmid><doi>10.1530/REP-13-0405</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Reproduction (Cambridge, England), 2014-06, Vol.147 (6), p.885-895 |
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| subjects | Animals Antioxidants - metabolism Corpus Luteum - diagnostic imaging Corpus Luteum - metabolism Estrous Cycle - metabolism Female Melatonin - blood Melatonin - deficiency Models, Animal Ovarian Follicle - diagnostic imaging Ovarian Follicle - metabolism Pineal Gland - metabolism Pineal Gland - surgery Progesterone - blood Reproduction Seasons Sheep Time Factors Ultrasonography |
| title | Melatonin deprival modifies follicular and corpus luteal growth dynamics in a sheep model |
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