Dependence of RBE on fraction size for negative pi-meson induced renal injury
A method is described for quantitation of murine late renal radiation response using histopathologic grading. Effective dose-50 percent (ED 50) is defined as the radiation dose at which 50% of animals showed renal tubular alterations of a specific histologic grade. The designated histologic grade wa...
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| Veröffentlicht in: | Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1981-02, Vol.7 (2), p.223-227 |
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| container_title | Int. J. Radiat. Oncol., Biol. Phys.; (United States) |
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| creator | Jordan, Scott W. Yuhas, John M. Butler, Jeanne L.B. Kligerman, Morton M. |
| description | A method is described for quantitation of murine late renal radiation response using histopathologic grading. Effective dose-50 percent (ED
50) is defined as the radiation dose at which 50% of animals showed renal tubular alterations of a specific histologic grade. The designated histologic grade was selected on the basis of its correlation with renal failure manifested by elevated blood urea nitrogen levels, weight loss and mortality of the experimental animals. Using this system, the ED
50 was determined for single, two, five, and fifteen (daily) fraction exposures with 300 kVp X rays and negative pi-meson (pion) beams generated at the Los Alamos Meson Physics Facility. The correlation between total radiation dose and the number of fractions was linear for both x ray and pion exposures when plotted on logarith
mic coordinates, i.e. this relationship followed a power function. The relative biological effectiveness (RBE) for pions increased from 1.12 for a single dose of 1130 red, to 2.18 for 15 daily fractions of 145 rad. This latter fraction size approaches that being used in clinical trials, and provides an estimate of the RBE to be expected for kidney injury under conventional treatment protocols. |
| doi_str_mv | 10.1016/0360-3016(81)90441-7 |
| format | Article |
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50) is defined as the radiation dose at which 50% of animals showed renal tubular alterations of a specific histologic grade. The designated histologic grade was selected on the basis of its correlation with renal failure manifested by elevated blood urea nitrogen levels, weight loss and mortality of the experimental animals. Using this system, the ED
50 was determined for single, two, five, and fifteen (daily) fraction exposures with 300 kVp X rays and negative pi-meson (pion) beams generated at the Los Alamos Meson Physics Facility. The correlation between total radiation dose and the number of fractions was linear for both x ray and pion exposures when plotted on logarith
mic coordinates, i.e. this relationship followed a power function. The relative biological effectiveness (RBE) for pions increased from 1.12 for a single dose of 1130 red, to 2.18 for 15 daily fractions of 145 rad. This latter fraction size approaches that being used in clinical trials, and provides an estimate of the RBE to be expected for kidney injury under conventional treatment protocols.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/0360-3016(81)90441-7</identifier><identifier>PMID: 7216859</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>AMIDES ; ANIMALS ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BLOOD CHEMISTRY ; BODY ; BOSONS ; CARBONIC ACID DERIVATIVES ; DATA ; Dose-Response Relationship, Radiation ; DOSE-RESPONSE RELATIONSHIPS ; DOSES ; ELECTROMAGNETIC RADIATION ; ELEMENTARY PARTICLES ; EXPERIMENTAL DATA ; FRACTIONATED IRRADIATION ; Fractionated radiation exposure ; HADRONS ; INFORMATION ; INJURIES ; IONIZING RADIATIONS ; IRRADIATION ; Kidney - radiation effects ; KIDNEYS ; MAMMALS ; MESONS ; MICE ; Negative pi-mesons ; NUMERICAL DATA ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANS ; PATHOLOGICAL CHANGES ; Pion RBE ; PIONS ; PIONS MINUS ; PSEUDOSCALAR MESONS ; Radiation Dosage ; RADIATION DOSES ; RADIATION EFFECTS ; RADIATION INJURIES ; Radiation Injuries, Experimental ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIATIONS ; RBE ; RBE versus fraction size ; Relative Biological Effectiveness ; Renal radiation injury ; RODENTS ; UREA ; VERTEBRATES 560152 -- Radiation Effects on Animals-- Animals ; X RADIATION ; X rays</subject><ispartof>Int. J. Radiat. Oncol., Biol. Phys.; (United States), 1981-02, Vol.7 (2), p.223-227</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-e15dc0c661060d7f69c47b7d3bdc6e8054e12abda292a522232548699c99f5f13</citedby><cites>FETCH-LOGICAL-c415t-e15dc0c661060d7f69c47b7d3bdc6e8054e12abda292a522232548699c99f5f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0360-3016(81)90441-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7216859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6619592$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Jordan, Scott W.</creatorcontrib><creatorcontrib>Yuhas, John M.</creatorcontrib><creatorcontrib>Butler, Jeanne L.B.</creatorcontrib><creatorcontrib>Kligerman, Morton M.</creatorcontrib><creatorcontrib>Univ. of New Mexico, Albuquerque</creatorcontrib><title>Dependence of RBE on fraction size for negative pi-meson induced renal injury</title><title>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>A method is described for quantitation of murine late renal radiation response using histopathologic grading. Effective dose-50 percent (ED
50) is defined as the radiation dose at which 50% of animals showed renal tubular alterations of a specific histologic grade. The designated histologic grade was selected on the basis of its correlation with renal failure manifested by elevated blood urea nitrogen levels, weight loss and mortality of the experimental animals. Using this system, the ED
50 was determined for single, two, five, and fifteen (daily) fraction exposures with 300 kVp X rays and negative pi-meson (pion) beams generated at the Los Alamos Meson Physics Facility. The correlation between total radiation dose and the number of fractions was linear for both x ray and pion exposures when plotted on logarith
mic coordinates, i.e. this relationship followed a power function. The relative biological effectiveness (RBE) for pions increased from 1.12 for a single dose of 1130 red, to 2.18 for 15 daily fractions of 145 rad. This latter fraction size approaches that being used in clinical trials, and provides an estimate of the RBE to be expected for kidney injury under conventional treatment protocols.</description><subject>AMIDES</subject><subject>ANIMALS</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BLOOD CHEMISTRY</subject><subject>BODY</subject><subject>BOSONS</subject><subject>CARBONIC ACID DERIVATIVES</subject><subject>DATA</subject><subject>Dose-Response Relationship, Radiation</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>DOSES</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>ELEMENTARY PARTICLES</subject><subject>EXPERIMENTAL DATA</subject><subject>FRACTIONATED IRRADIATION</subject><subject>Fractionated radiation exposure</subject><subject>HADRONS</subject><subject>INFORMATION</subject><subject>INJURIES</subject><subject>IONIZING RADIATIONS</subject><subject>IRRADIATION</subject><subject>Kidney - radiation effects</subject><subject>KIDNEYS</subject><subject>MAMMALS</subject><subject>MESONS</subject><subject>MICE</subject><subject>Negative pi-mesons</subject><subject>NUMERICAL DATA</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>PATHOLOGICAL CHANGES</subject><subject>Pion RBE</subject><subject>PIONS</subject><subject>PIONS MINUS</subject><subject>PSEUDOSCALAR MESONS</subject><subject>Radiation Dosage</subject><subject>RADIATION DOSES</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION INJURIES</subject><subject>Radiation Injuries, Experimental</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>RBE</subject><subject>RBE versus fraction size</subject><subject>Relative Biological Effectiveness</subject><subject>Renal radiation injury</subject><subject>RODENTS</subject><subject>UREA</subject><subject>VERTEBRATES 560152 -- Radiation Effects on Animals-- Animals</subject><subject>X RADIATION</subject><subject>X rays</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN9LHDEQx0NR7Gn7HygsfRB9WJvJbpLNi6DnT7AUSgt9C7lkto3cJWeyK9i_vlnv8NGnmeH7ne8MH0IOgZ4BBfGVNoLWTelOOjhVtG2hlh_IDDqp6obz3ztk9mb5SPZzfqSUAsh2j-xJBqLjaka-XeEag8NgsYp99ePyuoqh6pOxgy9N9v-w6mOqAv4xg3_Gau3rFeYi-eBGi65KGMyyTI9jevlEdnuzzPh5Ww_Ir5vrn_O7-uH77f384qG2LfChRuDOUisEUEGd7IWyrVxI1yycFdhR3iIws3CGKWY4Y6xhvO2EUlapnvfQHJAvm9yYB6-z9QPavzaGgHbQJVZxxYrpeGNap_g0Yh70ymeLy6UJGMesgTPJGtkVY7sx2hRzTtjrdfIrk140UD2h1hNHPXHUHehX1FqWtaNt_rhYoXtb2rIt-vlGx0Li2WOaHp1AO5-mP1307x_4D_pXi6w</recordid><startdate>198102</startdate><enddate>198102</enddate><creator>Jordan, Scott W.</creator><creator>Yuhas, John M.</creator><creator>Butler, Jeanne L.B.</creator><creator>Kligerman, Morton M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>OTOTI</scope></search><sort><creationdate>198102</creationdate><title>Dependence of RBE on fraction size for negative pi-meson induced renal injury</title><author>Jordan, Scott W. ; Yuhas, John M. ; Butler, Jeanne L.B. ; Kligerman, Morton M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-e15dc0c661060d7f69c47b7d3bdc6e8054e12abda292a522232548699c99f5f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>AMIDES</topic><topic>ANIMALS</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BLOOD CHEMISTRY</topic><topic>BODY</topic><topic>BOSONS</topic><topic>CARBONIC ACID DERIVATIVES</topic><topic>DATA</topic><topic>Dose-Response Relationship, Radiation</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>DOSES</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>ELEMENTARY PARTICLES</topic><topic>EXPERIMENTAL DATA</topic><topic>FRACTIONATED IRRADIATION</topic><topic>Fractionated radiation exposure</topic><topic>HADRONS</topic><topic>INFORMATION</topic><topic>INJURIES</topic><topic>IONIZING RADIATIONS</topic><topic>IRRADIATION</topic><topic>Kidney - radiation effects</topic><topic>KIDNEYS</topic><topic>MAMMALS</topic><topic>MESONS</topic><topic>MICE</topic><topic>Negative pi-mesons</topic><topic>NUMERICAL DATA</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>PATHOLOGICAL CHANGES</topic><topic>Pion RBE</topic><topic>PIONS</topic><topic>PIONS MINUS</topic><topic>PSEUDOSCALAR MESONS</topic><topic>Radiation Dosage</topic><topic>RADIATION DOSES</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION INJURIES</topic><topic>Radiation Injuries, Experimental</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIATIONS</topic><topic>RBE</topic><topic>RBE versus fraction size</topic><topic>Relative Biological Effectiveness</topic><topic>Renal radiation injury</topic><topic>RODENTS</topic><topic>UREA</topic><topic>VERTEBRATES 560152 -- Radiation Effects on Animals-- Animals</topic><topic>X RADIATION</topic><topic>X rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jordan, Scott W.</creatorcontrib><creatorcontrib>Yuhas, John M.</creatorcontrib><creatorcontrib>Butler, Jeanne L.B.</creatorcontrib><creatorcontrib>Kligerman, Morton M.</creatorcontrib><creatorcontrib>Univ. of New Mexico, Albuquerque</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><jtitle>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jordan, Scott W.</au><au>Yuhas, John M.</au><au>Butler, Jeanne L.B.</au><au>Kligerman, Morton M.</au><aucorp>Univ. of New Mexico, Albuquerque</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dependence of RBE on fraction size for negative pi-meson induced renal injury</atitle><jtitle>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1981-02</date><risdate>1981</risdate><volume>7</volume><issue>2</issue><spage>223</spage><epage>227</epage><pages>223-227</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>A method is described for quantitation of murine late renal radiation response using histopathologic grading. Effective dose-50 percent (ED
50) is defined as the radiation dose at which 50% of animals showed renal tubular alterations of a specific histologic grade. The designated histologic grade was selected on the basis of its correlation with renal failure manifested by elevated blood urea nitrogen levels, weight loss and mortality of the experimental animals. Using this system, the ED
50 was determined for single, two, five, and fifteen (daily) fraction exposures with 300 kVp X rays and negative pi-meson (pion) beams generated at the Los Alamos Meson Physics Facility. The correlation between total radiation dose and the number of fractions was linear for both x ray and pion exposures when plotted on logarith
mic coordinates, i.e. this relationship followed a power function. The relative biological effectiveness (RBE) for pions increased from 1.12 for a single dose of 1130 red, to 2.18 for 15 daily fractions of 145 rad. This latter fraction size approaches that being used in clinical trials, and provides an estimate of the RBE to be expected for kidney injury under conventional treatment protocols.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7216859</pmid><doi>10.1016/0360-3016(81)90441-7</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3016 |
| ispartof | Int. J. Radiat. Oncol., Biol. Phys.; (United States), 1981-02, Vol.7 (2), p.223-227 |
| issn | 0360-3016 1879-355X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | AMIDES ANIMALS BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BLOOD CHEMISTRY BODY BOSONS CARBONIC ACID DERIVATIVES DATA Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS DOSES ELECTROMAGNETIC RADIATION ELEMENTARY PARTICLES EXPERIMENTAL DATA FRACTIONATED IRRADIATION Fractionated radiation exposure HADRONS INFORMATION INJURIES IONIZING RADIATIONS IRRADIATION Kidney - radiation effects KIDNEYS MAMMALS MESONS MICE Negative pi-mesons NUMERICAL DATA ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS PATHOLOGICAL CHANGES Pion RBE PIONS PIONS MINUS PSEUDOSCALAR MESONS Radiation Dosage RADIATION DOSES RADIATION EFFECTS RADIATION INJURIES Radiation Injuries, Experimental RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RBE RBE versus fraction size Relative Biological Effectiveness Renal radiation injury RODENTS UREA VERTEBRATES 560152 -- Radiation Effects on Animals-- Animals X RADIATION X rays |
| title | Dependence of RBE on fraction size for negative pi-meson induced renal injury |
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