Nucleic Acid–Metal Organic Framework (MOF) Nanoparticle Conjugates

Nanoparticles of a metal–organic framework (MOF), UiO-66-N3 (Zr6O4OH4(C8H3O4–N3)6), were synthesized. The surface of the MOF was covalently functionalized with oligonucleotides, utilizing a strain promoted click reaction between DNA appended with dibenzylcyclooctyne and azide-functionalized UiO-66...

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Veröffentlicht in:	Journal of the American Chemical Society 2014-05, Vol.136 (20), p.7261-7264
Hauptverfasser:	Morris, William, Briley, William E, Auyeung, Evelyn, Cabezas, Maria D, Mirkin, Chad A
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry HeLa Cells Humans Metal Nanoparticles - chemistry Models, Molecular Molecular Structure Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Particle Size Surface Properties Zirconium - chemistry
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container_title	Journal of the American Chemical Society
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creator	Morris, William Briley, William E Auyeung, Evelyn Cabezas, Maria D Mirkin, Chad A
description	Nanoparticles of a metal–organic framework (MOF), UiO-66-N3 (Zr6O4OH4(C8H3O4–N3)6), were synthesized. The surface of the MOF was covalently functionalized with oligonucleotides, utilizing a strain promoted click reaction between DNA appended with dibenzylcyclooctyne and azide-functionalized UiO-66-N3 to create the first MOF nanoparticle–nucleic acid conjugates. The structure of the framework was preserved throughout the chemical transformation, and the surface coverage of DNA was quantified. Due to the small pore sizes, the particles are only modified on their surfaces. When dispersed in aqueous NaCl, they exhibit increased stability and enhanced cellular uptake when compared with unfunctionalized MOF particles of comparable size.
doi_str_mv	10.1021/ja503215w
format	Article
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Am. Chem. Soc</addtitle><date>2014-05-21</date><risdate>2014</risdate><volume>136</volume><issue>20</issue><spage>7261</spage><epage>7264</epage><pages>7261-7264</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><abstract>Nanoparticles of a metal–organic framework (MOF), UiO-66-N3 (Zr6O4OH4(C8H3O4–N3)6), were synthesized. The surface of the MOF was covalently functionalized with oligonucleotides, utilizing a strain promoted click reaction between DNA appended with dibenzylcyclooctyne and azide-functionalized UiO-66-N3 to create the first MOF nanoparticle–nucleic acid conjugates. The structure of the framework was preserved throughout the chemical transformation, and the surface coverage of DNA was quantified. Due to the small pore sizes, the particles are only modified on their surfaces. 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subjects	DNA - chemistry HeLa Cells Humans Metal Nanoparticles - chemistry Models, Molecular Molecular Structure Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Particle Size Surface Properties Zirconium - chemistry
title	Nucleic Acid–Metal Organic Framework (MOF) Nanoparticle Conjugates
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