Mesothelioma and asbestos fiber type. Evidence from lung tissue analyses
Lung tissue samples from 78 cases from autopsy of mesothelioma in Canada, 1980 through 1984, and from matched referents were examined by optical and analytical transmission electron microscopic study. Concentrations of amosite, crocidolite, and tremolite fibers, and of typical asbestos bodies discri...
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| Veröffentlicht in: | Cancer 1989-04, Vol.63 (8), p.1544-1547 |
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| container_title | Cancer |
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| creator | McDonald, J. C. Armstrong, B. Case, B. Doell, D. McCaughey, W. T. E. McDonald, A. D. Sébastien, P. |
| description | Lung tissue samples from 78 cases from autopsy of mesothelioma in Canada, 1980 through 1984, and from matched referents were examined by optical and analytical transmission electron microscopic study. Concentrations of amosite, crocidolite, and tremolite fibers, and of typical asbestos bodies discriminated sharply between cases and referents. The distributions of chrysotile and anthophyllite/talc fibers and of all other natural and man‐made inorganic fibers (≥8 μm) in the two series were quite similar. Relative risk was related to the concentration of long (≥8 μm) amphibole fibers with no additional information provided by shorter fibers. The proportion of long fibers was much higher for amphiboles than chrysotile and, except for chrysotile, systematically higher in cases than referents. Amphibole asbestos fibers could explain most mesothelioma cases in Canada and other inorganic fibers, including chrysotile, very few. Fibrous tremolite, contaminant of many industrial minerals including chrysotile, probably explained most cases in the Quebec mining region and perhaps 20% elsewhere. |
| doi_str_mv | 10.1002/1097-0142(19890415)63:8<1544::AID-CNCR2820630815>3.0.CO;2-G |
| format | Article |
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Evidence from lung tissue analyses</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>McDonald, J. C. ; Armstrong, B. ; Case, B. ; Doell, D. ; McCaughey, W. T. E. ; McDonald, A. D. ; Sébastien, P.</creator><creatorcontrib>McDonald, J. C. ; Armstrong, B. ; Case, B. ; Doell, D. ; McCaughey, W. T. E. ; McDonald, A. D. ; Sébastien, P.</creatorcontrib><description>Lung tissue samples from 78 cases from autopsy of mesothelioma in Canada, 1980 through 1984, and from matched referents were examined by optical and analytical transmission electron microscopic study. Concentrations of amosite, crocidolite, and tremolite fibers, and of typical asbestos bodies discriminated sharply between cases and referents. The distributions of chrysotile and anthophyllite/talc fibers and of all other natural and man‐made inorganic fibers (≥8 μm) in the two series were quite similar. Relative risk was related to the concentration of long (≥8 μm) amphibole fibers with no additional information provided by shorter fibers. The proportion of long fibers was much higher for amphiboles than chrysotile and, except for chrysotile, systematically higher in cases than referents. Amphibole asbestos fibers could explain most mesothelioma cases in Canada and other inorganic fibers, including chrysotile, very few. Fibrous tremolite, contaminant of many industrial minerals including chrysotile, probably explained most cases in the Quebec mining region and perhaps 20% elsewhere.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19890415)63:8<1544::AID-CNCR2820630815>3.0.CO;2-G</identifier><identifier>PMID: 2924262</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Asbestos - adverse effects ; Asbestos - analysis ; Biological and medical sciences ; Canada ; Female ; Humans ; Lung Neoplasms - epidemiology ; Lung Neoplasms - etiology ; Lung Neoplasms - pathology ; Male ; Medical sciences ; Mesothelioma - epidemiology ; Mesothelioma - etiology ; Mesothelioma - pathology ; Pneumology ; Sex Factors ; Tumors of the respiratory system and mediastinum</subject><ispartof>Cancer, 1989-04, Vol.63 (8), p.1544-1547</ispartof><rights>Copyright © 1989 American Cancer Society</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5295-364b0b9033dfbaff4f5e3490872fb03cbc9ab7344613e173921bbfa873f03fc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7171037$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2924262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McDonald, J. C.</creatorcontrib><creatorcontrib>Armstrong, B.</creatorcontrib><creatorcontrib>Case, B.</creatorcontrib><creatorcontrib>Doell, D.</creatorcontrib><creatorcontrib>McCaughey, W. T. E.</creatorcontrib><creatorcontrib>McDonald, A. D.</creatorcontrib><creatorcontrib>Sébastien, P.</creatorcontrib><title>Mesothelioma and asbestos fiber type. Evidence from lung tissue analyses</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Lung tissue samples from 78 cases from autopsy of mesothelioma in Canada, 1980 through 1984, and from matched referents were examined by optical and analytical transmission electron microscopic study. Concentrations of amosite, crocidolite, and tremolite fibers, and of typical asbestos bodies discriminated sharply between cases and referents. The distributions of chrysotile and anthophyllite/talc fibers and of all other natural and man‐made inorganic fibers (≥8 μm) in the two series were quite similar. Relative risk was related to the concentration of long (≥8 μm) amphibole fibers with no additional information provided by shorter fibers. The proportion of long fibers was much higher for amphiboles than chrysotile and, except for chrysotile, systematically higher in cases than referents. Amphibole asbestos fibers could explain most mesothelioma cases in Canada and other inorganic fibers, including chrysotile, very few. Fibrous tremolite, contaminant of many industrial minerals including chrysotile, probably explained most cases in the Quebec mining region and perhaps 20% elsewhere.</description><subject>Asbestos - adverse effects</subject><subject>Asbestos - analysis</subject><subject>Biological and medical sciences</subject><subject>Canada</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesothelioma - epidemiology</subject><subject>Mesothelioma - etiology</subject><subject>Mesothelioma - pathology</subject><subject>Pneumology</subject><subject>Sex Factors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF2LEzEUhoMoa139CcJciOjF1JOcZDLpirCMa3dhtSAKgheHZJroyHzUSUfpvzeltaAXgleHw_vBy8NYxWHOAcQLDkbnwKV4xk1pQHL1vMBF-ZIrKReLy5vXefWuei9KAQVCydUrnMO8Wl2IfHmHzU7pu2wGAGWuJH66zx7E-C29Wig8Y2fCCCkKMWPXb30ctl992wydzWy_zmx0Pm6HmIXG-THb7jZ-nl39aNa-r30WxqHL2qn_km2bGCefIrbdRR8fsnvBttE_Ot5z9vHN1YfqOr9dLW-qy9u8VsKoHAvpwBlAXAdnQ5BBeZQGSi2CA6xdbazTKGXB0XONRnDngi01BsBQczxnTw-9m3H4PqWl1DWx9m1rez9MkbgSGlMsGT8fjPU4xDj6QJux6ey4Iw6050x7UrQnRb85U4FU0p4zUeJMf3ImJKBqRYKWqf3xccbkOr8-dR_BJv3JUbextm0YbV838WTTXHNAnWzhYPvZtH73fwv_OfAvBX8BCEmnFQ</recordid><startdate>19890415</startdate><enddate>19890415</enddate><creator>McDonald, J. C.</creator><creator>Armstrong, B.</creator><creator>Case, B.</creator><creator>Doell, D.</creator><creator>McCaughey, W. T. E.</creator><creator>McDonald, A. D.</creator><creator>Sébastien, P.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19890415</creationdate><title>Mesothelioma and asbestos fiber type. Evidence from lung tissue analyses</title><author>McDonald, J. C. ; Armstrong, B. ; Case, B. ; Doell, D. ; McCaughey, W. T. E. ; McDonald, A. D. ; Sébastien, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5295-364b0b9033dfbaff4f5e3490872fb03cbc9ab7344613e173921bbfa873f03fc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Asbestos - adverse effects</topic><topic>Asbestos - analysis</topic><topic>Biological and medical sciences</topic><topic>Canada</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - etiology</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesothelioma - epidemiology</topic><topic>Mesothelioma - etiology</topic><topic>Mesothelioma - pathology</topic><topic>Pneumology</topic><topic>Sex Factors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McDonald, J. C.</creatorcontrib><creatorcontrib>Armstrong, B.</creatorcontrib><creatorcontrib>Case, B.</creatorcontrib><creatorcontrib>Doell, D.</creatorcontrib><creatorcontrib>McCaughey, W. T. E.</creatorcontrib><creatorcontrib>McDonald, A. D.</creatorcontrib><creatorcontrib>Sébastien, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McDonald, J. C.</au><au>Armstrong, B.</au><au>Case, B.</au><au>Doell, D.</au><au>McCaughey, W. T. E.</au><au>McDonald, A. D.</au><au>Sébastien, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mesothelioma and asbestos fiber type. Evidence from lung tissue analyses</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1989-04-15</date><risdate>1989</risdate><volume>63</volume><issue>8</issue><spage>1544</spage><epage>1547</epage><pages>1544-1547</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Lung tissue samples from 78 cases from autopsy of mesothelioma in Canada, 1980 through 1984, and from matched referents were examined by optical and analytical transmission electron microscopic study. Concentrations of amosite, crocidolite, and tremolite fibers, and of typical asbestos bodies discriminated sharply between cases and referents. The distributions of chrysotile and anthophyllite/talc fibers and of all other natural and man‐made inorganic fibers (≥8 μm) in the two series were quite similar. Relative risk was related to the concentration of long (≥8 μm) amphibole fibers with no additional information provided by shorter fibers. The proportion of long fibers was much higher for amphiboles than chrysotile and, except for chrysotile, systematically higher in cases than referents. Amphibole asbestos fibers could explain most mesothelioma cases in Canada and other inorganic fibers, including chrysotile, very few. Fibrous tremolite, contaminant of many industrial minerals including chrysotile, probably explained most cases in the Quebec mining region and perhaps 20% elsewhere.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2924262</pmid><doi>10.1002/1097-0142(19890415)63:8<1544::AID-CNCR2820630815>3.0.CO;2-G</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Asbestos - adverse effects Asbestos - analysis Biological and medical sciences Canada Female Humans Lung Neoplasms - epidemiology Lung Neoplasms - etiology Lung Neoplasms - pathology Male Medical sciences Mesothelioma - epidemiology Mesothelioma - etiology Mesothelioma - pathology Pneumology Sex Factors Tumors of the respiratory system and mediastinum |
| title | Mesothelioma and asbestos fiber type. Evidence from lung tissue analyses |
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