Progress on pursuit of human cytomegalovirus vaccines for prevention of congenital infection and disease

Highlight • An effective vaccine for prevention of congenital HCMV infection is of high medical significance. • Previous candidates of modified virus vaccines or individual antigen vaccines were of moderate efficacy. • A pentameric gH complex is missing in vaccine composition in all previous candida...

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Veröffentlicht in:	Vaccine 2014-05, Vol.32 (22), p.2525-2533
Hauptverfasser:	Fu, Tong-Ming, An, Zhiqiang, Wang, Dai
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Applied microbiology Biological and medical sciences Congenital infection and disease Cytomegalovirus Infections - prevention & control Cytomegalovirus Vaccines - therapeutic use Disease Transmission, Infectious - prevention & control Female Fundamental and applied biological sciences. Psychology Hearing loss Human cytomegalovirus Humans Immunity, Innate Infectious Disease Transmission, Vertical - prevention & control Medical research Microbiology Miscellaneous Neutralizing antibodies Pregnancy Pregnancy Complications, Infectious - therapy Studies T-cells Transplants & implants Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - therapeutic use Vaccines, Synthetic - therapeutic use Virology Womens health
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