Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A

Muscle-specific RING finger protein-1 (MuRF1) is an E3 ligase that inhibits cardiac hypertrophy. However, how MuRF1 regulates cardiac hypertrophy and function during pressure overload (PO) remains poorly understood. We investigated the role of endogenous MuRF1 in regulating cardiac hypertrophy in re...

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Veröffentlicht in:	Circulation. Heart failure 2014-05, Vol.7 (3), p.479-490
Hauptverfasser:	Maejima, Yasuhiro, Usui, Soichiro, Zhai, Peiyong, Takamura, Masayuki, Kaneko, Shuichi, Zablocki, Daniela, Yokota, Mitsuhiro, Isobe, Mitsuaki, Sadoshima, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - physiopathology Calcineurin - metabolism Cardiomegaly - metabolism Cardiomegaly - pathology Disease Models, Animal Down-Regulation - physiology Mice Mice, Knockout Mice, Transgenic Muscle Proteins - deficiency Muscle Proteins - genetics Muscle Proteins - metabolism Myocardium - metabolism Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology NFATC Transcription Factors - metabolism Signal Transduction - physiology Tripartite Motif Proteins Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
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