Distribution of catalase and its modulation by 12-O-tetradecanoylphorbol-13-acetate in murine dermis and subpopulations of keratinocytes differing in their stages of differentiation

Topical treatment of female SENCAR mice with 12-O-tetradecanoylphorbol- 13-acetate (TPA) reduced both dermal and epidermal catalase-specific activities 38% and 51% within 6 h and 18 h of promoter application, respectively. Dermal catalase activity recovered to control levels within 72 h of treatment...

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Veröffentlicht in:	Carcinogenesis (New York) 1988-07, Vol.9 (7), p.1259-1264
Hauptverfasser:	Reiner, John J., Hale, Michael A., Cantu, Amador R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Catalase - metabolism Cell Differentiation Cell Separation Chemical agents Enzyme Activation - drug effects Epidermis - enzymology Ethanol - pharmacology Medical sciences Mice Skin - cytology Skin - drug effects Skin - enzymology Tetradecanoylphorbol Acetate - pharmacology Tumors
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