Effects of Hydrochlorothiazide on the Pharmacokinetics, Pharmacodynamics, and Tolerability of Canagliflozin, a Sodium Glucose Co-transporter 2 Inhibitor, in Healthy Participants

Abstract Background Many patients with type 2 diabetes mellitus (T2DM) also have hypertension, which is commonly treated with thiazide diuretics, including hydrochlorothiazide (HCTZ). Canagliflozin, a sodium glucose cotransporter 2 inhibitor developed for the treatment of T2DM, lowers plasma glucose...

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Veröffentlicht in:	Clinical therapeutics 2014-05, Vol.36 (5), p.698-710
Hauptverfasser:	Devineni, Damayanthi, PhD, Vaccaro, Nicole, BS, Polidori, David, PhD, Rusch, Sarah, MSc, Wajs, Ewa, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Blood - drug effects Blood diseases Canagliflozin Diabetes Diabetes. Impaired glucose tolerance diuretic Drug Administration Schedule Drug Therapy, Combination - adverse effects drug–drug interaction Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glucose Glucosides - administration & dosage Glucosides - adverse effects Glucosides - pharmacokinetics Healthy Volunteers Humans hydrochlorothiazide Hydrochlorothiazide - administration & dosage Hydrochlorothiazide - pharmacology Hypertension Internal Medicine Male Medical Education Medical sciences Middle Aged pharmacodynamics pharmacokinetics Pharmacology. Drug treatments Potassium Sodium sodium glucose co-transporter 2 (SGLT2) inhibitor Sodium-Glucose Transporter 2 - antagonists & inhibitors Thiophenes - administration & dosage Thiophenes - adverse effects Thiophenes - pharmacokinetics type 2 diabetes mellitus Urine Urine - physiology Young Adult
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