Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor

Thyroid hormone (TH) is essential for vertebrate development and the homeostasis of most adult tissues, including bone. TH stimulates target gene expression through the nuclear thyroid receptors TRα and TRβ; however, TH also has rapid, transcription-independent (nongenomic) effects. We found a previ...

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Veröffentlicht in:	Science signaling 2014-05, Vol.7 (326), p.ra48-ra48
Hauptverfasser:	Kalyanaraman, Hema, Schwappacher, Raphaela, Joshua, Jisha, Zhuang, Shunhui, Scott, Brian T, Klos, Matthew, Casteel, Darren E, Frangos, John A, Dillmann, Wolfgang, Boss, Gerry R, Pilz, Renate B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Cells, Cultured Humans Hypothyroidism - genetics Hypothyroidism - metabolism MAP Kinase Signaling System Membrane Microdomains - genetics Membrane Microdomains - metabolism Mice Mice, Transgenic Osteocytes - metabolism Osteogenesis - genetics Rats Receptors, Thyroid Hormone - genetics Receptors, Thyroid Hormone - metabolism Thyroid Hormones - genetics Thyroid Hormones - metabolism
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